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Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene.
The analysis highlights Regions, Cell cycle regulation and Role in tumorigenesis as prominent areas in the source structure around PLK1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around PLK1 shows recurring relationship patterns in the source. For example, PLK1 → anaphase-promoting complex binding, anaphase-promoting complex-dependent catabolic process, ATP binding, cell cycle, cell division, cell population proliferation, centriolar satellite, centriole, centrosome, centrosome cycle, chromatin, chromosome, chromosome, centromeric region, ciliary basal body-plasma membrane docking, cytoplasm, cytoskeleton, cytosol, establishment of mitotic spindle orientation, establishment of protein localization, female meiosis chromosome segregation Another extracted example is PLK1 → abdominal wall, epiblast, ganglionic eminence, gonad, left testis, mucosa of transverse colon, otic placode, otic vesicle, primitive streak, rectum, right testis, secondary oocyte, spermatid, stromal cell of endometrium, tail of embryo, testicle, ventricular zone, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
kinase chromosome centrosome cell bp gene human also chr band meiosis protein tumor 16 spindle segregation overexpression cycle cells mouse
TTTA extracted 193 structured relationships around PLK1. Examples in this analysis include PLK1 → 2.7.11.21 → ↗ and PLK1 → Aliases → PLK1, PLK, STPK13, polo like kinase 1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| PLK1 | 2.7.11.21 | ↗ | 1.00 | infobox |
| PLK1 | Aliases | PLK1, PLK, STPK13, polo like kinase 1 | 1.00 | infobox |
| PLK1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Q4K, 1Q4O, 1UMW, 2OJX, 2OU7, 2OWB, 2RKU, 2V5Q, 2YAC, 3BZI, 3C5L, 3FVH, 3HIH, 3HIK, 3KB7, 3P2W, 3P2Z, 3P34,… | 1.00 | infobox |
| PLK1 | Band | 16p12.2 | 1.00 | infobox |
| PLK1 | Band | 7 F2|7 65.52 cM | 1.00 | infobox |
| PLK1 | Bgee | ventricular zone | 1.00 | infobox |
| PLK1 | Bgee | gonad | 1.00 | infobox |
| PLK1 | Bgee | ganglionic eminence | 1.00 | infobox |
| PLK1 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| PLK1 | Bgee | left testis | 1.00 | infobox |
| PLK1 | Bgee | right testis | 1.00 | infobox |
| PLK1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| PLK1 | Bgee | rectum | 1.00 | infobox |
| PLK1 | Bgee | testicle | 1.00 | infobox |
| PLK1 | Bgee | secondary oocyte | 1.00 | infobox |
| PLK1 | Bgee | tail of embryo | 1.00 | infobox |
| PLK1 | Bgee | epiblast | 1.00 | infobox |
| PLK1 | Bgee | otic vesicle | 1.00 | infobox |
| PLK1 | Bgee | zygote | 1.00 | infobox |
| PLK1 | Bgee | otic placode | 1.00 | infobox |
| PLK1 | Bgee | spermatid | 1.00 | infobox |
| PLK1 | Bgee | yolk sac | 1.00 | infobox |
| PLK1 | Bgee | abdominal wall | 1.00 | infobox |
| PLK1 | Bgee | primitive streak | 1.00 | infobox |
| PLK1 | BioGPS | More reference expression data | 1.00 | infobox |
| PLK1 | Chr. | Chromosome 16 (human) | 1.00 | infobox |
| PLK1 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| PLK1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| PLK1 | End | 23,690,367 bp | 1.00 | infobox |
| PLK1 | End | 121,769,096 bp | 1.00 | infobox |
The concept neighborhoods around PLK1 bring nearby vocabulary together. In this analysis, examples include Cell, Tumor and Also. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For PLK1, one of the stronger structural bridges in this analysis connects PLK1 with Cell cycle regulation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around PLK1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Cell cycle regulation & Role in tumorigenesis, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — PLK1 · EN edition · Analysis: TopicsToTalkAbout