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Aprepitant: History & Research

Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting and to prevent postoperative nausea and vomiting. It may be used together with ondansetron and dexamethasone. It is taken by mouth or administered by intravenous injection. A prodrug, fosaprepitant, is also available for…

Language: English [EN]
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Aprepitant topic overview

The analysis highlights History and Research as prominent areas in the source structure around Aprepitant.

Related topics
53
Source areas
7
Connected nodes
60
Extracted relationships
79
Concept neighborhoods
23
Bridge connections
60

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 14 topics
Research · 11 topics
Mechanism of action · 9 topics
Structure and properties · 8 topics
Pharmacokinetics · 5 topics
Synthesis · 5 topics
History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A04AD12 (WHO)
Bioavailability
60–65%
CAS Number
170729-80-3 Y
ChEBI
CHEBI:499361 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Mechanism of action

Pharmacokinetics

Structure and properties

Synthesis

History

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Aprepitant connects Entity context

The extracted context around Aprepitant shows recurring relationship patterns in the source. For example, Aprepitant → As, Average, Before, CYP1A2, CYP2C19, CYP3A4, Following IV, L-758298, NK1, No, Seven, Specific Another extracted example is Aprepitant → Drug Administration, FDA, In, It, United States, US Food. Use these groups to spot repeated connection types before inspecting the individual relationships.

Aprepitant

Top relations

related to Pharmacokinetics · 12
Aprepitant → As, Average, Before, CYP1A2, CYP2C19, CYP3A4, Following IV, L-758298, NK1, No, Seven, Specific
related to history · 6
Aprepitant → Drug Administration, FDA, In, It, United States, US Food
related to Major depression · 6
Aprepitant → Beyond, However, NK1, PET, Plans, Subsequently
related to Mechanism of action · 6
Aprepitant → In, It, NK1, SP, Substance, This
related to Synthesis · 6
Aprepitant → In, Merck, Researchers, Shortly, The, This
Legal status · 4
Aprepitant → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Structure and properties · 4
Aprepitant → C23H21F7N4O3, It, Its, These
related to Cannabinoid Hyperemesis Syndrome · 2
Aprepitant → Standard, This
3D model (JSmol) · 1
Aprepitant → Interactive image
AHFS/Drugs.com · 1
Aprepitant → Monograph

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

vomiting nk1 process used nausea synthesis receptor also ondansetron step substance receptors merck side effects use cyp3a4 drug antagonist administration

Aprepitant relationships Subject–Predicate–Object triples

TTTA extracted 79 structured relationships around Aprepitant. Examples in this analysis include Aprepitant → 3D model (JSmol) → Interactive image and Aprepitant → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Aprepitant3D model (JSmol)Interactive image1.00infobox
AprepitantAHFS/Drugs.comMonograph1.00infobox
AprepitantATC codeA04AD12 (WHO)1.00infobox
AprepitantBioavailability60–65%1.00infobox
AprepitantCAS Number170729-80-3 Y1.00infobox
AprepitantChEBICHEBI:499361 Y1.00infobox
AprepitantChEMBLChEMBL1471 Y1.00infobox
AprepitantChemSpider5293568 Y1.00infobox
AprepitantCompTox Dashboard (EPA)DTXSID30490471.00infobox
AprepitantDrug classNK1 receptor antagonist, antiemetic1.00infobox
AprepitantDrugBankDB00673 Y1.00infobox
AprepitantECHA InfoCard100.202.7621.00infobox
AprepitantElimination half-life9–13 hours1.00infobox
AprepitantExcretionKidney (57%), feces (45%)1.00infobox
AprepitantFormulaC23H21F7N4O31.00infobox
AprepitantIUPHAR/BPS34901.00infobox
AprepitantLegal statusAU: S4 (Prescription only)1.00infobox
AprepitantLegal statusUK: POM (Prescription only)1.00infobox
AprepitantLegal statusUS: ℞-only1.00infobox
AprepitantLegal statusEU: Rx-only1.00infobox
AprepitantLicense dataUS DailyMed: Aprepitant1.00infobox
AprepitantMedlinePlusa6040031.00infobox
AprepitantMetabolismLiver (mostly CYP3A4- mediated; some contributions by CYP2C19 & CYP1A2)1.00infobox
AprepitantMolar mass534.435 g·mol−11.00infobox
AprepitantPregnancy categoryAU: B11.00infobox
AprepitantProtein binding>95%1.00infobox
AprepitantPubChem CID69183651.00infobox
AprepitantRoutes of administrationBy mouth1.00infobox
AprepitantTrade namesEmend, Cinvanti, Aponvie, others1.00infobox
AprepitantUNII1NF15YR6UY1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Aprepitant bring nearby vocabulary together. In this analysis, examples include Nk1, Vomiting and Chemotherapy-induced. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Aprepitant
    • Nk1
    • Vomiting
    • Chemotherapy-induced
    • Cyp3a4
    • Antagonist
    • Nausea
    • Receptor
    • Used
    • Synthesis
    • Medical
    • Class
    • Clinical
  • aprepitant
    • Nk1
    • Vomiting
    • Chemotherapy-induced
    • Cyp3a4
    • Antagonist
    • Nausea
    • Receptor
    • Used
    • Synthesis
    • Medical
    • Class
    • Clinical
  • chemotherapy-induced nausea and vomiting
    • Nausea
    • Vomiting
    • Prevent
    • Chemotherapy-induced
    • Used
    • Medical
    • Class
    • Receptor
    • Syndrome
    • Pain
    • Antagonist
    • Nk1
  • postoperative nausea and vomiting
    • Nausea
    • Vomiting
    • Prevent
    • Chemotherapy-induced
    • Used
    • Receptor
    • Syndrome
    • Medical
    • Class
    • Pain
    • Antagonist
    • Nk1
  • nk1 antagonist
    • Antagonist
    • Nk1
    • Receptor
    • Prevent
    • Receptors
    • Cyp3a4
    • Medical
    • Nausea
    • Used
    • Pregnancy
    • Vomiting
    • Dexamethasone
  • vomiting center
    • Nausea
    • Chemotherapy-induced
    • Prevent
    • Used
    • Syndrome
    • Receptor
    • Medical
    • Class
    • Pain
    • Antagonist
    • Aprepitant
    • Nk1
  • vomiting
    • Nausea
    • Chemotherapy-induced
    • Prevent
    • Used
    • Syndrome
    • Receptor
    • Medical
    • Class
    • Pain
    • Antagonist
    • Aprepitant
    • Nk1
  • food and drug administration
    • Synthesis
    • Clinical
    • Drug
    • Merck
    • Pregnancy
    • Approved
    • Intravenous
    • Medical
    • Prevent
    • Chemotherapy-induced
    • Class
    • Cyp3a4

Connections between topic areas Semantic bridges

For Aprepitant, one of the stronger structural bridges in this analysis connects Aprepitant with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Aprepitant — Overview · splits 46 ⟂ 15
Aprepitant — Research · splits 49 ⟂ 12
Aprepitant — Mechanism of action · splits 51 ⟂ 10
Aprepitant — Structure and properties · splits 52 ⟂ 9
Aprepitant — Pharmacokinetics · splits 55 ⟂ 6
Aprepitant — Synthesis · splits 55 ⟂ 6

Map overview Semantic statistics

Aprepitant

Nodes61
Edges60
Triples79
Avg. degree1.97
Density0.032787
Components1

Source & methodology

TTTA analyzes the structure around Aprepitant to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Aprepitant · EN edition · Analysis: TopicsToTalkAbout

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