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BUB1B: Interactions, Function & DNA repair

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. Also known as BubR1, this protein is recognized for its mitotic roles in the spindle assembly checkpoint (SAC) and kinetochore-microtubule interactions that facilitate chromosome migration and alignment. BubR1 promotes mitotic fidelity…

Language: English [EN]
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BUB1B topic overview

The analysis highlights Interactions, Function and DNA repair as prominent areas in the source structure around BUB1B.

Related topics
31
Source areas
5
Connected nodes
36
Extracted relationships
114
Related term clusters
14
Bridge connections
36

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 14 topics
Function · 8 topics
DNA repair · 4 topics
Clinical Significance · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1
↗
Aliases
BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WVI, 3SI5, 4GGD, 5JJA
Band
15q15.1 · 2|2 E5
Bgee
secondary oocyte · ventricular zone · gonad · embryo · Epithelium of choroid plexus
BioGPS
More reference expression data

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical Significance

DNA repair

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How BUB1B connects Entity context

The extracted context around BUB1B shows recurring relationship patterns in the source. For example, BUB1B → anaphase-promoting complex, anaphase-promoting complex-dependent catabolic process, apoptotic process, ATP binding, cell cycle, cell division, cell population proliferation, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinase activity, kinetochore, meiotic sister chromatid cohesion, centromeric, metaphase, microtubule organizing center, mitotic cell cycle, mitotic cell cycle checkpoint signaling, mitotic spindle assembly checkpoint signaling Another extracted example is BUB1B → bone marrow, ectoderm, embryo, Epithelium of choroid plexus, ganglionic eminence, genital tubercle, gonad, left testis, otic placode, otic vesicle, primary oocyte, primitive streak, right testis, secondary oocyte, spermatocyte, tail of embryo, trabecular bone, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

BUB1B

Top relations

Gene ontology · 36
BUB1B → anaphase-promoting complex, anaphase-promoting complex-dependent catabolic process, apoptotic process, ATP binding, cell cycle, cell division, cell population proliferation, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinase activity, kinetochore, meiotic sister chromatid cohesion, centromeric, metaphase, microtubule organizing center, mitotic cell cycle, mitotic cell cycle checkpoint signaling, mitotic spindle assembly checkpoint signaling
Bgee · 19
BUB1B → bone marrow, ectoderm, embryo, Epithelium of choroid plexus, ganglionic eminence, genital tubercle, gonad, left testis, otic placode, otic vesicle, primary oocyte, primitive streak, right testis, secondary oocyte, spermatocyte, tail of embryo, trabecular bone, ventricular zone, zygote
RNA expression pattern · 19
BUB1B → bone marrow, ectoderm, embryo, Epithelium of choroid plexus, ganglionic eminence, genital tubercle, gonad, left testis, otic placode, otic vesicle, primary oocyte, primitive streak, right testis, secondary oocyte, spermatocyte, tail of embryo, trabecular bone, ventricular zone, zygote
related to DNA repair · 6
BUB1B → A-NHEJ, Bladder, Chemoradiotherapy, CRT, CRT-recurrent, DNA
Band · 2
BUB1B → 15q15.1, 2|2 E5
Chr. · 2
BUB1B → Chromosome 15 (human), Chromosome 2 (mouse)
End · 2
BUB1B → 118,472,072 bp, 40,221,123 bp
related to Interactions · 2
BUB1B → AP2B1BRCA2BUB3CDC20MAD2L1CBPSIRT2PLK1PP2A-B56HDAC1HDAC2, HDAC3SNCG
2.7.11.1 · 1
BUB1B → ↗
Aliases · 1
BUB1B → BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

chromosome bubr1 checkpoint mitotic bp gene human chr band kinase 15 spindle protein location function cancer crt serine expression segregation

