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DLG1: Structure, Function & Clinical significance

Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the SAP97 gene.

Language: English [EN]
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DLG1 topic overview

The analysis highlights Structure, Function and Clinical significance as prominent areas in the source structure around DLG1.

Related topics
23
Source areas
4
Connected nodes
27
Extracted relationships
179
Concept neighborhoods
14
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics
Structure · 7 topics
Function · 6 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DLG1, DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, B130052P05Rik, E-dlg/SAP97, mKIAA4187, discs large homolog 1, scribble cell polarity complex component, discs large MAGUK scaffo…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PDR, 2M3M, 2OQS, 2X7Z, 3RL7, 3RL8, 3W9Y, 4AMH, 4G69
Band
3q29 · 16 B2|16 22.4 cM
Bgee
endothelial cell · corpus callosum · dorsal motor nucleus of vagus nerve · inferior olivary nucleus · inferior ganglion of vagus nerve
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Structure

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DLG1 connects Entity context

The extracted context around DLG1 shows recurring relationship patterns in the source. For example, DLG1 → actin filament organization, activation of protein kinase activity, amyloid precursor protein metabolic process, apical plasma membrane, astral microtubule organization, basement membrane, basolateral plasma membrane, bicellular tight junction, bicellular tight junction assembly, branching involved in ureteric bud morphogenesis, cadherin binding, cell junction, cell projection membrane, cell-cell adhesion, cell-cell junction, chemical synaptic transmission, cortical actin cytoskeleton organization, cortical microtubule organization, cytoplasm, cytoplasmic side of plasma membrane Another extracted example is DLG1 → Brodmann area 23, condyle, conjunctival fornix, corpus callosum, dorsal motor nucleus of vagus nerve, endothelial cell, epithelium of colon, external globus pallidus, globus pallidus, hair follicle, inferior ganglion of vagus nerve, inferior olivary nucleus, medullary collecting duct, olfactory tubercle, Paneth cell, primary motor cortex, subthalamic nucleus, tail of embryo, utricle, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

DLG1

Top relations

Gene ontology · 114
DLG1 → actin filament organization, activation of protein kinase activity, amyloid precursor protein metabolic process, apical plasma membrane, astral microtubule organization, basement membrane, basolateral plasma membrane, bicellular tight junction, bicellular tight junction assembly, branching involved in ureteric bud morphogenesis, cadherin binding, cell junction, cell projection membrane, cell-cell adhesion, cell-cell junction, chemical synaptic transmission, cortical actin cytoskeleton organization, cortical microtubule organization, cytoplasm, cytoplasmic side of plasma membrane
Bgee · 20
DLG1 → Brodmann area 23, condyle, conjunctival fornix, corpus callosum, dorsal motor nucleus of vagus nerve, endothelial cell, epithelium of colon, external globus pallidus, globus pallidus, hair follicle, inferior ganglion of vagus nerve, inferior olivary nucleus, medullary collecting duct, olfactory tubercle, Paneth cell, primary motor cortex, subthalamic nucleus, tail of embryo, utricle, vestibular membrane of cochlear duct
RNA expression pattern · 20
DLG1 → Brodmann area 23, condyle, conjunctival fornix, corpus callosum, dorsal motor nucleus of vagus nerve, endothelial cell, epithelium of colon, external globus pallidus, globus pallidus, hair follicle, inferior ganglion of vagus nerve, inferior olivary nucleus, medullary collecting duct, olfactory tubercle, Paneth cell, primary motor cortex, subthalamic nucleus, tail of embryo, utricle, vestibular membrane of cochlear duct
Band · 2
DLG1 → 16 B2|16 22.4 cM, 3q29
Chr. · 2
DLG1 → Chromosome 16 (mouse), Chromosome 3 (human)
End · 2
DLG1 → 197,299,330 bp, 31,693,947 bp
related to Clinical significance · 2
DLG1 → Crohn's, Mutations
Aliases · 1
DLG1 → DLG1, DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, B130052P05Rik, E-dlg/SAP97, mKIAA4187, discs large homolog 1, scribble cell polarity complex component, discs large MAGUK scaffo…
Available structures · 1
DLG1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PDR, 2M3M, 2OQS, 2X7Z, 3RL7, 3RL8, 3W9Y, 4AMH, 4G69
BioGPS · 1
DLG1 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

sap97 gene human protein bp domain chr band function involved sap97's chromosome synaptic epithelial membrane external discs large expressed plasma

