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Toll-like receptor 7: Clinical significance, Function & Overview

Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. It is a member of the toll-like receptor (TLR) family and detects single stranded RNA.

Language: English [EN]
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Toll-like receptor 7 topic overview

The analysis highlights Clinical significance, Function and Overview as prominent areas in the source structure around Toll-like receptor 7.

Related topics
46
Source areas
3
Connected nodes
49
Extracted relationships
102
Concept neighborhoods
18
Bridge connections
49

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 25 topics
Function · 17 topics
Overview · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TLR7, TLR7-like, toll like receptor 7, IMD74, SLEB17
Band
Xp22.2 · X|X F5
Bgee
monocyte · granulocyte · testicle · lymph node · appendix
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Toll-like receptor 7 connects Entity context

The extracted context around Toll-like receptor 7 shows recurring relationship patterns in the source. For example, Toll-like receptor 7 → cellular response to mechanical stimulus, cytoplasm, cytoplasmic vesicle, defense response to virus, double-stranded RNA binding, early phagosome, endolysosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, Golgi membrane, I-kappaB kinase/NF-kappaB signaling, I-kappaB phosphorylation, immune response, immune system process, inflammatory response, innate immune response, integral component of membrane, lysosome Another extracted example is Toll-like receptor 7 → appendix, blood, calvaria, embryo, gallbladder, granulocyte, lymph node, mesenteric lymph nodes, monocyte, parietal pleura, placenta, rectum, right coronary artery, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Toll-like receptor 7

Top relations

Gene ontology · 40
Toll-like receptor 7 → cellular response to mechanical stimulus, cytoplasm, cytoplasmic vesicle, defense response to virus, double-stranded RNA binding, early phagosome, endolysosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, Golgi membrane, I-kappaB kinase/NF-kappaB signaling, I-kappaB phosphorylation, immune response, immune system process, inflammatory response, innate immune response, integral component of membrane, lysosome
Bgee · 18
Toll-like receptor 7 → appendix, blood, calvaria, embryo, gallbladder, granulocyte, lymph node, mesenteric lymph nodes, monocyte, parietal pleura, placenta, rectum, right coronary artery, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus
RNA expression pattern · 18
Toll-like receptor 7 → appendix, blood, calvaria, embryo, gallbladder, granulocyte, lymph node, mesenteric lymph nodes, monocyte, parietal pleura, placenta, rectum, right coronary artery, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus
Band · 2
Toll-like receptor 7 → Xp22.2, X|X F5
Chr. · 2
Toll-like receptor 7 → X chromosome (human), X chromosome (mouse)
End · 2
Toll-like receptor 7 → 12,890,361 bp, 166,113,554 bp
Aliases · 1
Toll-like receptor 7 → TLR7, TLR7-like, toll like receptor 7, IMD74, SLEB17
BioGPS · 1
Toll-like receptor 7 → More reference expression data
Databases · 1
Toll-like receptor 7 → NCBI: entry; OMA: entry
Ensembl · 1
Toll-like receptor 7 → ENSG00000196664

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tlr7 rna receptor bp human gene chr band chromosome toll-like single-stranded production immunity covid-19 protein immune location function orthologs also

