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Atorvastatin: History, Community, Culture & Applications

Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. For the prevention of cardiovascular disease, statins are a first-line treatment in reducing cholesterol. It is taken by mouth.

Language: English [EN]
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Atorvastatin topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Atorvastatin.

Related topics
156
Source areas
10
Connected nodes
166
Extracted relationships
284
Concept neighborhoods
26
Bridge connections
166

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Side effects · 43 topics
Medical uses · 24 topics
Pharmacokinetics · 19 topics
Chemical synthesis · 16 topics
Overview · 16 topics
Contraindications · 15 topics
Mechanism of action · 9 topics
History · 7 topics
Society and culture · 6 topics
Pharmacogenetics · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C10AA05 (WHO) C10BX08 (WHO) C10BX03 (WHO) C10BA05 (WHO) C10BA08 (WHO) C10BX15 (WHO) C10BX12 (WHO) C10BX06 (WHO) C10BX11 (WHO)
Bioavailability
12%
CAS Number
134523-00-5 Y
ChEBI
CHEBI:39548 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Side effects

Mechanism of action

Pharmacokinetics

Pharmacogenetics

Chemical synthesis

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Atorvastatin connects Entity context

The extracted context around Atorvastatin shows recurring relationship patterns in the source. For example, Atorvastatin → Additionally, Although, CKD, Clinical, Despite, ESRD, Evidence, Gender, Geriatric, Hemodialysis, However, Increased, Kidney, LDL, LDL-C, Liver, Pediatric, Pharmacokinetic, Plasma, Previous Another extracted example is Atorvastatin → Active, Breastfeeding, Category, Cholesterol, CPK, Drug Administration, Due, Food, HMG-CoA, In July, Markedly, Recent, Small, Statins, The, Very, When, While. Use these groups to spot repeated connection types before inspecting the individual relationships.

Atorvastatin

Top relations

related to Specific populations · 22
Atorvastatin → Additionally, Although, CKD, Clinical, Despite, ESRD, Evidence, Gender, Geriatric, Hemodialysis, However, Increased, Kidney, LDL, LDL-C, Liver, Pediatric, Pharmacokinetic, Plasma, Previous
related to Contraindications · 18
Atorvastatin → Active, Breastfeeding, Category, Cholesterol, CPK, Drug Administration, Due, Food, HMG-CoA, In July, Markedly, Recent, Small, Statins, The, Very, When, While
related to history · 17
Atorvastatin → August, Bruce Roth, CI, Co, Early, In, It, LDL, Merck, Merck's, Merck-funded, Mevacor, Nevertheless, Roger Newton, Ronald Cresswell, The Lancet, Warner-Lambert
related to Major · 16
Atorvastatin → CYP3A4, Duration, Elevations, For, However, In, It, Package, Persistent, Risk, Statin, Statin-induced, The, Type, Ultimately, Usage
related to Medication recalls · 16
Atorvastatin → Ascend Laboratories, August, Class II, FDA, Indian, March, New Jersey, November, On, On October, On September, Ranbaxy, Ranbaxy Laboratories Ltd, The, The FDA, United States
related to Pharmacogenetics · 13
Atorvastatin → Another, Caucasian, Caucasians, LDL-c, Lp, LPA, Several, SLCO1B1, SNP, SNPs, The, There, These
related to Mechanism of action · 12
Atorvastatin → As, At, HDL-cholesterol, HMG-CoA, In, Inhibition, LDL, LDL-cholesterol, Like, There, This, Unlike
related to Administration · 11
Atorvastatin → HDL, HDL-C, Hence, However, LDL, LDL-C, Statins, TC, TG, The, While
related to Excretion · 11
Atorvastatin → AUC, Bile, Child Pugh, Child-Pugh Stage, Cmax, HMG-CoA, In, Noteworthy, P-glycoprotein, People, There
related to Absorption · 9
Atorvastatin → Administration, AUC, Cmax, Evening, HMG-CoA, However, LDL-C-lowering, The, Tmax

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

statin people statins may cholesterol risk disease levels medication liver effects ldl-c concentrations cardiovascular increase also cyp3a4 plasma therapy lipitor

