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Tyrosine-protein kinase CSK: Role in development and regulation, Function & Mutations

Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1.

Language: English [EN]
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Tyrosine-protein kinase CSK topic overview

The analysis highlights Role in development and regulation, Function and Mutations as prominent areas in the source structure around Tyrosine-protein kinase CSK.

Related topics
38
Source areas
5
Connected nodes
43
Extracted relationships
120
Concept neighborhoods
20
Bridge connections
43

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Role in development and regulation · 15 topics
Overview · 11 topics
Function · 8 topics
Clinical significance · 2 topics
Mutations · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.4
Aliases
CSK, Src, c-src tyrosine kinase, CSK/Src, non-receptor tyrosine kinase, C-terminal Src kinase
Available structures
Available structuresPDBOrtholog search: H3BU69 PDBe H3BU69 RCSB List of PDB id codes1BYG, 1CSK, 3D7T, 3D7U, 3EAC, 3EAZ
Band
15q24.1 · 9 B|9 31.18 cM
Bgee
granulocyte · monocyte · spleen · blood · lymph node
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Role in development and regulation

Mutations

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Tyrosine-protein kinase CSK connects Entity context

The extracted context around Tyrosine-protein kinase CSK shows recurring relationship patterns in the source. For example, Tyrosine-protein kinase CSK → adaptive immune response, adherens junction organization, ATP binding, brain development, cell differentiation, cell-cell junction, cellular response to peptide hormone stimulus, central nervous system development, cytoplasm, cytosol, epidermal growth factor receptor signaling pathway, extracellular exosome, extrinsic component of cytoplasmic side of plasma membrane, identical protein binding, immune system process, innate immune response, kinase activity, membrane, membrane raft, metal ion binding Another extracted example is Tyrosine-protein kinase CSK → appendix, blood, bone marrow cell, gastrula, granulocyte, lip, lymph node, mesenteric lymph nodes, monocyte, mucosa of transverse colon, neural layer of retina, spleen, stromal cell of endometrium, thymus, tonsil, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

Tyrosine-protein kinase CSK

Top relations

Gene ontology · 53
Tyrosine-protein kinase CSK → adaptive immune response, adherens junction organization, ATP binding, brain development, cell differentiation, cell-cell junction, cellular response to peptide hormone stimulus, central nervous system development, cytoplasm, cytosol, epidermal growth factor receptor signaling pathway, extracellular exosome, extrinsic component of cytoplasmic side of plasma membrane, identical protein binding, immune system process, innate immune response, kinase activity, membrane, membrane raft, metal ion binding
Bgee · 17
Tyrosine-protein kinase CSK → appendix, blood, bone marrow cell, gastrula, granulocyte, lip, lymph node, mesenteric lymph nodes, monocyte, mucosa of transverse colon, neural layer of retina, spleen, stromal cell of endometrium, thymus, tonsil, ventricular zone, yolk sac
RNA expression pattern · 17
Tyrosine-protein kinase CSK → appendix, blood, bone marrow cell, gastrula, granulocyte, lip, lymph node, mesenteric lymph nodes, monocyte, mucosa of transverse colon, neural layer of retina, spleen, stromal cell of endometrium, thymus, tonsil, ventricular zone, yolk sac
related to Role in development and regulation · 8
Tyrosine-protein kinase CSK → Adherens, CSK, ERK1, ERK2, Fc, Golgi, MAP, Tyrosine-protein
Band · 2
Tyrosine-protein kinase CSK → 15q24.1, 9 B|9 31.18 cM
Chr. · 2
Tyrosine-protein kinase CSK → Chromosome 15 (human), Chromosome 9 (mouse)
End · 2
Tyrosine-protein kinase CSK → 57,560,914 bp, 74,803,198 bp
2.7.10.4 · 1
Tyrosine-protein kinase CSK → ↗
Aliases · 1
Tyrosine-protein kinase CSK → CSK, Src, c-src tyrosine kinase, CSK/Src, non-receptor tyrosine kinase, C-terminal Src kinase
Available structures · 1
Tyrosine-protein kinase CSK → Available structuresPDBOrtholog search: H3BU69 PDBe H3BU69 RCSB List of PDB id codes1BYG, 1CSK, 3D7T, 3D7U, 3EAC, 3EAZ

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

csk kinase bp gene chr human band c-terminal src phosphorylation location enzyme activity chromosome 15 tyrosine regulation tyrosine-protein end kinases

