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Cellular senescence

Cellular senescence is a phenomenon characterized by the cessation of cell division. In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent. This process called the Hayflick limit is also…

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Characteristics of senescent cells

SkinAdipose tissueP14arfP53INK4A/RB
38 related topics

Cellular mechanisms

DNA damageTelomeresReactive oxygen speciesOncogenesCell fusion
34 related topics

Cellular senescence in mammalian disease

TissuesVertebratesAlzheimer's diseaseAmyotrophic lateral sclerosisEndocrine disorders
21 related topics

Clearance of senescent cells by the immune system

InnateAdaptive immune systemNatural killer cellsPhagocyticNeutrophils
18 related topics

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Overview

Cellular mechanisms

Signaling pathways

Characteristics of senescent cells

Clearance of senescent cells by the immune system

Transient senescence

Cellular senescence in mammalian disease

Senolytic drugs

Organisms lacking senescence

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Cellular senescence

Nodes166
Edges165
Triples85
Avg. degree1.99
Density0.012048
Components1

How this topic connects Entity context

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Cellular senescence

Top relations

related to Stress response and DNA damage · 18
Cellular senescence → ATM, ATR DNA, Cells, DDR, Depending, Depletion, DNA, DSBs, It, Mechanistically, Mutations, NAD, Normally, ROS, Senescent, Such, The, The DNA
related to Role of oncogenes · 16
Cellular senescence → As, BRAFV600E, E2F, Further, IGFBP7, INK4a/Rb, Interestingly, MAPK, N-Ras, OIS, Ras, Researchers, The, There, This, UV-irradiated HGF/SF-transgenic
related to Role of telomeres · 9
Cellular senescence → After, DNA, Recently, RNA, Telomeres, The, Theoretically, This, TRF2
related to Signaling pathways · 7
Cellular senescence → Both, Cdk, E2F1, G1, There, This, Without Cdk
related to Transient senescence · 7
Cellular senescence → Cellular, During, It, Senescence, They, This, When
related to Organisms lacking senescence · 6
Cellular senescence → As, Cellular, DNA, How, In, Somatic
related to Cellular senescence in mammalian disease · 5
Cellular senescence → Alzheimer's, Amyotrophic, Biomarkers, The, Transplantation
related to Characteristics of senescent cells · 4
Cellular senescence → Cellular Senescence Program Network, For, Senescent, Transformation
related to External links · 4
Cellular senescence → Cellular, Media, Wikimedia Commons, Wiktionary-logo-en-v2
is a · 1
Cellular senescence → phenomenon characterized by the cessation of cell division

Important terminology Word statistics

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Important terminology

cells senescence senescent cell cellular dna p53 sasp aging cycle phenotype immune damage system also p16ink4a including factors response growth

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Cellular senescenceis aphenomenon characterized by the cessation of cell division0.90text
cellular hypertrophyinstance ofcauses phenotypes characteristic of senescent cells0.80text
SASPinstance ofcauses phenotypes characteristic of senescent cells0.80text
lysosomal hyperfunctionsinstance ofcauses phenotypes characteristic of senescent cells0.80text
progerininstance oftelomere shortening activates extensive alterations in alternative RNA splicing that produce senescent toxins0.80text
which degrades tissueinstance oftelomere shortening activates extensive alterations in alternative RNA splicing that produce senescent toxins0.80text
makes it more prone to failure.Role of oncogenesBRAFV600Einstance oftelomere shortening activates extensive alterations in alternative RNA splicing that produce senescent toxins0.80text
Ras are two oncogenes implicated in cellular senescenceinstance oftelomere shortening activates extensive alterations in alternative RNA splicing that produce senescent toxins0.80text
makes it more prone to failureinstance oftelomere shortening activates extensive alterations in alternative RNA splicing that produce senescent toxins0.80text
Cellular senescencerelated to Cellular senescence in mammalian diseaseTransplantation0.60section
Cellular senescencerelated to Cellular senescence in mammalian diseaseBiomarkers0.60section
Cellular senescencerelated to Cellular senescence in mammalian diseaseThe0.60section

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