Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

PLK1

Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene.

Regions, Cell cycle regulation & Role in tumorigenesis

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around PLK1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Cell cycle regulation

18 related topics

Role in tumorigenesis

17 related topics

Interactions

10 related topics

Clinical significance

9 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.21
Aliases
PLK1, PLK, STPK13, polo like kinase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Q4K, 1Q4O, 1UMW, 2OJX, 2OU7, 2OWB, 2RKU, 2V5Q, 2YAC, 3BZI, 3C5L, 3FVH, 3HIH, 3HIK, 3KB7, 3P2W, 3P2Z, 3P34,…
Band
16p12.2 · 7 F2|7 65.52 cM
Bgee
ventricular zone · gonad · ganglionic eminence · mucosa of transverse colon · left testis
BioGPS
More reference expression data

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Structure

Localization

Cell cycle regulation

Role in tumorigenesis

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

PLK1

Nodes76
Edges75
Triples193
Avg. degree1.97
Density0.026316
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

PLK1

Top relations

Gene ontology · 81
PLK1 → anaphase-promoting complex binding, anaphase-promoting complex-dependent catabolic process, ATP binding, cell cycle, cell division, cell population proliferation, centriolar satellite, centriole, centrosome, centrosome cycle, chromatin, chromosome, chromosome, centromeric region, ciliary basal body-plasma membrane docking, cytoplasm, cytoskeleton, cytosol, establishment of mitotic spindle orientation, establishment of protein localization, female meiosis chromosome segregation
Bgee · 19
PLK1 → abdominal wall, epiblast, ganglionic eminence, gonad, left testis, mucosa of transverse colon, otic placode, otic vesicle, primitive streak, rectum, right testis, secondary oocyte, spermatid, stromal cell of endometrium, tail of embryo, testicle, ventricular zone, yolk sac, zygote
RNA expression pattern · 19
PLK1 → abdominal wall, epiblast, ganglionic eminence, gonad, left testis, mucosa of transverse colon, otic placode, otic vesicle, primitive streak, rectum, right testis, secondary oocyte, spermatid, stromal cell of endometrium, tail of embryo, testicle, ventricular zone, yolk sac, zygote
related to Cell cycle regulation · 16
PLK1 → Abnormal, APC, Asp, CHO1/MKLP1, Drosophila, E3, Fizzy-Cdc20, G2/early, G2/M, M-phase, PAR, Plk, Polo, Studies, The, The APC
related to Interactions · 9
PLK1 → CHEK2, NUDC, PIN1, PSMA3, PSMA5, PSMA6, PSMA7, PSMB3, Vimentin
related to Role in tumorigenesis · 7
PLK1 → Abnormal, Aneuploidy, Centrosome, NIH3T3, Oncogenic, Supporting, These
related to Clinical significance · 5
PLK1 → K-RAS, Many, RNA, These, When PLK1
related to Meiosis · 4
PLK1 → Based, CDC5, In CDC5, Mam1
related to Structure · 4
PLK1 → C-terminus, In, Kinase, N-terminus
related to Localization · 3
PLK1 → During, GFP-PLK1, In

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kinase chromosome centrosome cell bp gene human also chr band meiosis protein tumor 16 spindle segregation overexpression cycle cells mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PLK12.7.11.211.00infobox
PLK1AliasesPLK1, PLK, STPK13, polo like kinase 11.00infobox
PLK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Q4K, 1Q4O, 1UMW, 2OJX, 2OU7, 2OWB, 2RKU, 2V5Q, 2YAC, 3BZI, 3C5L, 3FVH, 3HIH, 3HIK, 3KB7, 3P2W, 3P2Z, 3P34,…1.00infobox
PLK1Band16p12.21.00infobox
PLK1Band7 F2|7 65.52 cM1.00infobox
PLK1Bgeeventricular zone1.00infobox
PLK1Bgeegonad1.00infobox
PLK1Bgeeganglionic eminence1.00infobox
PLK1Bgeemucosa of transverse colon1.00infobox
PLK1Bgeeleft testis1.00infobox
PLK1Bgeeright testis1.00infobox
PLK1Bgeestromal cell of endometrium1.00infobox
PLK1Bgeerectum1.00infobox
PLK1Bgeetesticle1.00infobox
PLK1Bgeesecondary oocyte1.00infobox
PLK1Bgeetail of embryo1.00infobox
PLK1Bgeeepiblast1.00infobox
PLK1Bgeeotic vesicle1.00infobox
PLK1Bgeezygote1.00infobox
PLK1Bgeeotic placode1.00infobox
PLK1Bgeespermatid1.00infobox
PLK1Bgeeyolk sac1.00infobox
PLK1Bgeeabdominal wall1.00infobox
PLK1Bgeeprimitive streak1.00infobox
PLK1BioGPSMore reference expression data1.00infobox
PLK1Chr.Chromosome 16 (human)1.00infobox
PLK1Chr.Chromosome 7 (mouse)1.00infobox
PLK1DatabasesNCBI: entry; OMA: entry1.00infobox
PLK1End23,690,367 bp1.00infobox
PLK1End121,769,096 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.