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Telithromycin

Telithromycin is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek. It is used to treat community acquired pneumonia of mild to moderate severity. After significant safety concerns, the US Food and Drug Administration sharply curtailed the approved uses of the drug in early 2007.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J01FA15 (WHO)
Bioavailability
57%
CAS Number
191114-48-4 Y
ChEBI
CHEBI:29688

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Overview

Adverse effects

Mechanism of action

Pharmacokinetics

History

Advanced semantic analysis

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Map overview Semantic statistics

Telithromycin

Nodes32
Edges31
Triples75
Avg. degree1.94
Density0.0625
Components1

How this topic connects Entity context

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Telithromycin

Top relations

related to history · 14
Telithromycin → April, Drug Administration, European Commission, FDA, Food, French, HMR-3647, Hoechst Marion Roussel, II/III, In, July, October, Sanofi-Aventis, US
related to External links · 12
Telithromycin → Annals, Article, FDA Public Health Advisory, Internal Medicine, Ketek, KETEK Oral, Ketek'Drugs, Login, Patient Handout, Treatments, WebMD, York Times
has effect · 7
Telithromycin → Headache, Less, March, Most, Prolonged QTc, Rare, Three
related to Pharmacokinetics · 7
Telithromycin → Due, During, It, L-cladinose, Streptococcus, The, Unlike
related to Mechanism of action · 3
Telithromycin → In, Like, RNA
Legal status · 2
Telithromycin → UK: POM (Prescription only), US: ℞-only
is a · 2
Telithromycin → first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek, semi-synthetic erythromycin derivative
related to Metabolism · 2
Telithromycin → About, Telithromycin's
3D model (JSmol) · 1
Telithromycin → Interactive image
AHFS/Drugs.com · 1
Telithromycin → Monograph

Important terminology Word statistics

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Important terminology

fda ketek liver safety 2006 approval approved sanofi-aventis also one cases patients clinical drug ring carbamate data us administration antibiotic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Telithromycin3D model (JSmol)Interactive image1.00infobox
TelithromycinAHFS/Drugs.comMonograph1.00infobox
TelithromycinATC codeJ01FA15 (WHO)1.00infobox
TelithromycinBioavailability57%1.00infobox
TelithromycinCAS Number191114-48-4 Y1.00infobox
TelithromycinChEBICHEBI:296881.00infobox
TelithromycinChEMBLChEMBL1136 Y1.00infobox
TelithromycinChemSpider2273373 Y1.00infobox
TelithromycinCompTox Dashboard (EPA)DTXSID30464551.00infobox
TelithromycinDrugBankDB00976 Y1.00infobox
TelithromycinECHA InfoCard100.208.2061.00infobox
TelithromycinElimination half-life10 hours1.00infobox
TelithromycinExcretionBiliary and renal1.00infobox
TelithromycinFormulaC43H65N5O101.00infobox
TelithromycinKEGGD01078 N1.00infobox
TelithromycinLegal statusUK: POM (Prescription only)1.00infobox
TelithromycinLegal statusUS: ℞-only1.00infobox
TelithromycinLicense dataEU EMA: by INN1.00infobox
TelithromycinMedlinePlusa6040261.00infobox
TelithromycinMelting point177 °C (351 °F)1.00infobox
TelithromycinMetabolismHepatic (50% CYP3A4-mediated)1.00infobox
TelithromycinMolar mass812.018 g·mol−11.00infobox
TelithromycinProtein binding66% to 79%1.00infobox
TelithromycinPubChem CID54625161.00infobox
TelithromycinRoutes of administrationOral1.00infobox
TelithromycinTrade namesKetek, others1.00infobox
TelithromycinUNIIKI8H7H19WL1.00infobox
Telithromycinis afirst ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek0.90text
Telithromycinis asemi-synthetic erythromycin derivative0.90text

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