Cyclin-dependent kinase 4

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Cyclin-dependent kinase 4 topic overview

The analysis highlights Interactions, Clinical significance and Overview as prominent areas in the source structure around Cyclin-dependent kinase 4.

Related topics: 33
Source areas: 4
Connected nodes: 37
Extracted relationships: 116
Concept neighborhoods: 14
Bridge connections: 37

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 13 topics

Overview · 13 topics

Clinical significance · 4 topics

Function · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.22: ↗
Aliases: CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK
Band: 12q14.1
Bgee: ganglionic eminence · ventricular zone · stromal cell of endometrium · right adrenal gland · right ovary
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Enzyme
Gene
Cyclin-dependent kinase
Serine/threonine kinases Serine/threonine kinase
Cell cycle
G1/S transition
Phosphorylation Protein phosphorylation
E2F1
S-phase
Cyclins Cyclin
Cyclin D
Cyclin kinase inhibitors Cyclin-dependent kinase inhibitor protein
Therapeutic target Drug target

Function

Retinoblastoma gene
Retinoblastoma (RB) protein family including RB1 Retinoblastoma protein
E2F

Clinical significance

Interactions

Interact Protein-protein interaction
CDC37
CDKN1B
CDKN2B
CDKN2C
CEBPA
CCND1 Cyclin D1
CCND3 Cyclin D3
DBNL Drebrin-like
MyoD
P16 P16 (gene)
PCNA
SERTAD1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Cyclin-dependent kinase 4 connects Entity context

The extracted context around Cyclin-dependent kinase 4 shows recurring relationship patterns in the source. For example, Cyclin-dependent kinase 4 → adipose tissue development, animal organ regeneration, ATP binding, bicellular tight junction, cell cycle, cell division, cellular response to insulin stimulus, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to phorbol 13-acetate 12-myristate, chromatin, circadian rhythm, cyclin binding, cyclin D2-CDK4 complex, cyclin-dependent protein kinase holoenzyme complex, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, cytoplasm, cytosol Another extracted example is Cyclin-dependent kinase 4 → CCND1, CCND3, CDC37, CDKN1B, CDKN2B, CDKN2C, CEBPA, Cyclin-dependent, DBNL, MyoD, P16, PCNA. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 63

Cyclin-dependent kinase 4 → adipose tissue development, animal organ regeneration, ATP binding, bicellular tight junction, cell cycle, cell division, cellular response to insulin stimulus, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to phorbol 13-acetate 12-myristate, chromatin, circadian rhythm, cyclin binding, cyclin D2-CDK4 complex, cyclin-dependent protein kinase holoenzyme complex, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, cytoplasm, cytosol

related to Interactions · 12

Cyclin-dependent kinase 4 → CCND1, CCND3, CDC37, CDKN1B, CDKN2B, CDKN2C, CEBPA, Cyclin-dependent, DBNL, MyoD, P16, PCNA

Bgee · 10

Cyclin-dependent kinase 4 → ganglionic eminence, left adrenal cortex, left adrenal gland, left ovary, right adrenal cortex, right adrenal gland, right ovary, smooth muscle tissue, stromal cell of endometrium, ventricular zone

RNA expression pattern · 10

2.7.11.22 · 1

Cyclin-dependent kinase 4 → ↗

Aliases · 1

Cyclin-dependent kinase 4 → CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4

Available structures · 1

Cyclin-dependent kinase 4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK

Band · 1

Cyclin-dependent kinase 4 → 12q14.1

BioGPS · 1

Cyclin-dependent kinase 4 → More reference expression data

Chr. · 1

Cyclin-dependent kinase 4 → Chromosome 12 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cdk4 cell rb kinase cyclin g1 cycle gene protein proteins inhibitors cyclin-dependent progression cancer complex transition human phosphorylation role activity

