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CASK: Interactions, Function & Clinical importance

Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2 (CAMGUK protein 2), calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2. CASK gene mutations are the cause of XL-ID with or without nystagmus and MICPCH, an…

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CASK topic overview

The analysis highlights Interactions, Function and Clinical importance as prominent areas in the source structure around CASK.

Related topics
27
Source areas
5
Connected nodes
32
Extracted relationships
133
Concept neighborhoods
10
Bridge connections
32

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 15 topics
Clinical importance · 4 topics
Function · 4 topics
Overview · 3 topics
Gene · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1
↗
Aliases
CASK, CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, calcium/calmodulin-dependent serine protein kinase (MAGUK family), calcium/calmodulin dependent serine protein kina…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KGD, 1KWA, 1ZL8, 3C0G, 3C0H, 3C0I, 3MFR, 3MFS, 3MFT, 3MFU, 3TAC
Band
Xp11.4 · X A1.1|X 8.43 cM
Bgee
buccal mucosa cell · hair follicle · duodenum · jejunal mucosa · pancreatic ductal cell
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

  • Protein
  • Gene
  • MICPCH Mental retardation and microcephaly with pontine and cerebellar hypoplasia

Gene

Function

Clinical importance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CASK connects Entity context

The extracted context around CASK shows recurring relationship patterns in the source. For example, CASK → actin cytoskeleton, ATP binding, basement membrane, basolateral plasma membrane, calcium ion import, calmodulin binding, cell adhesion, cell-cell junction, ciliary membrane, cytoplasm, cytosol, focal adhesion, GDP metabolic process, GMP metabolic process, guanylate kinase activity, kinase activity, membrane, negative regulation of cell-matrix adhesion, negative regulation of cellular response to growth factor stimulus, negative regulation of keratinocyte proliferation Another extracted example is CASK → Achilles tendon, buccal mucosa cell, condyle, conjunctival fornix, duodenum, fossa, ganglionic eminence, genital tubercle, hair follicle, Ileal epithelium, jejunal mucosa, optic nerve, pancreatic ductal cell, Paneth cell, Rostral migratory stream, superior vestibular nucleus, tail of embryo, trigeminal ganglion, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

CASK

Top relations

Gene ontology · 42
CASK → actin cytoskeleton, ATP binding, basement membrane, basolateral plasma membrane, calcium ion import, calmodulin binding, cell adhesion, cell-cell junction, ciliary membrane, cytoplasm, cytosol, focal adhesion, GDP metabolic process, GMP metabolic process, guanylate kinase activity, kinase activity, membrane, negative regulation of cell-matrix adhesion, negative regulation of cellular response to growth factor stimulus, negative regulation of keratinocyte proliferation
Bgee · 19
CASK → Achilles tendon, buccal mucosa cell, condyle, conjunctival fornix, duodenum, fossa, ganglionic eminence, genital tubercle, hair follicle, Ileal epithelium, jejunal mucosa, optic nerve, pancreatic ductal cell, Paneth cell, Rostral migratory stream, superior vestibular nucleus, tail of embryo, trigeminal ganglion, ventricular zone
RNA expression pattern · 19
CASK → Achilles tendon, buccal mucosa cell, condyle, conjunctival fornix, duodenum, fossa, ganglionic eminence, genital tubercle, hair follicle, Ileal epithelium, jejunal mucosa, optic nerve, pancreatic ductal cell, Paneth cell, Rostral migratory stream, superior vestibular nucleus, tail of embryo, trigeminal ganglion, ventricular zone
related to External links · 11
CASK → Australia, CASK Research Foundation, CASK-related, Foundation, Human CASK, MICPCH, MICPCHAngelina CASK Neurological Research, Project CASK, UCSC Genome Browser, UK, United States
related to Clinical importance · 9
CASK → As, Females, It, Males, Research, The, These, This, X-linked
related to Interactions · 3
CASK → KCNJ4APBA1ATP2B4CINAP, RPH3ASDC2, TBR1DLG1DLG4F11
Band · 2
CASK → X A1.1|X 8.43 cM, Xp11.4
Chr. · 2
CASK → X chromosome (human), X chromosome (mouse)
End · 2
CASK → 13,717,606 bp, 41,923,554 bp
2.7.11.1 · 1
CASK → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein bp human chr band chromosome micpch location mutations calcium serine kinase function synaptic including disorders x-linked membrane mouse

