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NKG2D

NKG2D is an activating receptor (transmembrane protein) belonging to the NKG2 family of C-type lectin-like receptors. NKG2D is encoded by KLRK1 (killer cell lectin like receptor K1) gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice and chromosome 12 in humans. In mice, it is expressed by NK cells, NK1.1+ T cells, γδ T…

NKG2D ligands, Structure & Function

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NKG2D ligands

22 related topics

Structure

8 related topics

Function

5 related topics

NKG2D and T cells

4 related topics

Key facts & relationships

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Aliases
KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D, natural killer group 2D, killer cell lectin-like receptor K1, killer cell lectin like receptor K1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KCG, 4PDC, 1HYR, 1MPU, 4S0U
Band
12p13.2 · 6 F3|6 63.44 cM
Bgee
granulocyte · spleen · lymph node · blood · appendix
BioGPS
n/a
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

Topics to explore

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Overview

Structure

NKG2D ligands

Function

NKG2D signalling

NKG2D and NK cells

NKG2D and T cells

Advanced semantic analysis

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Map overview Semantic statistics

NKG2D

Nodes58
Edges57
Triples214
Avg. degree1.97
Density0.034483
Components1

How this topic connects Entity context

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NKG2D

Top relations

Gene ontology · 33
NKG2D → adaptive immune response, carbohydrate binding, cell differentiation, cell surface, cellular response to lipopolysaccharide, defense response to Gram-positive bacterium, external side of plasma membrane, immune system process, innate immune response, integral component of membrane, integral component of plasma membrane, kinase binding, membrane, MHC class I protein binding, MHC class Ib receptor activity, natural killer cell activation, natural killer cell mediated cytotoxicity, negative regulation of GTPase activity, negative regulation of natural killer cell chemotaxis, plasma membrane
related to NKG2D ligand regulation · 22
NKG2D → Additionally, Also, ATM, ATR, AUF1, Chk1, Chk2, DDR, DNA, For, For MICA, However, In, Ligation, MIC, On, One, Reat1, RNA, ULBP4
related to NKG2D signalling · 19
NKG2D → DAP, DAP10, Grb, Grb2, IFN-γ, In, NK, NKG2D-DAP12, PI3K, PI3K-AKT, Syk, The, Therefore, This, Tyr-X-X-Meth, Upon, When NKG2D, YXXM, ZAP70
Bgee · 17
NKG2D → appendix, blood, bone marrow, corneal stroma, extensor digitorum longus muscle, gallbladder, granulocyte, interventricular septum, lymph node, mesenteric lymph nodes, morula, mucosa of transverse colon, plantaris muscle, spleen, superior surface of tongue, testicle, upper lobe of left lung
RNA expression pattern · 17
NKG2D → appendix, blood, bone marrow, corneal stroma, extensor digitorum longus muscle, gallbladder, granulocyte, interventricular septum, lymph node, mesenteric lymph nodes, morula, mucosa of transverse colon, plantaris muscle, spleen, superior surface of tongue, testicle, upper lobe of left lung
related to Structure · 16
NKG2D → By, DAP10, DAP12, Each NKG2D, Grb2, Grb2-Vav1, Human NKG2D, In, ITAM, NKG2D-L, NKG2D-S, PI3K, Syk, This, Vav1, Zap70
related to NKG2D and T cells · 11
NKG2D → CD28, CD8, Co-stimulation, For, IL15-receptor, In, Key, Mcl-1, T-bet, TCR, Upregulation
related to NKG2D ligands · 11
NKG2D → All NKG2D, Among, ATM, ATR, DNA, Genotoxic, MHC, MIC, RAET1/ULBP, Their, These
related to Role in senescent cell removal · 8
NKG2D → As, DNA, Interventions, MICA, Natural Killer, NK-mediated, Specifically, ULBP2
related to Role in tumor control · 7
NKG2D → As, However, NK, NKG2DL, TGF-β, They, Tumor

Important terminology Word statistics

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Important terminology

cells cell nk receptor ligands dap10 mice expression protein surface human ligand complex 12 bp proteins killer cd8 chromosome mic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NKG2DAliasesKLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D, natural killer group 2D, killer cell lectin-like receptor K1, killer cell lectin like receptor K11.00infobox
NKG2DAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KCG, 4PDC, 1HYR, 1MPU, 4S0U1.00infobox
NKG2DBand12p13.21.00infobox
NKG2DBand6 F3|6 63.44 cM1.00infobox
NKG2DBgeegranulocyte1.00infobox
NKG2DBgeespleen1.00infobox
NKG2DBgeelymph node1.00infobox
NKG2DBgeeblood1.00infobox
NKG2DBgeeappendix1.00infobox
NKG2DBgeegallbladder1.00infobox
NKG2DBgeeupper lobe of left lung1.00infobox
NKG2DBgeemucosa of transverse colon1.00infobox
NKG2DBgeebone marrow1.00infobox
NKG2DBgeetesticle1.00infobox
NKG2DBgeesuperior surface of tongue1.00infobox
NKG2DBgeeplantaris muscle1.00infobox
NKG2DBgeeextensor digitorum longus muscle1.00infobox
NKG2DBgeemorula1.00infobox
NKG2DBgeecorneal stroma1.00infobox
NKG2DBgeemesenteric lymph nodes1.00infobox
NKG2DBgeeinterventricular septum1.00infobox
NKG2DBioGPSn/a1.00infobox
NKG2DChr.Chromosome 12 (human)1.00infobox
NKG2DChr.Chromosome 6 (mouse)1.00infobox
NKG2DDatabasesNCBI: entry; OMA: entry1.00infobox
NKG2DEnd10,391,874 bp1.00infobox
NKG2DEnd129,600,827 bp1.00infobox
NKG2DEnsemblENSG000002138091.00infobox
NKG2DEntrez229141.00infobox
NKG2DExternal IDsOMIM: 611817; MGI: 1196250; GeneCards: KLRK11.00infobox

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