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Lysosome

A lysosome (/ˈlaɪsəˌsoʊm/) is a membrane-bound organelle that is found in all animal cells (except red blood cells), and rarely in plant cells. There are normally hundreds of lysosomes in the cytosol, where they function as the cell's degradation center. Their primary responsibility is for catabolic degradation of proteins, polysaccharides and lipids…

Function and structure, Discovery & Pathogen entry

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Overview

Discovery

Function and structure

Lysosomal degradation pathways

Pathogen entry

Clinical significance

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Map overview Semantic statistics

Lysosome

Nodes50
Edges49
Triples106
Avg. degree1.96
Density0.04
Components1

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Lysosome

Top relations

related to External links · 36
Lysosome → Animation, Archived, Cells May Hold Key, Changsoo, December, Dennis, Donna, Drayna, February, Friedman, James, Jennifer, Krasnewich, Longer LifeKang, Lysosomal Enzyme, Medicine, Mullikin, Mundorff, Mutations, NCATS/Rare Diseases Clinical Research
related to Discovery · 15
Lysosome → Belgian, Catholic University, Christian, De Duve, De Duve's, Duve, Laboratory, Louvain, Medicine, Nobel Prize, Physiological Chemistry, Physiology, The, This, Using
related to Pathogen entry · 7
Lysosome → APCs, Fragments, II, Lysosomes, MHC II, This, When
related to Systemic lupus erythematosus (Lupus) · 6
Lysosome → As, DNA, Lupus, SLE, Systemic, The
related to Formation · 5
Lysosome → Early, Golgi, The, These, This
related to Function and structure · 5
Lysosome → However, Lysosomes, Several, The, Their
related to Lysosomal degradation pathways · 5
Lysosome → Endocytosed, MVBs, The, Then, This
related to Clinical significance · 4
Lysosome → Lysosomal, Most, The, This
related to Lysosomotropism · 4
Lysosome → Lysosomotropism, Many, This, While
related to Different types of enzymes present in lysosomes · 2
Lysosome → It, There

Important terminology Word statistics

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Important terminology

lysosomes lysosomal cell enzymes membrane degradation autophagy immune acidic proteins also organelles function cytosol disorders cells molecules environment via hydrolytic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
acid phosphatase within cellsinstance ofDe Duve and his team were studying the distribution of hydrolytic enzymes0.80text
using cell fractionation methods to isolate subcellular componentsinstance ofDe Duve and his team were studying the distribution of hydrolytic enzymes0.80text
misfolded- or polyubiquitinated proteinsinstance ofAfter merging with lysosomes they create hybrid organelles called autolysosomes.Macroautophagy involves the formation of isolated double- or multi-membranes that encapsulate por…0.80text
lipidsinstance ofAfter merging with lysosomes they create hybrid organelles called autolysosomes.Macroautophagy involves the formation of isolated double- or multi-membranes that encapsulate por…0.80text
damaged or aged organellesinstance ofAfter merging with lysosomes they create hybrid organelles called autolysosomes.Macroautophagy involves the formation of isolated double- or multi-membranes that encapsulate por…0.80text
RNAinstance ofAfter merging with lysosomes they create hybrid organelles called autolysosomes.Macroautophagy involves the formation of isolated double- or multi-membranes that encapsulate por…0.80text
and fragments of the ERinstance ofAfter merging with lysosomes they create hybrid organelles called autolysosomes.Macroautophagy involves the formation of isolated double- or multi-membranes that encapsulate por…0.80text
V-ATPaseinstance ofwhich includes components0.80text
Rag GTPasesinstance ofwhich includes components0.80text
and the mTOR complexinstance ofwhich includes components0.80text
viruses or bacteriainstance ofPathogen entryLysosomes are a crucial component of the innate immune system and play an important role in defending the cell against pathogens0.80text
HIVinstance ofPoor lysosomal activity and failure by lysosomes to properly degrade all biomolecules from pathogens results in higher viral infections by viruses0.80text

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