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NOS1: Function, Clinical significance & Interactions

Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene.

Language: English [EN]
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NOS1 topic overview

The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around NOS1.

Related topics
29
Source areas
4
Connected nodes
33
Extracted relationships
163
Concept neighborhoods
14
Bridge connections
33

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 18 topics
Clinical significance · 6 topics
Interactions · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.14.13.39
Aliases
NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4D1N, 4UCH, 4UH5, 4UH6, 4V3U, 5ADF, 5ADG, 5ADI, 5FVX, 5FVW, 5FVU, 5FVV
Band
12q24.22 · 5 F|5 57.29 cM
Bgee
body of tongue · biceps brachii · Skeletal muscle tissue of biceps brachii · Skeletal muscle tissue of rectus abdominis · muscle of thigh
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NOS1 connects Entity context

The extracted context around NOS1 shows recurring relationship patterns in the source. For example, NOS1 → arginine binding, arginine catabolic process, cadmium ion binding, calmodulin binding, calyx of Held, caveola, cell projection, cell redox homeostasis, cellular response to growth factor stimulus, cytoplasm, cytoskeleton, cytosol, dendritic spine, flavin adenine dinucleotide binding, FMN binding, heme binding, membrane, membrane raft, metal ion binding, mitochondrion Another extracted example is NOS1 → anterior amygdaloid area, biceps brachii, body of tongue, buccal mucosa cell, digastric muscle, dorsal tegmental nucleus, gastrocnemius muscle, lateral hypothalamus, mammillary body, muscle of thigh, pons, pontine nuclei, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, spinal ganglia, sternocleidomastoid muscle, subiculum, temporal muscle, vastus lateralis muscle, ventromedial nucleus. Use these groups to spot repeated connection types before inspecting the individual relationships.

NOS1

Top relations

Gene ontology · 78
NOS1 → arginine binding, arginine catabolic process, cadmium ion binding, calmodulin binding, calyx of Held, caveola, cell projection, cell redox homeostasis, cellular response to growth factor stimulus, cytoplasm, cytoskeleton, cytosol, dendritic spine, flavin adenine dinucleotide binding, FMN binding, heme binding, membrane, membrane raft, metal ion binding, mitochondrion
Bgee · 20
NOS1 → anterior amygdaloid area, biceps brachii, body of tongue, buccal mucosa cell, digastric muscle, dorsal tegmental nucleus, gastrocnemius muscle, lateral hypothalamus, mammillary body, muscle of thigh, pons, pontine nuclei, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, spinal ganglia, sternocleidomastoid muscle, subiculum, temporal muscle, vastus lateralis muscle, ventromedial nucleus
RNA expression pattern · 20
NOS1 → anterior amygdaloid area, biceps brachii, body of tongue, buccal mucosa cell, digastric muscle, dorsal tegmental nucleus, gastrocnemius muscle, lateral hypothalamus, mammillary body, muscle of thigh, pons, pontine nuclei, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, spinal ganglia, sternocleidomastoid muscle, subiculum, temporal muscle, vastus lateralis muscle, ventromedial nucleus
related to Function · 18
NOS1 → Both, EC1, Endothelial NOS, FAD, FMN, In, Inducible NOS, It, L-arginine, NADPH, Neuronal NOS, Nitric, NO, NOS, NOS2, NOS3, NOSs, Various
Band · 2
NOS1 → 12q24.22, 5 F|5 57.29 cM
Chr. · 2
NOS1 → Chromosome 12 (human), Chromosome 5 (mouse)
End · 2
NOS1 → 117,452,170 bp, 118,096,905 bp
related to Interactions · 2
NOS1 → DLG4, NOS1AP
1.14.13.39 · 1
NOS1 → ↗
Aliases · 1
NOS1 → NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp chr human band nitric oxide gene synthase chromosome 12 enzyme also location function neuronal activity mouse nos search 452