Tyrosine-protein kinase CSK relationships Subject–Predicate–Object triples

TTTA extracted 120 structured relationships around Tyrosine-protein kinase CSK. Examples in this analysis include Tyrosine-protein kinase CSK → 2.7.10.4 → ↗ and Tyrosine-protein kinase CSK → Aliases → CSK, Src, c-src tyrosine kinase, CSK/Src, non-receptor tyrosine kinase, C-terminal Src kinase. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Tyrosine-protein kinase CSK2.7.10.41.00infobox
Tyrosine-protein kinase CSKAliasesCSK, Src, c-src tyrosine kinase, CSK/Src, non-receptor tyrosine kinase, C-terminal Src kinase1.00infobox
Tyrosine-protein kinase CSKAvailable structuresAvailable structuresPDBOrtholog search: H3BU69 PDBe H3BU69 RCSB List of PDB id codes1BYG, 1CSK, 3D7T, 3D7U, 3EAC, 3EAZ1.00infobox
Tyrosine-protein kinase CSKBand15q24.11.00infobox
Tyrosine-protein kinase CSKBand9 B|9 31.18 cM1.00infobox
Tyrosine-protein kinase CSKBgeegranulocyte1.00infobox
Tyrosine-protein kinase CSKBgeemonocyte1.00infobox
Tyrosine-protein kinase CSKBgeespleen1.00infobox
Tyrosine-protein kinase CSKBgeeblood1.00infobox
Tyrosine-protein kinase CSKBgeelymph node1.00infobox
Tyrosine-protein kinase CSKBgeeappendix1.00infobox
Tyrosine-protein kinase CSKBgeemucosa of transverse colon1.00infobox
Tyrosine-protein kinase CSKBgeetonsil1.00infobox
Tyrosine-protein kinase CSKBgeebone marrow cell1.00infobox
Tyrosine-protein kinase CSKBgeestromal cell of endometrium1.00infobox
Tyrosine-protein kinase CSKBgeemesenteric lymph nodes1.00infobox
Tyrosine-protein kinase CSKBgeethymus1.00infobox
Tyrosine-protein kinase CSKBgeeneural layer of retina1.00infobox
Tyrosine-protein kinase CSKBgeelip1.00infobox
Tyrosine-protein kinase CSKBgeeventricular zone1.00infobox
Tyrosine-protein kinase CSKBgeeyolk sac1.00infobox
Tyrosine-protein kinase CSKBgeegastrula1.00infobox
Tyrosine-protein kinase CSKBioGPSMore reference expression data1.00infobox
Tyrosine-protein kinase CSKChr.Chromosome 15 (human)1.00infobox
Tyrosine-protein kinase CSKChr.Chromosome 9 (mouse)1.00infobox
Tyrosine-protein kinase CSKDatabasesNCBI: entry; OMA: entry1.00infobox
Tyrosine-protein kinase CSKEnd74,803,198 bp1.00infobox
Tyrosine-protein kinase CSKEnd57,560,914 bp1.00infobox
Tyrosine-protein kinase CSKEnsemblENSG000001036531.00infobox
Tyrosine-protein kinase CSKEntrez14451.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Tyrosine-protein kinase CSK bring nearby vocabulary together. In this analysis, examples include Kinase, Tyrosine-protein and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Tyrosine-protein kinase CSK
    • Kinase
    • Tyrosine-protein
    • Cell
    • Differentiation
    • Growth
    • Immune
    • Response
    • Csk
    • Development
    • Junction
    • Membrane
    • Plasma
  • tyrosine-protein kinase csk
    • Kinase
    • Tyrosine-protein
    • Cell
    • Csk
    • Development
    • Differentiation
    • Growth
    • Immune
    • Regulation
    • Response
    • Protein
    • Activity
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Expression
    • Function
    • Mouse
    • Kinase
    • Development
    • End
    • Regulation
  • c-terminal
    • Src
    • Enzyme
    • Kinases
    • Tyrosine
    • Csk
    • Activity
    • Gene
    • External
    • Kinase
    • Expression
    • Function
    • Located
  • cell growth
    • Differentiation
    • Growth
    • Immune
    • Response
    • Development
    • Junction
    • Membrane
    • Plasma
    • Receptor
    • Regulation
    • Signaling
    • Protein
  • map kinase
    • Tyrosine-protein
    • Csk
    • Development
    • Regulation
    • Protein
    • Activity
    • Gene
    • Cell
    • Differentiation
    • Expression
    • Function
    • Growth
  • t cell
    • Differentiation
    • Growth
    • Immune
    • Response
    • Development
    • Junction
    • Membrane
    • Plasma
    • Receptor
    • Regulation
    • Signaling
    • Protein
  • t cell receptor
    • Differentiation
    • Growth
    • Immune
    • Response
    • Signaling
    • Development
    • Junction
    • Membrane
    • Plasma
    • Receptor
    • Regulation
    • Protein

Connections between topic areas Semantic bridges

For Tyrosine-protein kinase CSK, one of the stronger structural bridges in this analysis connects Tyrosine-protein kinase CSK with Role in development and regulation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Tyrosine-protein kinase CSKRole in development and regulation · splits 28 ⟂ 16
Tyrosine-protein kinase CSKOverview · splits 32 ⟂ 12
Tyrosine-protein kinase CSKFunction · splits 35 ⟂ 9
Tyrosine-protein kinase CSKMutations · splits 41 ⟂ 3
Tyrosine-protein kinase CSKClinical significance · splits 41 ⟂ 3

Map overview Semantic statistics

Tyrosine-protein kinase CSK

Nodes44
Edges43
Triples120
Avg. degree1.95
Density0.045455
Components1

Source & methodology

TTTA analyzes the structure around Tyrosine-protein kinase CSK to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in development and regulation, Function & Mutations, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tyrosine-protein kinase CSK · EN edition · Analysis: TopicsToTalkAbout

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