Toll-like receptor 7 relationships Subject–Predicate–Object triples

TTTA extracted 102 structured relationships around Toll-like receptor 7. Examples in this analysis include Toll-like receptor 7 → Aliases → TLR7, TLR7-like, toll like receptor 7, IMD74, SLEB17 and Toll-like receptor 7 → Band → Xp22.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Toll-like receptor 7AliasesTLR7, TLR7-like, toll like receptor 7, IMD74, SLEB171.00infobox
Toll-like receptor 7BandXp22.21.00infobox
Toll-like receptor 7BandX|X F51.00infobox
Toll-like receptor 7Bgeemonocyte1.00infobox
Toll-like receptor 7Bgeegranulocyte1.00infobox
Toll-like receptor 7Bgeetesticle1.00infobox
Toll-like receptor 7Bgeelymph node1.00infobox
Toll-like receptor 7Bgeeappendix1.00infobox
Toll-like receptor 7Bgeegallbladder1.00infobox
Toll-like receptor 7Bgeeparietal pleura1.00infobox
Toll-like receptor 7Bgeerectum1.00infobox
Toll-like receptor 7Bgeeright coronary artery1.00infobox
Toll-like receptor 7Bgeeplacenta1.00infobox
Toll-like receptor 7Bgeestroma of bone marrow1.00infobox
Toll-like receptor 7Bgeespleen1.00infobox
Toll-like receptor 7Bgeecalvaria1.00infobox
Toll-like receptor 7Bgeeblood1.00infobox
Toll-like receptor 7Bgeeembryo1.00infobox
Toll-like receptor 7Bgeemesenteric lymph nodes1.00infobox
Toll-like receptor 7Bgeesubcutaneous adipose tissue1.00infobox
Toll-like receptor 7Bgeethymus1.00infobox
Toll-like receptor 7BioGPSMore reference expression data1.00infobox
Toll-like receptor 7Chr.X chromosome (human)1.00infobox
Toll-like receptor 7Chr.X chromosome (mouse)1.00infobox
Toll-like receptor 7DatabasesNCBI: entry; OMA: entry1.00infobox
Toll-like receptor 7End12,890,361 bp1.00infobox
Toll-like receptor 7End166,113,554 bp1.00infobox
Toll-like receptor 7EnsemblENSG000001966641.00infobox
Toll-like receptor 7Entrez512841.00infobox
Toll-like receptor 7External IDsOMIM: 300365; MGI: 2176882; GeneCards: TLR71.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Toll-like receptor 7 bring nearby vocabulary together. In this analysis, examples include Receptor, Toll-like and Tlr. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Toll-like receptor 7
    • Receptor
    • Toll-like
    • Tlr
    • Family
    • Protein
    • Gene
    • Rna
    • Innate
    • Member
    • Mouse
    • Orthologs
    • Tlr7
  • toll-like receptor 7
    • Receptor
    • Toll-like
    • Tlr
    • Family
    • Protein
    • Gene
    • Rna
    • Function
    • Location
    • Bp
    • Chr
    • Chromosome
  • protein
    • Toll-like
    • Gene
    • Receptor
    • Innate
    • Mouse
    • Orthologs
    • Tlr
    • Agonists
    • Expressed
    • Family
    • Function
    • Humans
  • gene
    • Chromosome
    • Human
    • Location
    • Bp
    • Chr
    • Mouse
    • Receptor
    • Expressed
    • Family
    • Function
    • Protein
    • Band
  • toll-like receptor
    • Receptor
    • Toll-like
    • Tlr
    • Family
    • Protein
    • Gene
    • Rna
    • Function
    • Location
    • Bp
    • Chr
    • Chromosome
  • mitogen-activated protein kinase p38
    • Toll-like
    • Gene
    • Receptor
    • Innate
    • Mouse
    • Orthologs
    • Tlr
    • Agonists
    • Expressed
    • Family
    • Function
    • Humans
  • function
    • Location
    • Variants
    • Bp
    • Chr
    • Chromosome
    • External
    • Gene
    • Human
    • Receptor
    • Innate
    • Mouse
    • Orthologs
  • loss-of-function variants
    • Function
    • Infection
    • Loss-of-function
    • Variants
    • External
    • Found
    • Innate
    • Agonists
    • Humans
    • Location
    • Lupus
    • Response

Connections between topic areas Semantic bridges

For Toll-like receptor 7, one of the stronger structural bridges in this analysis connects Toll-like receptor 7 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Toll-like receptor 7Clinical significance · splits 24 ⟂ 26
Toll-like receptor 7Function · splits 32 ⟂ 18
Toll-like receptor 7Overview · splits 45 ⟂ 5

Map overview Semantic statistics

Toll-like receptor 7

Nodes50
Edges49
Triples102
Avg. degree1.96
Density0.04
Components1

Source & methodology

TTTA analyzes the structure around Toll-like receptor 7 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Toll-like receptor 7 · EN edition · Analysis: TopicsToTalkAbout

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