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Integrin beta 1: Function, Interactions & Overview

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and…

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Integrin beta 1 topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around Integrin beta 1.

Related topics
65
Source areas
5
Connected nodes
70
Extracted relationships
178
Concept neighborhoods
23
Bridge connections
70

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 22 topics
Interactions · 17 topics
Overview · 17 topics
Structure · 5 topics
Clinical significance · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4WK4, 3G9W, 3T9K, 3VI3, 3VI4, 4DX9, 4WJK, 4WK0, 4WK2
Band
10p11.22 · 8|8 E2
Bgee
visceral pleura · seminal vesicula · tail of epididymis · parietal pleura · stromal cell of endometrium
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Integrin beta 1 connects Entity context

The extracted context around Integrin beta 1 shows recurring relationship patterns in the source. For example, Integrin beta 1 → actin binding, axon extension, B cell differentiation, basement membrane organization, C-X3-C chemokine binding, cadherin binding, calcium-independent cell-matrix adhesion, cardiac muscle cell differentiation, cardiac muscle tissue development, cell adhesion, cell adhesion mediated by integrin, cell adhesion molecule binding, cell fate specification, cell junction, cell migration, cell migration involved in sprouting angiogenesis, cell projection, cell projection organization, cell surface, cell-cell adhesion mediated by integrin Another extracted example is Integrin beta 1 → atrium, calvaria, cardiac muscle tissue of left ventricle, Descending thoracic aorta, extraocular muscle, Ileal epithelium, lactiferous gland, left lung lobe, palpebral conjunctiva, parietal pleura, seminal vesicula, smooth muscle tissue, stroma of bone marrow, stromal cell of endometrium, superficial temporal artery, tail of epididymis, tibia, umbilical cord, uterus, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

Integrin beta 1

Top relations

Gene ontology · 115
Integrin beta 1 → actin binding, axon extension, B cell differentiation, basement membrane organization, C-X3-C chemokine binding, cadherin binding, calcium-independent cell-matrix adhesion, cardiac muscle cell differentiation, cardiac muscle tissue development, cell adhesion, cell adhesion mediated by integrin, cell adhesion molecule binding, cell fate specification, cell junction, cell migration, cell migration involved in sprouting angiogenesis, cell projection, cell projection organization, cell surface, cell-cell adhesion mediated by integrin
Bgee · 20
Integrin beta 1 → atrium, calvaria, cardiac muscle tissue of left ventricle, Descending thoracic aorta, extraocular muscle, Ileal epithelium, lactiferous gland, left lung lobe, palpebral conjunctiva, parietal pleura, seminal vesicula, smooth muscle tissue, stroma of bone marrow, stromal cell of endometrium, superficial temporal artery, tail of epididymis, tibia, umbilical cord, uterus, visceral pleura
RNA expression pattern · 20
Integrin beta 1 → atrium, calvaria, cardiac muscle tissue of left ventricle, Descending thoracic aorta, extraocular muscle, Ileal epithelium, lactiferous gland, left lung lobe, palpebral conjunctiva, parietal pleura, seminal vesicula, smooth muscle tissue, stroma of bone marrow, stromal cell of endometrium, superficial temporal artery, tail of epididymis, tibia, umbilical cord, uterus, visceral pleura
Band · 2
Integrin beta 1 → 10p11.22, 8|8 E2
Chr. · 2
Integrin beta 1 → Chromosome 10 (human), Chromosome 8 (mouse)
End · 2
Integrin beta 1 → 129,459,681 bp, 33,005,792 bp
Aliases · 1
Integrin beta 1 → ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
Available structures · 1
Integrin beta 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4WK4, 3G9W, 3T9K, 3VI3, 3VI4, 4DX9, 4WJK, 4WK0, 4WK2
BioGPS · 1
Integrin beta 1 → More reference expression data
Databases · 1
Integrin beta 1 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

integrin beta-1d bp gene human beta-1 cytoplasmic beta cell isoform chr band function alpha 10 itgb1 muscle expressed cardiac receptors

