Proto-oncogene tyrosine-protein kinase Src

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Interactions

PI3K Akt IKK NFkB Caspase 9

25 related topics

Structure

Yes Fyn Fgr Yrk Lyn

19 related topics

Overview

Sarcoma Non-receptor tyrosine kinase Gene Src family kinases V-Src

19 related topics

As a drug target

Dasatinib Chronic myeloid leukemia Bosutinib Bafetinib Saracatinib

5 related topics

Key facts & relationships

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2.7.10.2: ↗
Aliases: SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47,…
Band: 20q11.23 · 2 H1|2 78.35 cM
Bgee: body of stomach · gallbladder · rectum · body of pancreas · transverse colon
BioGPS: More reference expression data

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Overview

Discovery

Mutated Mutation

Structure

Yes YES1
Fyn
Fgr FGR (gene)
Yrk YRK (gene)?action=edit&redlink=1
Lyn
Blk Tyrosine-protein kinase BLK
Hck
Lck
Flexible linker
Allostery
Protein domain dynamics Protein dynamics
Adhesion receptors Adhesion receptor
Receptor tyrosine kinases Receptor tyrosine kinase
G-protein coupled receptors
Cytokine receptors Cytokine receptor
Platelet derived growth factor receptor
Epidermal growth factor receptor
Flexible protein domains Protein domain
Myristoylation

Function

Angiogenesis
Proliferation Cell growth

As a drug target

Interactions

PI3K
Akt
IKK IκB kinase
NFkB
Caspase 9
STAT3
P38 MAPK P38 mitogen-activated protein kinases
VEGF
IL-8 Interleukin 8
Shc Src homology 2 domain-containing
Grb2
Ras Ras subfamily
Raf Raf kinase
MEK1 MAP2K1
MEK2
Erk1/2 Extracellular signal-regulated kinases
FAK PTK2
P190Rho/GAP CNTNAP1
Paxillin
P130CAS BCAR1
RhoA
JNK
C-jun
MLCK
Myosin

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Map overview Semantic statistics

Proto-oncogene tyrosine-protein kinase Src

Nodes78

Edges77

Triples266

Avg. degree1.97

Density0.025641

Components1

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Proto-oncogene tyrosine-protein kinase Src

Top relations

Gene ontology · 184

Proto-oncogene tyrosine-protein kinase Src → actin filament, activation of protein kinase B activity, adherens junction organization, angiotensin-activated signaling pathway involved in heart process, ATP binding, axon guidance, bone resorption, branching involved in mammary gland duct morphogenesis, cadherin binding, caveola, cell adhesion, cell adhesion molecule binding, cell cycle, cell differentiation, cell migration, cell population proliferation, cell-cell adhesion, cellular response to fatty acid, cellular response to fluid shear stress, cellular response to hydrogen peroxide

Bgee · 20

Proto-oncogene tyrosine-protein kinase Src → aortic valve, ascending aorta, body of pancreas, body of stomach, body of uterus, dentate gyrus of hippocampal formation granule cell, ectocervix, external carotid artery, gallbladder, ganglionic eminence, internal carotid artery, jejunum, molar, mucosa of transverse colon, muscle layer of sigmoid colon, primary visual cortex, rectum, superior frontal gyrus, transverse colon, ventricular zone

RNA expression pattern · 20

related to External links · 17

Proto-oncogene tyrosine-protein kinase Src → Cell Migration Gateway Archived, Family, Gene, Info, Kinases, Medicine Medical Subject Headings, MeSH, National Library, P12931, PDB, PDBe-KB, Proteopedia SRC, Proto-oncogene, Src, SRCVega, UniProt, Wayback MachineOverview

Band · 2

Proto-oncogene tyrosine-protein kinase Src → 2 H1|2 78.35 cM, 20q11.23

Chr. · 2

Proto-oncogene tyrosine-protein kinase Src → Chromosome 2 (mouse), Chromosome 20 (human)

End · 2

Proto-oncogene tyrosine-protein kinase Src → 157,471,862 bp, 37,406,050 bp

2.7.10.2 · 1

Proto-oncogene tyrosine-protein kinase Src → ↗

Aliases · 1

Proto-oncogene tyrosine-protein kinase Src → SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6

Available structures · 1

Proto-oncogene tyrosine-protein kinase Src → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47,…

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

c-src src tyrosine gene kinase cancer activity kinases human bp cell growth protein chr band colon also proliferation breast sh2

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	↗	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Aliases	SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47,…	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Band	20q11.23	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Band	2 H1\|2 78.35 cM	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	body of stomach	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	gallbladder	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	rectum	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	body of pancreas	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	transverse colon	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	ganglionic eminence	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	ectocervix	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	body of uterus	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	muscle layer of sigmoid colon	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	mucosa of transverse colon	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	dentate gyrus of hippocampal formation granule cell	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	external carotid artery	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	superior frontal gyrus	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	primary visual cortex	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	internal carotid artery	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	ventricular zone	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	molar	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	aortic valve	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	ascending aorta	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Bgee	jejunum	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	BioGPS	More reference expression data	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Chr.	Chromosome 20 (human)	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Chr.	Chromosome 2 (mouse)	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	Databases	NCBI: entry; OMA: entry	1.00	infobox
Proto-oncogene tyrosine-protein kinase Src	End	37,406,050 bp	1.00	infobox

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