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Isocarboxazid

Isocarboxazid, sold under the brand name Marplan among others, is a non-selective irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class. Along with phenelzine and tranylcypromine, it is one of the three classic irreversible, non-selective MAOIs used as antidepressants in modern psychiatric practice. Availability varies by country; in the…

Standards, Contraindications and precautions & Pharmacology

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Consumer Drug Information
ATC code
N06AF01 (WHO)
Bioavailability
Low, peak at 1–2 h
CAS Number
59-63-2 Y
ChEMBL
ChEMBL1201168 N

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Overview

Pharmacology

Adverse effects and interactions

Contraindications and precautions

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Map overview Semantic statistics

Isocarboxazid

Nodes64
Edges63
Triples89
Avg. degree1.97
Density0.03125
Components1

How this topic connects Entity context

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Isocarboxazid

Top relations

related to Contraindications and precautions · 24
Isocarboxazid → Antihypertensive, Certain, Classic MAOI-to-classic MAOI, Cocaine, Drugs, Foods, Improved, In, Low-dose, MAO-A, MAO-B, MAOI, MAOIs, MDMA, Medium, Other, Pheochromocytoma, Severe, Significant, Some
related to history · 12
Isocarboxazid → American Society, Drug Administration, During, Food, Health-System Pharmacists, In, Lifsa Pharma, Lifsa's, Marplan, United States, Validus, Validus Pharmaceuticals
related to Pharmacokinetics · 5
Isocarboxazid → As, CYP2D6, It, Its, This CYP2D6-independent
Legal status · 3
Isocarboxazid → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), In general: ℞ (Prescription only)
has effect · 3
Isocarboxazid → Despite, MAOIs, The
related to Pharmacodynamics · 3
Isocarboxazid → MAOIs, This, Unlike
3D model (JSmol) · 1
Isocarboxazid → Interactive image
AHFS/Drugs.com · 1
Isocarboxazid → Consumer Drug Information
ATC code · 1
Isocarboxazid → N06AF01 (WHO)
Bioavailability · 1
Isocarboxazid → Low, peak at 1–2 h

Important terminology Word statistics

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Important terminology

classic also maoi phenelzine effects used drugs tranylcypromine maois use including adverse treatment although antidepressant inhibitors dose reactions rather reported

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Isocarboxazid3D model (JSmol)Interactive image1.00infobox
IsocarboxazidAHFS/Drugs.comConsumer Drug Information1.00infobox
IsocarboxazidATC codeN06AF01 (WHO)1.00infobox
IsocarboxazidBioavailabilityLow, peak at 1–2 h1.00infobox
IsocarboxazidCAS Number59-63-2 Y1.00infobox
IsocarboxazidChEMBLChEMBL1201168 N1.00infobox
IsocarboxazidChemSpider3628 Y1.00infobox
IsocarboxazidCompTox Dashboard (EPA)DTXSID40231711.00infobox
IsocarboxazidDrugBankDB01247 Y1.00infobox
IsocarboxazidECHA InfoCard100.000.3991.00infobox
IsocarboxazidElimination half-life1.5–4 h1.00infobox
IsocarboxazidExcretionUrine1.00infobox
IsocarboxazidFormulaC12H13N3O21.00infobox
IsocarboxazidIUPHAR/BPS72041.00infobox
IsocarboxazidKEGGD02580 Y1.00infobox
IsocarboxazidLegal statusAU: S4 (Prescription only)1.00infobox
IsocarboxazidLegal statusBR: Class C1 (Other controlled substances)1.00infobox
IsocarboxazidLegal statusIn general: ℞ (Prescription only)1.00infobox
IsocarboxazidMedlinePlusa6050361.00infobox
IsocarboxazidMetabolismLiver (Carboxylesterase)1.00infobox
IsocarboxazidMetabolitesHippuric acid1.00infobox
IsocarboxazidMolar mass231.255 g·mol−11.00infobox
IsocarboxazidPubChem CID37591.00infobox
IsocarboxazidRoutes of administrationBy mouth1.00infobox
IsocarboxazidTrade namesMarplan, Enerzer1.00infobox
IsocarboxazidUNII34237V843T1.00infobox

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