Atorvastatin relationships Subject–Predicate–Object triples

TTTA extracted 284 structured relationships around Atorvastatin. Examples in this analysis include Atorvastatin → 3D model (JSmol) → Interactive image and Atorvastatin → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Atorvastatin3D model (JSmol)Interactive image1.00infobox
AtorvastatinAHFS/Drugs.comMonograph1.00infobox
AtorvastatinATC codeC10AA05 (WHO) C10BX08 (WHO) C10BX03 (WHO) C10BA05 (WHO) C10BA08 (WHO) C10BX15 (WHO) C10BX12 (WHO) C10BX06 (WHO) C10BX11 (WHO)1.00infobox
AtorvastatinBioavailability12%1.00infobox
AtorvastatinCAS Number134523-00-5 Y1.00infobox
AtorvastatinChEBICHEBI:39548 Y1.00infobox
AtorvastatinChEMBLChEMBL1487 Y1.00infobox
AtorvastatinChemSpider54810 Y1.00infobox
AtorvastatinCompTox Dashboard (EPA)DTXSID80298681.00infobox
AtorvastatinDrug classHypolipidemic agent1.00infobox
AtorvastatinDrugBankAPRD00055 N1.00infobox
AtorvastatinECHA InfoCard100.125.4641.00infobox
AtorvastatinElimination half-life14 hours1.00infobox
AtorvastatinExcretionBile duct1.00infobox
AtorvastatinFormulaC33H35FN2O51.00infobox
AtorvastatinIUPHAR/BPS29491.00infobox
AtorvastatinKEGGD07474 Y1.00infobox
AtorvastatinLegal statusAU: S4 (Prescription only)1.00infobox
AtorvastatinLegal statusCA: ℞-only1.00infobox
AtorvastatinLegal statusUK: POM (Prescription only)1.00infobox
AtorvastatinLegal statusUS: ℞-only1.00infobox
AtorvastatinLegal statusEU: Rx-only1.00infobox
AtorvastatinLegal statusSE: Rx-only1.00infobox
AtorvastatinLicense dataUS DailyMed: Atorvastatin1.00infobox
AtorvastatinMedlinePlusa6000451.00infobox
AtorvastatinMetabolismLiver (CYP3A4)1.00infobox
AtorvastatinMolar mass558.650 g·mol−11.00infobox
AtorvastatinPDB ligand117 (PDBe, RCSB PDB)1.00infobox
AtorvastatinPregnancy categoryAU: D1.00infobox
AtorvastatinPregnancy categoryContraindicated1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Atorvastatin bring nearby vocabulary together. In this analysis, examples include Concentrations, Cholesterol and May. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Atorvastatin
    • Concentrations
    • Cholesterol
    • May
    • Plasma
    • Effects
    • Medication
    • People
    • Disease
    • Levels
    • Including
    • Statins
    • Risk
  • atorvastatin
    • Concentrations
    • Cholesterol
    • May
    • Plasma
    • Effects
    • Medication
    • People
    • Disease
    • Levels
    • Including
    • Statins
    • Risk
  • cardiovascular disease
    • Disease
    • People
    • Liver
    • Risk
    • Cholesterol
    • Studies
    • Statins
    • Side
    • However
    • Lipitor
    • Use
    • Ldl
  • abnormal lipid levels
    • Ldl-c
    • Risk
    • Blood
    • Evidence
    • People
    • Increase
    • Statin
    • Diabetes
    • Cholesterol
    • Higher
    • Ldl
    • Studies
  • liver
    • Hepatic
    • People
    • Side
    • Auc
    • Synthesis
    • Diabetes
    • Increase
    • Medication
    • May
    • Statins
    • Metabolism
    • Statin
  • cholesterol
    • Ldl
    • Statins
    • Including
    • Disease
    • Synthesis
    • Reduction
    • Concentrations
    • Levels
    • Blood
    • Ldl-c
    • People
    • Also
  • coronary artery disease
    • People
    • Liver
    • Risk
    • Cholesterol
    • Statins
    • However
    • Lipitor
    • Ldl
    • Increase
    • Medication
    • Hepatic
    • Levels
  • type 2 diabetes
    • People
    • Statin
    • Muscle
    • However
    • Including
    • Reduction
    • Levels
    • Blood
    • May
    • Risk
    • Evidence
    • Therapy

Connections between topic areas Semantic bridges

For Atorvastatin, one of the stronger structural bridges in this analysis connects Atorvastatin with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
AtorvastatinSide effects · splits 123 ⟂ 44
AtorvastatinMedical uses · splits 142 ⟂ 25
AtorvastatinPharmacokinetics · splits 147 ⟂ 20
AtorvastatinOverview · splits 150 ⟂ 17
AtorvastatinChemical synthesis · splits 150 ⟂ 17
AtorvastatinContraindications · splits 151 ⟂ 16
AtorvastatinMechanism of action · splits 157 ⟂ 10
AtorvastatinHistory · splits 159 ⟂ 8
AtorvastatinSociety and culture · splits 160 ⟂ 7

Map overview Semantic statistics

Atorvastatin

Nodes167
Edges166
Triples284
Avg. degree1.99
Density0.011976
Components1

Source & methodology

TTTA analyzes the structure around Atorvastatin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Atorvastatin · EN edition · Analysis: TopicsToTalkAbout

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