Cyclin-dependent kinase 4 relationships Subject–Predicate–Object triples

TTTA extracted 116 structured relationships around Cyclin-dependent kinase 4. Examples in this analysis include Cyclin-dependent kinase 4 → 2.7.11.22 → ↗ and Cyclin-dependent kinase 4 → Aliases → CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Cyclin-dependent kinase 4	2.7.11.22	↗	1.00	infobox
Cyclin-dependent kinase 4	Aliases	CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4	1.00	infobox
Cyclin-dependent kinase 4	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK	1.00	infobox
Cyclin-dependent kinase 4	Band	12q14.1	1.00	infobox
Cyclin-dependent kinase 4	Bgee	ganglionic eminence	1.00	infobox
Cyclin-dependent kinase 4	Bgee	ventricular zone	1.00	infobox
Cyclin-dependent kinase 4	Bgee	stromal cell of endometrium	1.00	infobox
Cyclin-dependent kinase 4	Bgee	right adrenal gland	1.00	infobox
Cyclin-dependent kinase 4	Bgee	right ovary	1.00	infobox
Cyclin-dependent kinase 4	Bgee	smooth muscle tissue	1.00	infobox
Cyclin-dependent kinase 4	Bgee	right adrenal cortex	1.00	infobox
Cyclin-dependent kinase 4	Bgee	left ovary	1.00	infobox
Cyclin-dependent kinase 4	Bgee	left adrenal gland	1.00	infobox
Cyclin-dependent kinase 4	Bgee	left adrenal cortex	1.00	infobox
Cyclin-dependent kinase 4	BioGPS	More reference expression data	1.00	infobox
Cyclin-dependent kinase 4	Chr.	Chromosome 12 (human)	1.00	infobox
Cyclin-dependent kinase 4	Databases	NCBI: entry; OMA: entry	1.00	infobox
Cyclin-dependent kinase 4	End	57,756,013 bp	1.00	infobox
Cyclin-dependent kinase 4	Ensembl	ENSG00000135446	1.00	infobox
Cyclin-dependent kinase 4	Entrez	1019	1.00	infobox
Cyclin-dependent kinase 4	Enzyme activity	Enzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.11.22↗↗↗↗	1.00	infobox
Cyclin-dependent kinase 4	External IDs	OMIM: 123829; MGI: 88357; GeneCards: CDK4	1.00	infobox
Cyclin-dependent kinase 4	Gene location (Human)	Gene location (Human)Chr.Chromosome 12 (human)Band12q14.1Start57,747,727 bpEnd57,756,013 bp	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	transferase activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	nucleotide binding	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	protein kinase activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	kinase activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	protein serine/threonine kinase activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	cyclin-dependent protein serine/threonine kinase regulator activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	protein binding	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Cyclin-dependent kinase 4 bring nearby vocabulary together. In this analysis, examples include Kinase, Bp and Chromosome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Cyclin-dependent kinase 4
- Kinase
- Bp
- Chromosome
- Serine
- Threonine
- Gene
- Human
- Regulation
- Activity
- Site
- Protein
- Cell
cyclin-dependent kinase 4
- Kinase
- Bp
- Chromosome
- Serine
- Threonine
- Cyclin
- Activity
- Gene
- Human
- Regulation
- Atp
- Site
cyclin-dependent kinase
- Kinase
- Bp
- Chromosome
- Serine
- Threonine
- Cyclin
- Activity
- Gene
- Human
- Regulation
- Atp
- Site
cell cycle
- Cycle
- Complex
- G1
- Regulate
- Regulation
- Role
- Protein
- Factors
- Serine
- Threonine
- Kinase
- Cyclin-dependent
g1/s transition
- G1
- Transition
- Rb
- Phase
- Protein
- Complex
- Cyclin
- Phosphorylation
- Regulate
- Activity
- Regulation
- Progression
cyclin d
- Activity
- Inhibitors
- Kinase
- Transition
- G1
- Binding
- Regulation
- Active
- Cdk
- Phase
- Protein
- Bp
cyclin kinase inhibitors
- Activity
- Serine
- Threonine
- Inhibitors
- Cyclin
- Kinase
- Transition
- G1
- Gene
- Regulation
- Atp
- Binding
retinoblastoma (rb) protein family including rb1
- Progression
- Protein
- Rb
- E2f
- Regulate
- Transition
- Proteins
- Inhibitors
- Like
- Regulation
- Complex
- Cyclin

Connections between topic areas Semantic bridges

For Cyclin-dependent kinase 4, one of the stronger structural bridges in this analysis connects Cyclin-dependent kinase 4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Cyclin-dependent kinase 4 — Overview · splits 24 ⟂ 14

Cyclin-dependent kinase 4 — Interactions · splits 24 ⟂ 14

Cyclin-dependent kinase 4 — Clinical significance · splits 33 ⟂ 5

Cyclin-dependent kinase 4 — Function · splits 34 ⟂ 4

Map overview Semantic statistics

Cyclin-dependent kinase 4

Nodes38

Edges37

Triples116

Avg. degree1.95

Density0.052632

Components1

Source & methodology

TTTA analyzes the structure around Cyclin-dependent kinase 4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Cyclin-dependent kinase 4 · EN edition · Analysis: TopicsToTalkAbout