NLRC4

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Explore the main themes, entities and connections around NLRC4. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Inflammasome ASC APAF1 NOD1 NOD2

9 related topics

Structure

C. elegans CARD NACHT LRR CIITA

6 related topics

Clinical significance

Autoinflammatory Macrophage Activation Syndrome (MAS)IL-18 Cryopyrin Associated Periodic Syndromes

4 related topics

Interactions

Interact CASP1

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: NLRC4, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF, AIFEC, FCAS4, NLR family, CARD domain containing 4, NLR family CARD domain containing 4
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KXF
Band: 2p22.3 · 17|17 E2
Bgee: monocyte · blood · granulocyte · gonad · trabecular bone
BioGPS: n/a
Chr.: Chromosome 2 (human) · Chromosome 17 (mouse)

Topics to explore

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Overview

Structure

C. elegans Caenorhabditis elegans
CARD CARD domain
NACHT NACHT domain
LRR Leucine-rich repeat
CIITA
NLRP3 NALP3

Function

Interactions

Interact Protein-protein interaction
CASP1 Caspase 1

Clinical significance

Autoinflammatory Periodic fever syndrome
Macrophage Activation Syndrome (MAS) Macrophage activation syndrome
IL-18 Interleukin 18
Cryopyrin Associated Periodic Syndromes Neonatal onset multisystem inflammatory disease

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes29

Edges28

Triples134

Avg. degree1.93

Density0.068966

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

NLRC4

Top relations

Gene ontology · 31

NLRC4 → activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of innate immune response, apoptotic process, ATP binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytoplasm, cytosol, defense response to bacterium, detection of bacterium, identical protein binding, immune system process, inflammatory response, inhibition of cysteine-type endopeptidase activity involved in apoptotic process, innate immune response, intracellular anatomical structure, IPAF inflammasome complex, magnesium ion binding, mitotic spindle assembly, nucleotide binding, nucleus

Bgee · 19

NLRC4 → appendix, blood, bone marrow, bone marrow cell, colon, duodenum, gonad, granulocyte, ileum, jejunum, monocyte, primary oocyte, proximal tubule, secondary oocyte, spleen, stomach, testicle, trabecular bone, zygote

RNA expression pattern · 19

related to Function · 17

NLRC4 → APAF1, ASC, C-terminal, CARD12, CARD15, CARD4, Ced4, Human Ced4, LRRs, N-terminal CARD, NACHT, NBD, NOD1, NOD2, These, Unlike NLRP3, WD40

related to Structure · 10

NLRC4 → C-terminal, Ced4, CIITA, It, LRR, N-terminal CARD, NACHT, NLR, NLRP3, The NLRC4

related to Clinical significance · 9

NLRC4 → Cryopyrin Associated Periodic Syndromes, Humans, IL-18, In, Japanese, Macrophage Activation Syndrome, MAS, NLRP3, Some

related to Interactions · 6

NLRC4 → CASP1, NAIP, NLRC4-dependent, NLRP3, The NAIP/NLRC4, Under

Band · 2

NLRC4 → 17|17 E2, 2p22.3

Chr. · 2

NLRC4 → Chromosome 17 (mouse), Chromosome 2 (human)

End · 2

NLRC4 → 32,265,732 bp, 74,766,137 bp

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp inflammasome family chr band protein gene card chromosome nlrp3 nlr location structure mouse domain function ced4 proteins associated

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
NLRC4	Aliases	NLRC4, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF, AIFEC, FCAS4, NLR family, CARD domain containing 4, NLR family CARD domain containing 4	1.00	infobox
NLRC4	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KXF	1.00	infobox
NLRC4	Band	2p22.3	1.00	infobox
NLRC4	Band	17\|17 E2	1.00	infobox
NLRC4	Bgee	monocyte	1.00	infobox
NLRC4	Bgee	blood	1.00	infobox
NLRC4	Bgee	granulocyte	1.00	infobox
NLRC4	Bgee	gonad	1.00	infobox
NLRC4	Bgee	trabecular bone	1.00	infobox
NLRC4	Bgee	testicle	1.00	infobox
NLRC4	Bgee	bone marrow	1.00	infobox
NLRC4	Bgee	bone marrow cell	1.00	infobox
NLRC4	Bgee	spleen	1.00	infobox
NLRC4	Bgee	appendix	1.00	infobox
NLRC4	Bgee	jejunum	1.00	infobox
NLRC4	Bgee	ileum	1.00	infobox
NLRC4	Bgee	zygote	1.00	infobox
NLRC4	Bgee	duodenum	1.00	infobox
NLRC4	Bgee	colon	1.00	infobox
NLRC4	Bgee	secondary oocyte	1.00	infobox
NLRC4	Bgee	primary oocyte	1.00	infobox
NLRC4	Bgee	proximal tubule	1.00	infobox
NLRC4	Bgee	stomach	1.00	infobox
NLRC4	BioGPS	n/a	1.00	infobox
NLRC4	Chr.	Chromosome 2 (human)	1.00	infobox
NLRC4	Chr.	Chromosome 17 (mouse)	1.00	infobox
NLRC4	Databases	NCBI: entry; OMA: entry	1.00	infobox
NLRC4	End	32,265,732 bp	1.00	infobox
NLRC4	End	74,766,137 bp	1.00	infobox
NLRC4	Ensembl	ENSG00000091106	1.00	infobox

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