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Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. Also known as BubR1, this protein is recognized for its mitotic roles in the spindle assembly checkpoint (SAC) and kinetochore-microtubule interactions that facilitate chromosome migration and alignment. BubR1 promotes mitotic fidelity…
The analysis highlights Interactions, Function and DNA repair as prominent areas in the source structure around BUB1B.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around BUB1B shows recurring relationship patterns in the source. For example, BUB1B → anaphase-promoting complex, anaphase-promoting complex-dependent catabolic process, apoptotic process, ATP binding, cell cycle, cell division, cell population proliferation, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinase activity, kinetochore, meiotic sister chromatid cohesion, centromeric, metaphase, microtubule organizing center, mitotic cell cycle, mitotic cell cycle checkpoint signaling, mitotic spindle assembly checkpoint signaling Another extracted example is BUB1B → bone marrow, ectoderm, embryo, Epithelium of choroid plexus, ganglionic eminence, genital tubercle, gonad, left testis, otic placode, otic vesicle, primary oocyte, primitive streak, right testis, secondary oocyte, spermatocyte, tail of embryo, trabecular bone, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
chromosome bubr1 checkpoint mitotic bp gene human chr band kinase 15 spindle protein location function cancer crt serine expression segregation
TTTA extracted 118 structured relationships around BUB1B. Examples in this analysis include BUB1B → 2.7.11.1 → ↗ and BUB1B → Aliases → BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| BUB1B | 2.7.11.1 | ↗ | 1.00 | infobox |
| BUB1B | Aliases | BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B | 1.00 | infobox |
| BUB1B | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WVI, 3SI5, 4GGD, 5JJA | 1.00 | infobox |
| BUB1B | Band | 15q15.1 | 1.00 | infobox |
| BUB1B | Band | 2|2 E5 | 1.00 | infobox |
| BUB1B | Bgee | secondary oocyte | 1.00 | infobox |
| BUB1B | Bgee | ventricular zone | 1.00 | infobox |
| BUB1B | Bgee | gonad | 1.00 | infobox |
| BUB1B | Bgee | embryo | 1.00 | infobox |
| BUB1B | Bgee | Epithelium of choroid plexus | 1.00 | infobox |
| BUB1B | Bgee | ganglionic eminence | 1.00 | infobox |
| BUB1B | Bgee | right testis | 1.00 | infobox |
| BUB1B | Bgee | bone marrow | 1.00 | infobox |
| BUB1B | Bgee | left testis | 1.00 | infobox |
| BUB1B | Bgee | trabecular bone | 1.00 | infobox |
| BUB1B | Bgee | primary oocyte | 1.00 | infobox |
| BUB1B | Bgee | ectoderm | 1.00 | infobox |
| BUB1B | Bgee | otic vesicle | 1.00 | infobox |
| BUB1B | Bgee | primitive streak | 1.00 | infobox |
| BUB1B | Bgee | otic placode | 1.00 | infobox |
| BUB1B | Bgee | tail of embryo | 1.00 | infobox |
| BUB1B | Bgee | spermatocyte | 1.00 | infobox |
| BUB1B | Bgee | genital tubercle | 1.00 | infobox |
| BUB1B | Bgee | zygote | 1.00 | infobox |
| BUB1B | BioGPS | More reference expression data | 1.00 | infobox |
| BUB1B | Chr. | Chromosome 15 (human) | 1.00 | infobox |
| BUB1B | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| BUB1B | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| BUB1B | End | 40,221,123 bp | 1.00 | infobox |
| BUB1B | End | 118,472,072 bp | 1.00 | infobox |
The concept neighborhoods around BUB1B bring nearby vocabulary together. In this analysis, examples include Gene, Kinase and Serine. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For BUB1B, one of the stronger structural bridges in this analysis connects BUB1B with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around BUB1B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & DNA repair, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — BUB1B · EN edition · Analysis: TopicsToTalkAbout