NOS1 relationships Subject–Predicate–Object triples

TTTA extracted 163 structured relationships around NOS1. Examples in this analysis include NOS1 → 1.14.13.39 → ↗ and NOS1 → Aliases → NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NOS11.14.13.391.00infobox
NOS1AliasesNOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 11.00infobox
NOS1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4D1N, 4UCH, 4UH5, 4UH6, 4V3U, 5ADF, 5ADG, 5ADI, 5FVX, 5FVW, 5FVU, 5FVV1.00infobox
NOS1Band12q24.221.00infobox
NOS1Band5 F|5 57.29 cM1.00infobox
NOS1Bgeebody of tongue1.00infobox
NOS1Bgeebiceps brachii1.00infobox
NOS1BgeeSkeletal muscle tissue of biceps brachii1.00infobox
NOS1BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
NOS1Bgeemuscle of thigh1.00infobox
NOS1Bgeepons1.00infobox
NOS1Bgeegastrocnemius muscle1.00infobox
NOS1Bgeespinal ganglia1.00infobox
NOS1Bgeebuccal mucosa cell1.00infobox
NOS1Bgeevastus lateralis muscle1.00infobox
NOS1Bgeeanterior amygdaloid area1.00infobox
NOS1Bgeepontine nuclei1.00infobox
NOS1Bgeesubiculum1.00infobox
NOS1Bgeedigastric muscle1.00infobox
NOS1Bgeetemporal muscle1.00infobox
NOS1Bgeemammillary body1.00infobox
NOS1Bgeedorsal tegmental nucleus1.00infobox
NOS1Bgeeventromedial nucleus1.00infobox
NOS1Bgeelateral hypothalamus1.00infobox
NOS1Bgeesternocleidomastoid muscle1.00infobox
NOS1BioGPSMore reference expression data1.00infobox
NOS1Chr.Chromosome 12 (human)1.00infobox
NOS1Chr.Chromosome 5 (mouse)1.00infobox
NOS1DatabasesNCBI: entry; OMA: entry1.00infobox
NOS1End117,452,170 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NOS1 bring nearby vocabulary together. In this analysis, examples include Oxide, Synthase and Neurotransmitter. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Chromosome
    • Human
    • Nitric
    • Oxide
    • Synthase
    • Bp
    • Chr
    • End
    • Mouse
    • Search
    • Nos1
  • nitric oxide synthases
    • Oxide
    • Synthase
    • Gene
    • Search
    • Nos1
    • Activity
    • Function
    • Location
    • Also
    • Chromosome
    • Enzyme
    • Human
  • nitric oxide
    • Oxide
    • Synthase
    • Gene
    • Search
    • Nos1
    • Activity
    • Function
    • Location
    • Also
    • Chromosome
    • Enzyme
    • Human
  • function
    • Search
    • Synthases
    • Activity
    • Location
    • Nos
    • Chromosome
    • Gene
    • Human
    • Nitric
    • Oxide
    • Synthase
    • Bp
  • NOS1
    • Oxide
    • Synthase
    • Neurotransmitter
    • Search
    • Activity
    • Function
    • Location
    • Nos
    • Chromosome
    • Human
    • Bp
    • Chr
  • nos1
    • Oxide
    • Synthase
    • Neurotransmitter
    • Search
    • Activity
    • Function
    • Location
    • Nos
    • Chromosome
    • Human
    • Bp
    • Chr
  • flavin adenine dinucleotide
    • Fmn
    • Tetrahydrobiopterin
    • Mouse
    • Muscle
    • Neurotransmitter
    • Search
    • Synthases
    • Tissue
    • Function
    • Location
    • Neuronal
    • Gene
  • flavin mononucleotide
    • Fmn
    • Tetrahydrobiopterin
    • Mouse
    • Muscle
    • Neurotransmitter
    • Search
    • Synthases
    • Tissue
    • Function
    • Location
    • Neuronal
    • Gene

Connections between topic areas Semantic bridges

For NOS1, one of the stronger structural bridges in this analysis connects NOS1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NOS1Function · splits 15 ⟂ 19
NOS1Clinical significance · splits 27 ⟂ 7
NOS1Interactions · splits 30 ⟂ 4
NOS1Overview · splits 31 ⟂ 3

Map overview Semantic statistics

NOS1

Nodes34
Edges33
Triples163
Avg. degree1.94
Density0.058824
Components1

Source & methodology

TTTA analyzes the structure around NOS1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NOS1 · EN edition · Analysis: TopicsToTalkAbout

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