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BUB1B

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. Also known as BubR1, this protein is recognized for its mitotic roles in the spindle assembly checkpoint (SAC) and kinetochore-microtubule interactions that facilitate chromosome migration and alignment. BubR1 promotes mitotic fidelity…

Interactions, Function & DNA repair

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2.7.11.1
↗
Aliases
BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WVI, 3SI5, 4GGD, 5JJA
Band
15q15.1 · 2|2 E5
Bgee
secondary oocyte · ventricular zone · gonad · embryo · Epithelium of choroid plexus
BioGPS
More reference expression data

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Function

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DNA repair

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BUB1B

Nodes37
Edges36
Triples118
Avg. degree1.95
Density0.054054
Components1

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BUB1B

Top relations

Gene ontology · 36
BUB1B → anaphase-promoting complex, anaphase-promoting complex-dependent catabolic process, apoptotic process, ATP binding, cell cycle, cell division, cell population proliferation, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinase activity, kinetochore, meiotic sister chromatid cohesion, centromeric, metaphase, microtubule organizing center, mitotic cell cycle, mitotic cell cycle checkpoint signaling, mitotic spindle assembly checkpoint signaling
Bgee · 19
BUB1B → bone marrow, ectoderm, embryo, Epithelium of choroid plexus, ganglionic eminence, genital tubercle, gonad, left testis, otic placode, otic vesicle, primary oocyte, primitive streak, right testis, secondary oocyte, spermatocyte, tail of embryo, trabecular bone, ventricular zone, zygote
RNA expression pattern · 19
BUB1B → bone marrow, ectoderm, embryo, Epithelium of choroid plexus, ganglionic eminence, genital tubercle, gonad, left testis, otic placode, otic vesicle, primary oocyte, primitive streak, right testis, secondary oocyte, spermatocyte, tail of embryo, trabecular bone, ventricular zone, zygote
related to DNA repair · 8
BUB1B → A-NHEJ, An, Bladder, Chemoradiotherapy, CRT, CRT-recurrent, DNA, This
Band · 2
BUB1B → 15q15.1, 2|2 E5
Chr. · 2
BUB1B → Chromosome 15 (human), Chromosome 2 (mouse)
End · 2
BUB1B → 118,472,072 bp, 40,221,123 bp
related to External links · 2
BUB1B → Human BUB1B, UCSC Genome Browser
related to Interactions · 2
BUB1B → AP2B1BRCA2BUB3CDC20MAD2L1CBPSIRT2PLK1PP2A-B56HDAC1HDAC2, HDAC3SNCG
2.7.11.1 · 1
BUB1B → ↗

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Important terminology

chromosome bubr1 checkpoint mitotic bp gene human chr band kinase 15 spindle protein location function cancer crt serine expression segregation

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BUB1B2.7.11.1↗1.00infobox
BUB1BAliasesBUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B1.00infobox
BUB1BAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WVI, 3SI5, 4GGD, 5JJA1.00infobox
BUB1BBand15q15.11.00infobox
BUB1BBand2|2 E51.00infobox
BUB1BBgeesecondary oocyte1.00infobox
BUB1BBgeeventricular zone1.00infobox
BUB1BBgeegonad1.00infobox
BUB1BBgeeembryo1.00infobox
BUB1BBgeeEpithelium of choroid plexus1.00infobox
BUB1BBgeeganglionic eminence1.00infobox
BUB1BBgeeright testis1.00infobox
BUB1BBgeebone marrow1.00infobox
BUB1BBgeeleft testis1.00infobox
BUB1BBgeetrabecular bone1.00infobox
BUB1BBgeeprimary oocyte1.00infobox
BUB1BBgeeectoderm1.00infobox
BUB1BBgeeotic vesicle1.00infobox
BUB1BBgeeprimitive streak1.00infobox
BUB1BBgeeotic placode1.00infobox
BUB1BBgeetail of embryo1.00infobox
BUB1BBgeespermatocyte1.00infobox
BUB1BBgeegenital tubercle1.00infobox
BUB1BBgeezygote1.00infobox
BUB1BBioGPSMore reference expression data1.00infobox
BUB1BChr.Chromosome 15 (human)1.00infobox
BUB1BChr.Chromosome 2 (mouse)1.00infobox
BUB1BDatabasesNCBI: entry; OMA: entry1.00infobox
BUB1BEnd40,221,123 bp1.00infobox
BUB1BEnd118,472,072 bp1.00infobox

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