DLG1 relationships Subject–Predicate–Object triples

TTTA extracted 179 structured relationships around DLG1. Examples in this analysis include DLG1 → Aliases → DLG1, DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, B130052P05Rik, E-dlg/SAP97, mKIAA4187, discs large homolog 1, scribble cell polarity complex component, discs large MAGUK scaffo… and DLG1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PDR, 2M3M, 2OQS, 2X7Z, 3RL7, 3RL8, 3W9Y, 4AMH, 4G69. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DLG1AliasesDLG1, DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, B130052P05Rik, E-dlg/SAP97, mKIAA4187, discs large homolog 1, scribble cell polarity complex component, discs large MAGUK scaffo…1.00infobox
DLG1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PDR, 2M3M, 2OQS, 2X7Z, 3RL7, 3RL8, 3W9Y, 4AMH, 4G691.00infobox
DLG1Band3q291.00infobox
DLG1Band16 B2|16 22.4 cM1.00infobox
DLG1Bgeeendothelial cell1.00infobox
DLG1Bgeecorpus callosum1.00infobox
DLG1Bgeedorsal motor nucleus of vagus nerve1.00infobox
DLG1Bgeeinferior olivary nucleus1.00infobox
DLG1Bgeeinferior ganglion of vagus nerve1.00infobox
DLG1Bgeesubthalamic nucleus1.00infobox
DLG1Bgeeepithelium of colon1.00infobox
DLG1Bgeehair follicle1.00infobox
DLG1Bgeeexternal globus pallidus1.00infobox
DLG1BgeeBrodmann area 231.00infobox
DLG1Bgeetail of embryo1.00infobox
DLG1Bgeeglobus pallidus1.00infobox
DLG1Bgeemedullary collecting duct1.00infobox
DLG1Bgeevestibular membrane of cochlear duct1.00infobox
DLG1Bgeeprimary motor cortex1.00infobox
DLG1Bgeeconjunctival fornix1.00infobox
DLG1Bgeeolfactory tubercle1.00infobox
DLG1BgeePaneth cell1.00infobox
DLG1Bgeeutricle1.00infobox
DLG1Bgeecondyle1.00infobox
DLG1BioGPSMore reference expression data1.00infobox
DLG1Chr.Chromosome 3 (human)1.00infobox
DLG1Chr.Chromosome 16 (mouse)1.00infobox
DLG1DatabasesNCBI: entry; OMA: entry1.00infobox
DLG1End197,299,330 bp1.00infobox
DLG1End31,693,947 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DLG1 bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DLG1
    • Gene
    • Protein
    • Human
    • External
    • Homolog
    • Scaffold
    • Cell
    • Large
    • Location
    • Structure
    • Sap97
    • Chromosome
  • dlg1
    • Gene
    • Protein
    • Human
    • External
    • Homolog
    • Scaffold
    • Cell
    • Large
    • Location
    • Structure
    • Sap97
    • Chromosome
  • scaffold protein
    • Structure
    • Sap97
    • Human
    • External
    • Scaffold
    • Domain
    • Cell
    • Location
    • Chromosome
    • Bp
    • Chr
    • Function
  • gene
    • Human
    • Location
    • Protein
    • Chromosome
    • Sap97
    • Bp
    • Chr
    • External
    • Function
    • Homolog
    • Mouse
    • Scaffold
  • epithelial
    • Expressed
    • Endoplasmic
    • External
    • Ionotropic
    • Mouse
    • Reticulum
    • Binding
    • Brain
    • Cell
    • L27
    • Location
    • Membrane
  • endoplasmic reticulum
    • Ionotropic
    • Reticulum
    • Membrane
    • Plasma
    • Synaptic
    • Involved
    • Epithelial
    • Expressed
    • External
    • Mouse
    • Binding
    • Cell
  • synaptic
    • Endoplasmic
    • Ionotropic
    • Reticulum
    • Brain
    • Membrane
    • Plasma
    • Involved
    • Epithelial
    • Expressed
    • External
    • Mammalian
    • Mouse
  • function
    • External
    • Gene
    • Sap97's
    • Cell
    • Location
    • Membrane
    • Plasma
    • Structure
    • Chromosome
    • Bp
    • Chr
    • Human

Connections between topic areas Semantic bridges

For DLG1, one of the stronger structural bridges in this analysis connects DLG1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DLG1Overview · splits 18 ⟂ 10
DLG1Structure · splits 20 ⟂ 8
DLG1Function · splits 21 ⟂ 7

Map overview Semantic statistics

DLG1

Nodes28
Edges27
Triples179
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around DLG1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DLG1 · EN edition · Analysis: TopicsToTalkAbout

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