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Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.
The analysis highlights Interactions, Function and Overview as prominent areas in the source structure around E2F1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around E2F1 shows recurring relationship patterns in the source. For example, E2F1 → anoikis, apoptotic process, cell cycle, cellular response to fatty acid, cellular response to hypoxia, cellular response to nerve growth factor stimulus, cellular response to xenobiotic stimulus, centrosome, cis-regulatory region sequence-specific DNA binding, cytoplasm, DNA binding, DNA damage checkpoint signaling, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, forebrain development, intrinsic apoptotic signaling pathway by p53 class mediator, intrinsic apoptotic signaling pathway in response to DNA damage Another extracted example is E2F1 → ARID3A, CUL1, Cyclin A1, Cyclin A2, GTF2H1, MDM4, NCOA6, NDN, NPDC1, PHB, PURA, RB1, RBL1, SKP2, SP1, SP2, SP3, SP4, TFDP1TOPBP1, TP53BP1. Use these groups to spot repeated connection types before inspecting the individual relationships.
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bp protein transcription human gene chr band e2f factor chromosome 20 location mouse cell dna binding function external family proteins
TTTA extracted 136 structured relationships around E2F1. Examples in this analysis include E2F1 → Aliases → E2F1, E2F-1, RBAP1, RBBP3, RBP3, E2F transcription factor 1 and E2F1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H24, 1O9K, 2AZE. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| E2F1 | Aliases | E2F1, E2F-1, RBAP1, RBBP3, RBP3, E2F transcription factor 1 | 1.00 | infobox |
| E2F1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H24, 1O9K, 2AZE | 1.00 | infobox |
| E2F1 | Band | 20q11.22 | 1.00 | infobox |
| E2F1 | Band | 2 H1|2 76.79 cM | 1.00 | infobox |
| E2F1 | Bgee | ganglionic eminence | 1.00 | infobox |
| E2F1 | Bgee | secondary oocyte | 1.00 | infobox |
| E2F1 | Bgee | ventricular zone | 1.00 | infobox |
| E2F1 | Bgee | gonad | 1.00 | infobox |
| E2F1 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| E2F1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| E2F1 | Bgee | prefrontal cortex | 1.00 | infobox |
| E2F1 | Bgee | testicle | 1.00 | infobox |
| E2F1 | Bgee | bone marrow | 1.00 | infobox |
| E2F1 | Bgee | putamen | 1.00 | infobox |
| E2F1 | Bgee | zygote | 1.00 | infobox |
| E2F1 | Bgee | ectoderm | 1.00 | infobox |
| E2F1 | Bgee | otic vesicle | 1.00 | infobox |
| E2F1 | Bgee | otic placode | 1.00 | infobox |
| E2F1 | Bgee | primary oocyte | 1.00 | infobox |
| E2F1 | Bgee | fetal liver hematopoietic progenitor cell | 1.00 | infobox |
| E2F1 | Bgee | saccule | 1.00 | infobox |
| E2F1 | Bgee | gastrula | 1.00 | infobox |
| E2F1 | BioGPS | More reference expression data | 1.00 | infobox |
| E2F1 | Chr. | Chromosome 20 (human) | 1.00 | infobox |
| E2F1 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| E2F1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| E2F1 | End | 33,686,385 bp | 1.00 | infobox |
| E2F1 | End | 154,411,812 bp | 1.00 | infobox |
| E2F1 | Ensembl | ENSG00000101412 | 1.00 | infobox |
| E2F1 | Entrez | 1869 | 1.00 | infobox |
The concept neighborhoods around E2F1 bring nearby vocabulary together. In this analysis, examples include Factor, Gene and Transcription. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For E2F1, one of the stronger structural bridges in this analysis connects E2F1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around E2F1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — E2F1 · EN edition · Analysis: TopicsToTalkAbout
