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Aprepitant

Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting and to prevent postoperative nausea and vomiting. It may be used together with ondansetron and dexamethasone. It is taken by mouth or administered by intravenous injection. A prodrug, fosaprepitant, is also available for…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A04AD12 (WHO)
Bioavailability
60–65%
CAS Number
170729-80-3 Y
ChEBI
CHEBI:499361 Y

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Overview

Mechanism of action

Pharmacokinetics

Structure and properties

Synthesis

History

Research

Advanced semantic analysis

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Map overview Semantic statistics

Aprepitant

Nodes61
Edges60
Triples79
Avg. degree1.97
Density0.032787
Components1

How this topic connects Entity context

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Aprepitant

Top relations

related to Pharmacokinetics · 12
Aprepitant → As, Average, Before, CYP1A2, CYP2C19, CYP3A4, Following IV, L-758298, NK1, No, Seven, Specific
related to history · 6
Aprepitant → Drug Administration, FDA, In, It, United States, US Food
related to Major depression · 6
Aprepitant → Beyond, However, NK1, PET, Plans, Subsequently
related to Mechanism of action · 6
Aprepitant → In, It, NK1, SP, Substance, This
related to Synthesis · 6
Aprepitant → In, Merck, Researchers, Shortly, The, This
Legal status · 4
Aprepitant → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Structure and properties · 4
Aprepitant → C23H21F7N4O3, It, Its, These
related to Cannabinoid Hyperemesis Syndrome · 2
Aprepitant → Standard, This
3D model (JSmol) · 1
Aprepitant → Interactive image
AHFS/Drugs.com · 1
Aprepitant → Monograph

Important terminology Word statistics

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Important terminology

vomiting nk1 process used nausea synthesis receptor also ondansetron step substance receptors merck side effects use cyp3a4 drug antagonist administration

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Aprepitant3D model (JSmol)Interactive image1.00infobox
AprepitantAHFS/Drugs.comMonograph1.00infobox
AprepitantATC codeA04AD12 (WHO)1.00infobox
AprepitantBioavailability60–65%1.00infobox
AprepitantCAS Number170729-80-3 Y1.00infobox
AprepitantChEBICHEBI:499361 Y1.00infobox
AprepitantChEMBLChEMBL1471 Y1.00infobox
AprepitantChemSpider5293568 Y1.00infobox
AprepitantCompTox Dashboard (EPA)DTXSID30490471.00infobox
AprepitantDrug classNK1 receptor antagonist, antiemetic1.00infobox
AprepitantDrugBankDB00673 Y1.00infobox
AprepitantECHA InfoCard100.202.7621.00infobox
AprepitantElimination half-life9–13 hours1.00infobox
AprepitantExcretionKidney (57%), feces (45%)1.00infobox
AprepitantFormulaC23H21F7N4O31.00infobox
AprepitantIUPHAR/BPS34901.00infobox
AprepitantLegal statusAU: S4 (Prescription only)1.00infobox
AprepitantLegal statusUK: POM (Prescription only)1.00infobox
AprepitantLegal statusUS: ℞-only1.00infobox
AprepitantLegal statusEU: Rx-only1.00infobox
AprepitantLicense dataUS DailyMed: Aprepitant1.00infobox
AprepitantMedlinePlusa6040031.00infobox
AprepitantMetabolismLiver (mostly CYP3A4- mediated; some contributions by CYP2C19 & CYP1A2)1.00infobox
AprepitantMolar mass534.435 g·mol−11.00infobox
AprepitantPregnancy categoryAU: B11.00infobox
AprepitantProtein binding>95%1.00infobox
AprepitantPubChem CID69183651.00infobox
AprepitantRoutes of administrationBy mouth1.00infobox
AprepitantTrade namesEmend, Cinvanti, Aponvie, others1.00infobox
AprepitantUNII1NF15YR6UY1.00infobox

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