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Atorvastatin

Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. For the prevention of cardiovascular disease, statins are a first-line treatment in reducing cholesterol. It is taken by mouth.

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C10AA05 (WHO) C10BX08 (WHO) C10BX03 (WHO) C10BA05 (WHO) C10BA08 (WHO) C10BX15 (WHO) C10BX12 (WHO) C10BX06 (WHO) C10BX11 (WHO)
Bioavailability
12%
CAS Number
134523-00-5 Y
ChEBI
CHEBI:39548 Y

Topics to explore

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Overview

Medical uses

Contraindications

Side effects

Mechanism of action

Pharmacokinetics

Pharmacogenetics

Chemical synthesis

History

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Atorvastatin

Nodes167
Edges166
Triples284
Avg. degree1.99
Density0.011976
Components1

How this topic connects Entity context

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Atorvastatin

Top relations

related to Specific populations · 22
Atorvastatin → Additionally, Although, CKD, Clinical, Despite, ESRD, Evidence, Gender, Geriatric, Hemodialysis, However, Increased, Kidney, LDL, LDL-C, Liver, Pediatric, Pharmacokinetic, Plasma, Previous
related to Contraindications · 18
Atorvastatin → Active, Breastfeeding, Category, Cholesterol, CPK, Drug Administration, Due, Food, HMG-CoA, In July, Markedly, Recent, Small, Statins, The, Very, When, While
related to history · 17
Atorvastatin → August, Bruce Roth, CI, Co, Early, In, It, LDL, Merck, Merck's, Merck-funded, Mevacor, Nevertheless, Roger Newton, Ronald Cresswell, The Lancet, Warner-Lambert
related to Major · 16
Atorvastatin → CYP3A4, Duration, Elevations, For, However, In, It, Package, Persistent, Risk, Statin, Statin-induced, The, Type, Ultimately, Usage
related to Medication recalls · 16
Atorvastatin → Ascend Laboratories, August, Class II, FDA, Indian, March, New Jersey, November, On, On October, On September, Ranbaxy, Ranbaxy Laboratories Ltd, The, The FDA, United States
related to Pharmacogenetics · 13
Atorvastatin → Another, Caucasian, Caucasians, LDL-c, Lp, LPA, Several, SLCO1B1, SNP, SNPs, The, There, These
related to Mechanism of action · 12
Atorvastatin → As, At, HDL-cholesterol, HMG-CoA, In, Inhibition, LDL, LDL-cholesterol, Like, There, This, Unlike
related to Administration · 11
Atorvastatin → HDL, HDL-C, Hence, However, LDL, LDL-C, Statins, TC, TG, The, While
related to Excretion · 11
Atorvastatin → AUC, Bile, Child Pugh, Child-Pugh Stage, Cmax, HMG-CoA, In, Noteworthy, P-glycoprotein, People, There
related to Absorption · 9
Atorvastatin → Administration, AUC, Cmax, Evening, HMG-CoA, However, LDL-C-lowering, The, Tmax

Important terminology Word statistics

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Important terminology

statin people statins may cholesterol risk disease levels medication liver effects ldl-c concentrations cardiovascular increase also cyp3a4 plasma therapy lipitor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Atorvastatin3D model (JSmol)Interactive image1.00infobox
AtorvastatinAHFS/Drugs.comMonograph1.00infobox
AtorvastatinATC codeC10AA05 (WHO) C10BX08 (WHO) C10BX03 (WHO) C10BA05 (WHO) C10BA08 (WHO) C10BX15 (WHO) C10BX12 (WHO) C10BX06 (WHO) C10BX11 (WHO)1.00infobox
AtorvastatinBioavailability12%1.00infobox
AtorvastatinCAS Number134523-00-5 Y1.00infobox
AtorvastatinChEBICHEBI:39548 Y1.00infobox
AtorvastatinChEMBLChEMBL1487 Y1.00infobox
AtorvastatinChemSpider54810 Y1.00infobox
AtorvastatinCompTox Dashboard (EPA)DTXSID80298681.00infobox
AtorvastatinDrug classHypolipidemic agent1.00infobox
AtorvastatinDrugBankAPRD00055 N1.00infobox
AtorvastatinECHA InfoCard100.125.4641.00infobox
AtorvastatinElimination half-life14 hours1.00infobox
AtorvastatinExcretionBile duct1.00infobox
AtorvastatinFormulaC33H35FN2O51.00infobox
AtorvastatinIUPHAR/BPS29491.00infobox
AtorvastatinKEGGD07474 Y1.00infobox
AtorvastatinLegal statusAU: S4 (Prescription only)1.00infobox
AtorvastatinLegal statusCA: ℞-only1.00infobox
AtorvastatinLegal statusUK: POM (Prescription only)1.00infobox
AtorvastatinLegal statusUS: ℞-only1.00infobox
AtorvastatinLegal statusEU: Rx-only1.00infobox
AtorvastatinLegal statusSE: Rx-only1.00infobox
AtorvastatinLicense dataUS DailyMed: Atorvastatin1.00infobox
AtorvastatinMedlinePlusa6000451.00infobox
AtorvastatinMetabolismLiver (CYP3A4)1.00infobox
AtorvastatinMolar mass558.650 g·mol−11.00infobox
AtorvastatinPDB ligand117 (PDBe, RCSB PDB)1.00infobox
AtorvastatinPregnancy categoryAU: D1.00infobox
AtorvastatinPregnancy categoryContraindicated1.00infobox

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