CASK relationships Subject–Predicate–Object triples

TTTA extracted 133 structured relationships around CASK. Examples in this analysis include CASK → 2.7.11.1 → ↗ and CASK → Aliases → CASK, CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, calcium/calmodulin-dependent serine protein kinase (MAGUK family), calcium/calmodulin dependent serine protein kina…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CASK2.7.11.1↗1.00infobox
CASKAliasesCASK, CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, calcium/calmodulin-dependent serine protein kinase (MAGUK family), calcium/calmodulin dependent serine protein kina…1.00infobox
CASKAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KGD, 1KWA, 1ZL8, 3C0G, 3C0H, 3C0I, 3MFR, 3MFS, 3MFT, 3MFU, 3TAC1.00infobox
CASKBandXp11.41.00infobox
CASKBandX A1.1|X 8.43 cM1.00infobox
CASKBgeebuccal mucosa cell1.00infobox
CASKBgeehair follicle1.00infobox
CASKBgeeduodenum1.00infobox
CASKBgeejejunal mucosa1.00infobox
CASKBgeepancreatic ductal cell1.00infobox
CASKBgeeoptic nerve1.00infobox
CASKBgeeAchilles tendon1.00infobox
CASKBgeeganglionic eminence1.00infobox
CASKBgeeventricular zone1.00infobox
CASKBgeesuperior vestibular nucleus1.00infobox
CASKBgeegenital tubercle1.00infobox
CASKBgeeIleal epithelium1.00infobox
CASKBgeetail of embryo1.00infobox
CASKBgeeRostral migratory stream1.00infobox
CASKBgeecondyle1.00infobox
CASKBgeeconjunctival fornix1.00infobox
CASKBgeefossa1.00infobox
CASKBgeetrigeminal ganglion1.00infobox
CASKBgeePaneth cell1.00infobox
CASKBioGPSMore reference expression data1.00infobox
CASKChr.X chromosome (human)1.00infobox
CASKChr.X chromosome (mouse)1.00infobox
CASKDatabasesNCBI: entry; OMA: entry1.00infobox
CASKEnd41,923,554 bp1.00infobox
CASKEnd13,717,606 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CASK bring nearby vocabulary together. In this analysis, examples include Gene, Disorders and Micpch. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CASK
    • Gene
    • Disorders
    • Micpch
    • Protein
    • Expression
    • Function
    • Research
    • Location
    • Mutations
    • Human
    • Activity
    • Calmodulin
  • cask
    • Gene
    • Disorders
    • Micpch
    • Protein
    • Expression
    • Function
    • Research
    • Location
    • Mutations
    • Human
    • Activity
    • Calmodulin
  • gene
    • Location
    • Protein
    • Human
    • Calcium
    • Function
    • Kinase
    • Serine
    • Chromosome
    • Micpch
    • Bp
    • Chr
    • Activity
  • synaptic
    • Expression
    • Activity
    • Calmodulin
    • Family
    • Guanylate
    • Humans
    • Membrane
    • Mouse
    • Plasma
    • Search
    • Protein
    • Calcium
  • protein
    • Kinase
    • Serine
    • Activity
    • Calmodulin
    • Family
    • Guanylate
    • Search
    • Function
    • Synaptic
    • Chromosome
    • Location
    • Bp
  • function
    • Activity
    • Calmodulin
    • Family
    • Search
    • Expression
    • Kinase
    • Serine
    • Chromosome
    • Location
    • Bp
    • Chr
    • External
  • x chromosome
    • Bp
    • Human
    • Band
    • Location
    • Family
    • Mouse
    • Search
    • Function
    • Kinase
    • Serine
    • External
    • Gene
  • micpch
    • Neurological
    • Research
    • Disorders
    • Including
    • External
    • Activity
    • Calmodulin
    • Family
    • Search
    • Function
    • Serine
    • X-linked

Connections between topic areas Semantic bridges

For CASK, one of the stronger structural bridges in this analysis connects CASK with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CASK — Interactions · splits 17 ⟂ 16
CASK — Function · splits 28 ⟂ 5
CASK — Clinical importance · splits 28 ⟂ 5
CASK — Overview · splits 29 ⟂ 4

Map overview Semantic statistics

CASK

Nodes33
Edges32
Triples133
Avg. degree1.94
Density0.060606
Components1

Source & methodology

TTTA analyzes the structure around CASK to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Clinical importance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CASK · EN edition · Analysis: TopicsToTalkAbout

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