Integrin beta 1 relationships Subject–Predicate–Object triples

TTTA extracted 178 structured relationships around Integrin beta 1. Examples in this analysis include Integrin beta 1 → Aliases → ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1 and Integrin beta 1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4WK4, 3G9W, 3T9K, 3VI3, 3VI4, 4DX9, 4WJK, 4WK0, 4WK2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Integrin beta 1AliasesITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 11.00infobox
Integrin beta 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4WK4, 3G9W, 3T9K, 3VI3, 3VI4, 4DX9, 4WJK, 4WK0, 4WK21.00infobox
Integrin beta 1Band10p11.221.00infobox
Integrin beta 1Band8|8 E21.00infobox
Integrin beta 1Bgeevisceral pleura1.00infobox
Integrin beta 1Bgeeseminal vesicula1.00infobox
Integrin beta 1Bgeetail of epididymis1.00infobox
Integrin beta 1Bgeeparietal pleura1.00infobox
Integrin beta 1Bgeestromal cell of endometrium1.00infobox
Integrin beta 1Bgeetibia1.00infobox
Integrin beta 1Bgeesmooth muscle tissue1.00infobox
Integrin beta 1Bgeesuperficial temporal artery1.00infobox
Integrin beta 1BgeeDescending thoracic aorta1.00infobox
Integrin beta 1Bgeepalpebral conjunctiva1.00infobox
Integrin beta 1BgeeIleal epithelium1.00infobox
Integrin beta 1Bgeestroma of bone marrow1.00infobox
Integrin beta 1Bgeelactiferous gland1.00infobox
Integrin beta 1Bgeeleft lung lobe1.00infobox
Integrin beta 1Bgeecardiac muscle tissue of left ventricle1.00infobox
Integrin beta 1Bgeeumbilical cord1.00infobox
Integrin beta 1Bgeeatrium1.00infobox
Integrin beta 1Bgeeuterus1.00infobox
Integrin beta 1Bgeecalvaria1.00infobox
Integrin beta 1Bgeeextraocular muscle1.00infobox
Integrin beta 1BioGPSMore reference expression data1.00infobox
Integrin beta 1Chr.Chromosome 10 (human)1.00infobox
Integrin beta 1Chr.Chromosome 8 (mouse)1.00infobox
Integrin beta 1DatabasesNCBI: entry; OMA: entry1.00infobox
Integrin beta 1End33,005,792 bp1.00infobox
Integrin beta 1End129,459,681 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Integrin beta 1 bring nearby vocabulary together. In this analysis, examples include External, Beta-1d and Chromosome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Integrin beta 1
    • External
    • Beta-1d
    • Chromosome
    • Extracellular
    • Location
    • Bp
    • Cell
    • Chr
    • Human
    • Function
    • Cytoplasmic
    • Different
  • integrin beta 1
    • External
    • Isoforms
    • Beta-1d
    • Chromosome
    • Different
    • Expressed
    • Extracellular
    • Itgb1
    • Location
    • Bp
    • Cell
    • Chr
  • cell surface receptor
    • Cardiac
    • Itgb1
    • Function
    • Muscle
    • Cell
    • Gene
    • Surface
    • Also
    • Beta-1
    • Costameres
    • External
    • Integrin
  • integrin
    • Beta-1d
    • Cell
    • Function
    • Cytoplasmic
    • Different
    • Domain
    • Expressed
    • Receptors
    • Beta
    • Muscle
    • Isoforms
    • Levels
  • integrin alpha 1
    • Form
    • Beta-1d
    • Receptors
    • Cell
    • Function
    • Cytoplasmic
    • Also
    • Complexes
    • Different
    • Domain
    • Expressed
    • Beta
  • integrin alpha 2
    • Form
    • Beta-1d
    • Receptors
    • Cell
    • Function
    • Cytoplasmic
    • Also
    • Complexes
    • Different
    • Domain
    • Expressed
    • Beta
  • integrin alpha 3
    • Form
    • Beta-1d
    • Receptors
    • Cell
    • Function
    • Cytoplasmic
    • Also
    • Complexes
    • Different
    • Domain
    • Expressed
    • Beta
  • cardiac muscle
    • Muscle
    • Skeletal
    • Costameres
    • Matrix
    • Surface
    • Cells
    • Expressed
    • Extracellular
    • Beta-1d
    • Function
    • Isoform
    • External

Connections between topic areas Semantic bridges

For Integrin beta 1, one of the stronger structural bridges in this analysis connects Integrin beta 1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Integrin beta 1Function · splits 48 ⟂ 23
Integrin beta 1Overview · splits 53 ⟂ 18
Integrin beta 1Interactions · splits 53 ⟂ 18
Integrin beta 1Structure · splits 65 ⟂ 6
Integrin beta 1Clinical significance · splits 66 ⟂ 5

Map overview Semantic statistics

Integrin beta 1

Nodes71
Edges70
Triples178
Avg. degree1.97
Density0.028169
Components1

Source & methodology

TTTA analyzes the structure around Integrin beta 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Integrin beta 1 · EN edition · Analysis: TopicsToTalkAbout

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