NKG2D

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NKG2D topic overview

The analysis highlights NKG2D ligands, Structure and Function as prominent areas in the source structure around NKG2D.

Related topics: 50
Source areas: 7
Connected nodes: 57
Extracted relationships: 214
Concept neighborhoods: 20
Bridge connections: 57

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

NKG2D ligands · 22 topics

Overview · 8 topics

Structure · 8 topics

Function · 5 topics

NKG2D and T cells · 4 topics

NKG2D and NK cells · 2 topics

NKG2D signalling · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D, natural killer group 2D, killer cell lectin-like receptor K1, killer cell lectin like receptor K1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KCG, 4PDC, 1HYR, 1MPU, 4S0U
Band: 12p13.2 · 6 F3|6 63.44 cM
Bgee: granulocyte · spleen · lymph node · blood · appendix
BioGPS: n/a
Chr.: Chromosome 12 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

NKG2
C-type lectin-like receptors C-type lectin
NK cells Natural killer cell
NK1.1+ T cells Natural killer T cell
Γδ T cells Gamma delta T cell
CD8+ αβ T cells Cytotoxic T cell
Macrophages Macrophage
Induced-self proteins Induced-self antigen

Structure

DAP10 HCST (gene)
PI3K Phosphoinositide 3-kinase
Grb2
Vav1
DAP12 TYROBP
ITAM motif Immunoreceptor tyrosine-based activation motif
Syk
Zap70

NKG2D ligands

ATM Ataxia telangiectasia mutated
ATR Ataxia telangiectasia and Rad3 related
MICA MHC class I polypeptide-related sequence A
MICB
RAET1E/ULBP4 RAET1E
RAET1G/ULBP5 RAET1G
ULBP2
RAET1/ULBP1 ULBP1
RAET1L/ULBP6 RAET1L
RAET1N/ULBP3 ULBP3
Rae-1 Rae-1 family
H60 H60 family
MULT-1 Murine UL16 binding protein-like transcript
Senescent cells Cellular senescence
RNA splicing
Cell stress Cell stress response
Infection
Oxidative stress
ATM ATM serine/threonine kinase
Chk1 CHEK1
Chk2 CHEK2
AUF1 HNRPD

Function

Cancer
Cytomegalovirus
UL16 UL16?action=edit&redlink=1
Metalloproteases Metalloprotease
Senolytic

NKG2D signalling

PI3K-AKT pathway

NKG2D and NK cells

Innate immunity Innate immune system
IL-15 receptor Interleukin-15 receptor

NKG2D and T cells

T cells T cell
T cell receptors T-cell receptor
Co-stimulation
Cytokines Cytokine

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NKG2D connects Entity context

The extracted context around NKG2D shows recurring relationship patterns in the source. For example, NKG2D → adaptive immune response, carbohydrate binding, cell differentiation, cell surface, cellular response to lipopolysaccharide, defense response to Gram-positive bacterium, external side of plasma membrane, immune system process, innate immune response, integral component of membrane, integral component of plasma membrane, kinase binding, membrane, MHC class I protein binding, MHC class Ib receptor activity, natural killer cell activation, natural killer cell mediated cytotoxicity, negative regulation of GTPase activity, negative regulation of natural killer cell chemotaxis, plasma membrane Another extracted example is NKG2D → Additionally, Also, ATM, ATR, AUF1, Chk1, Chk2, DDR, DNA, For, For MICA, However, In, Ligation, MIC, On, One, Reat1, RNA, ULBP4. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 33

NKG2D → adaptive immune response, carbohydrate binding, cell differentiation, cell surface, cellular response to lipopolysaccharide, defense response to Gram-positive bacterium, external side of plasma membrane, immune system process, innate immune response, integral component of membrane, integral component of plasma membrane, kinase binding, membrane, MHC class I protein binding, MHC class Ib receptor activity, natural killer cell activation, natural killer cell mediated cytotoxicity, negative regulation of GTPase activity, negative regulation of natural killer cell chemotaxis, plasma membrane

related to NKG2D ligand regulation · 22

NKG2D → Additionally, Also, ATM, ATR, AUF1, Chk1, Chk2, DDR, DNA, For, For MICA, However, In, Ligation, MIC, On, One, Reat1, RNA, ULBP4

related to NKG2D signalling · 19

NKG2D → DAP, DAP10, Grb, Grb2, IFN-γ, In, NK, NKG2D-DAP12, PI3K, PI3K-AKT, Syk, The, Therefore, This, Tyr-X-X-Meth, Upon, When NKG2D, YXXM, ZAP70

Bgee · 17

NKG2D → appendix, blood, bone marrow, corneal stroma, extensor digitorum longus muscle, gallbladder, granulocyte, interventricular septum, lymph node, mesenteric lymph nodes, morula, mucosa of transverse colon, plantaris muscle, spleen, superior surface of tongue, testicle, upper lobe of left lung

RNA expression pattern · 17

related to Structure · 16

NKG2D → By, DAP10, DAP12, Each NKG2D, Grb2, Grb2-Vav1, Human NKG2D, In, ITAM, NKG2D-L, NKG2D-S, PI3K, Syk, This, Vav1, Zap70

related to NKG2D and T cells · 11

NKG2D → CD28, CD8, Co-stimulation, For, IL15-receptor, In, Key, Mcl-1, T-bet, TCR, Upregulation

related to NKG2D ligands · 11

NKG2D → All NKG2D, Among, ATM, ATR, DNA, Genotoxic, MHC, MIC, RAET1/ULBP, Their, These

related to Role in senescent cell removal · 8

NKG2D → As, DNA, Interventions, MICA, Natural Killer, NK-mediated, Specifically, ULBP2

related to Role in tumor control · 7

NKG2D → As, However, NK, NKG2DL, TGF-β, They, Tumor

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells cell nk receptor ligands dap10 mice expression protein surface human ligand complex 12 bp proteins killer cd8 chromosome mic

