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AIM2

Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.

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Aliases
AIM2, PYHIN4, absent in melanoma 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3RN2, 3RN5, 3VD8, 4O7Q
Band
1q23.1|1q23.1-q23.2 · 1|1 H3
Bgee
lymph node · spleen · sperm · monocyte · appendix
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Structure

Function

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Clinical relevance

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Map overview Semantic statistics

AIM2

Nodes62
Edges61
Triples147
Avg. degree1.97
Density0.032258
Components1

How this topic connects Entity context

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AIM2

Top relations

Gene ontology · 25
AIM2 → activation of innate immune response, AIM2 inflammasome complex, apoptotic process, cellular response to interferon-beta, cytoplasm, cytosol, DNA binding, double-stranded DNA binding, identical protein binding, immune response, immune system process, inflammatory response, innate immune response, mitochondrion, negative regulation of NF-kappaB transcription factor activity, nucleoplasm, nucleus, positive regulation of cysteine-type endopeptidase activity, positive regulation of defense response to virus by host, positive regulation of interleukin-1 beta production
related to Function · 20
AIM2 → AIM2-PANoptosome, ASC, B-form, Binding, CARD, CARD-CARD, Caspase-1, DNA, However, IL-18, IL-1β, PANoptosis, PYD, PYD-CARD-containing, PYD-PYD, The, The HIN, The N-terminal, This AIM2, Together
Bgee · 19
AIM2 → appendix, blood, embryo, epithelium of nasopharynx, genital tubercle, gonad, granulocyte, lateral geniculate nucleus, left colon, lymph node, medial geniculate nucleus, monocyte, pituitary gland, sperm, spleen, subiculum, superficial temporal artery, thymus, ventricular zone
RNA expression pattern · 19
AIM2 → appendix, blood, embryo, epithelium of nasopharynx, genital tubercle, gonad, granulocyte, lateral geniculate nucleus, left colon, lymph node, medial geniculate nucleus, monocyte, pituitary gland, sperm, spleen, subiculum, superficial temporal artery, thymus, ventricular zone
related to Regulation · 15
AIM2 → According, Analogously, ASC, DNA, DNA-induced, HIN, HIN2, IFI16-designated IFI16-β, IFI16-β, It, Its, PYD, Regulation, The HIN1, When
related to Structure · 10
AIM2 → ALR, C-terminal HIN-200, DNA, HIN, N-terminal, N-terminal PYD, OB, Proteins, PYD, The PYD
related to Inflammatory, autoimmune, and other pathological conditions · 7
AIM2 → Aberrant, DNA, Elevated, In, Increased, Moreover, The
related to Cancer · 4
AIM2 → AKT, However, Recent, The
Band · 2
AIM2 → 1q23.1|1q23.1-q23.2, 1|1 H3
Chr. · 2
AIM2 → Chromosome 1 (human), Chromosome 1 (mouse)

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Important terminology

inflammasome dna human protein domain binding asc also bp gene panoptosis host inflammatory dsdna pyd chr band mouse defense two

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
AIM2AliasesAIM2, PYHIN4, absent in melanoma 21.00infobox
AIM2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3RN2, 3RN5, 3VD8, 4O7Q1.00infobox
AIM2Band1q23.1|1q23.1-q23.21.00infobox
AIM2Band1|1 H31.00infobox
AIM2Bgeelymph node1.00infobox
AIM2Bgeespleen1.00infobox
AIM2Bgeesperm1.00infobox
AIM2Bgeemonocyte1.00infobox
AIM2Bgeeappendix1.00infobox
AIM2Bgeesuperficial temporal artery1.00infobox
AIM2Bgeeblood1.00infobox
AIM2Bgeepituitary gland1.00infobox
AIM2Bgeeepithelium of nasopharynx1.00infobox
AIM2Bgeegonad1.00infobox
AIM2Bgeegranulocyte1.00infobox
AIM2Bgeeventricular zone1.00infobox
AIM2Bgeethymus1.00infobox
AIM2Bgeeleft colon1.00infobox
AIM2Bgeeembryo1.00infobox
AIM2Bgeesubiculum1.00infobox
AIM2Bgeegenital tubercle1.00infobox
AIM2Bgeelateral geniculate nucleus1.00infobox
AIM2Bgeemedial geniculate nucleus1.00infobox
AIM2BioGPSMore reference expression data1.00infobox
AIM2Chr.Chromosome 1 (human)1.00infobox
AIM2Chr.Chromosome 1 (mouse)1.00infobox
AIM2DatabasesNCBI: entry; OMA: entry1.00infobox
AIM2End159,187,843 bp1.00infobox
AIM2End173,466,040 bp1.00infobox
AIM2EnsemblENSG000001635681.00infobox

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