BUB1B relationships Subject–Predicate–Object triples

TTTA extracted 114 structured relationships around BUB1B. Examples in this analysis include BUB1B → 2.7.11.1 → ↗ and BUB1B → Aliases → BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
BUB1B2.7.11.1↗1.00infobox
BUB1BAliasesBUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B1.00infobox
BUB1BAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WVI, 3SI5, 4GGD, 5JJA1.00infobox
BUB1BBand15q15.11.00infobox
BUB1BBand2|2 E51.00infobox
BUB1BBgeesecondary oocyte1.00infobox
BUB1BBgeeventricular zone1.00infobox
BUB1BBgeegonad1.00infobox
BUB1BBgeeembryo1.00infobox
BUB1BBgeeEpithelium of choroid plexus1.00infobox
BUB1BBgeeganglionic eminence1.00infobox
BUB1BBgeeright testis1.00infobox
BUB1BBgeebone marrow1.00infobox
BUB1BBgeeleft testis1.00infobox
BUB1BBgeetrabecular bone1.00infobox
BUB1BBgeeprimary oocyte1.00infobox
BUB1BBgeeectoderm1.00infobox
BUB1BBgeeotic vesicle1.00infobox
BUB1BBgeeprimitive streak1.00infobox
BUB1BBgeeotic placode1.00infobox
BUB1BBgeetail of embryo1.00infobox
BUB1BBgeespermatocyte1.00infobox
BUB1BBgeegenital tubercle1.00infobox
BUB1BBgeezygote1.00infobox
BUB1BBioGPSMore reference expression data1.00infobox
BUB1BChr.Chromosome 15 (human)1.00infobox
BUB1BChr.Chromosome 2 (mouse)1.00infobox
BUB1BDatabasesNCBI: entry; OMA: entry1.00infobox
BUB1BEnd40,221,123 bp1.00infobox
BUB1BEnd118,472,072 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around BUB1B bring nearby vocabulary together. In this analysis, examples include Gene, Kinase and Serine. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • BUB1B
    • Gene
    • Kinase
    • Serine
    • Location
    • Checkpoint
    • Human
    • Mitotic
    • Activity
    • Enzyme
    • Search
    • Threonine
    • Function
  • bub1b
    • Gene
    • Kinase
    • Serine
    • Location
    • Checkpoint
    • Human
    • Mitotic
    • Activity
    • Enzyme
    • Search
    • Threonine
    • Function
  • gene
    • Location
    • Human
    • Kinase
    • Serine
    • Bp
    • Chr
    • Mitotic
    • Activity
    • Mouse
    • Search
    • Threonine
    • Chromosome
  • kinase
    • Serine
    • Activity
    • Bub1
    • Enzyme
    • Search
    • Threonine
    • Bub1b
    • Gene
    • Mitotic
    • Function
    • Location
    • Bp
  • spindle checkpoint
    • Mitotic
    • Function
    • Kinase
    • Serine
    • Spindle
    • Bub1b
    • Gene
    • Activity
    • Assembly
    • Bub1
    • Enzyme
    • Interactions
  • chromosome segregation
    • Bp
    • Chr
    • Human
    • Mitotic
    • Segregation
    • Band
    • Location
    • Protein
    • Gene
    • Activity
    • Ensuring
    • Interactions
  • chromosome
    • Bp
    • Chr
    • Human
    • Mitotic
    • Segregation
    • Band
    • Location
    • Protein
    • Gene
    • Activity
    • Ensuring
    • Interactions
  • function
    • Activity
    • Search
    • Threonine
    • Kinase
    • Serine
    • Spindle
    • Location
    • Bp
    • Chr
    • External
    • Gene
    • Human

Connections between topic areas Semantic bridges

For BUB1B, one of the stronger structural bridges in this analysis connects BUB1B with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
BUB1B — Interactions · splits 22 ⟂ 15
BUB1B — Function · splits 28 ⟂ 9
BUB1B — DNA repair · splits 32 ⟂ 5
BUB1B — Clinical Significance · splits 33 ⟂ 4
BUB1B — Overview · splits 34 ⟂ 3

Map overview Semantic statistics

BUB1B

Nodes37
Edges36
Triples114
Avg. degree1.95
Density0.054054
Components1

Source & methodology

TTTA analyzes the structure around BUB1B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & DNA repair, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — BUB1B · EN edition · Analysis: TopicsToTalkAbout

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