NKG2D relationships Subject–Predicate–Object triples

TTTA extracted 214 structured relationships around NKG2D. Examples in this analysis include NKG2D → Aliases → KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D, natural killer group 2D, killer cell lectin-like receptor K1, killer cell lectin like receptor K1 and NKG2D → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KCG, 4PDC, 1HYR, 1MPU, 4S0U. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
NKG2D	Aliases	KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D, natural killer group 2D, killer cell lectin-like receptor K1, killer cell lectin like receptor K1	1.00	infobox
NKG2D	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KCG, 4PDC, 1HYR, 1MPU, 4S0U	1.00	infobox
NKG2D	Band	12p13.2	1.00	infobox
NKG2D	Band	6 F3\|6 63.44 cM	1.00	infobox
NKG2D	Bgee	granulocyte	1.00	infobox
NKG2D	Bgee	spleen	1.00	infobox
NKG2D	Bgee	lymph node	1.00	infobox
NKG2D	Bgee	blood	1.00	infobox
NKG2D	Bgee	appendix	1.00	infobox
NKG2D	Bgee	gallbladder	1.00	infobox
NKG2D	Bgee	upper lobe of left lung	1.00	infobox
NKG2D	Bgee	mucosa of transverse colon	1.00	infobox
NKG2D	Bgee	bone marrow	1.00	infobox
NKG2D	Bgee	testicle	1.00	infobox
NKG2D	Bgee	superior surface of tongue	1.00	infobox
NKG2D	Bgee	plantaris muscle	1.00	infobox
NKG2D	Bgee	extensor digitorum longus muscle	1.00	infobox
NKG2D	Bgee	morula	1.00	infobox
NKG2D	Bgee	corneal stroma	1.00	infobox
NKG2D	Bgee	mesenteric lymph nodes	1.00	infobox
NKG2D	Bgee	interventricular septum	1.00	infobox
NKG2D	BioGPS	n/a	1.00	infobox
NKG2D	Chr.	Chromosome 12 (human)	1.00	infobox
NKG2D	Chr.	Chromosome 6 (mouse)	1.00	infobox
NKG2D	Databases	NCBI: entry; OMA: entry	1.00	infobox
NKG2D	End	10,391,874 bp	1.00	infobox
NKG2D	End	129,600,827 bp	1.00	infobox
NKG2D	Ensembl	ENSG00000213809	1.00	infobox
NKG2D	Entrez	22914	1.00	infobox
NKG2D	External IDs	OMIM: 611817; MGI: 1196250; GeneCards: KLRK1	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NKG2D bring nearby vocabulary together. In this analysis, examples include Cells, Ligands and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

NKG2D
- Cells
- Ligands
- Receptor
- Expression
- Cell
- Protein
- Nk
- Ligand
- Mice
- Surface
- Dap10
- Also
nkg2d
- Cells
- Ligands
- Receptor
- Expression
- Cell
- Protein
- Nk
- Ligand
- Mice
- Surface
- Dap10
- Also
nk cells
- Nk
- Nkg2d
- Ligands
- Receptor
- Cd8
- Senescent
- Also
- Tumor
- Surface
- Activation
- Immune
- Signaling
nk1.1+ t cells
- Nk
- Nkg2d
- Ligands
- Receptor
- Cd8
- Senescent
- Also
- Tumor
- Surface
- Natural
- Immune
- Killer
γδ t cells
- Nk
- Nkg2d
- Ligands
- Receptor
- Cd8
- Senescent
- Also
- Tumor
- Surface
- Natural
- Immune
- Killer
cd8+ αβ t cells
- Nk
- Nkg2d
- Ligands
- Receptor
- Cd8
- Cells
- Senescent
- Also
- Tumor
- Surface
- Signaling
- Natural
senescent cells
- Nk
- Nkg2d
- Ligands
- Receptor
- Cd8
- Senescent
- Also
- Surface
- Tumor
- Ulbp
- Dna
- Pathway
cell stress
- Dna
- Surface
- Killer
- Nk
- Receptor
- Klrk1
- Natural
- Ligands
- Gene
- Nkg2d
- Chromosome
- Regulation

Connections between topic areas Semantic bridges

For NKG2D, one of the stronger structural bridges in this analysis connects NKG2D with NKG2D ligands. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

NKG2D — NKG2D ligands · splits 35 ⟂ 23

NKG2D — Overview · splits 49 ⟂ 9

NKG2D — Structure · splits 49 ⟂ 9

NKG2D — Function · splits 52 ⟂ 6

NKG2D — NKG2D and T cells · splits 53 ⟂ 5

NKG2D — NKG2D and NK cells · splits 55 ⟂ 3

Map overview Semantic statistics

NKG2D

Nodes58

Edges57

Triples214

Avg. degree1.97

Density0.034483

Components1

Source & methodology

TTTA analyzes the structure around NKG2D to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as NKG2D ligands, Structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NKG2D · EN edition · Analysis: TopicsToTalkAbout