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Integrin alpha 2: Biological functions, Clinical significance & Immune function

Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a transmembrane protein which in humans is encoded by the CD49b gene.

Language: English [EN]
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Integrin alpha 2 topic overview

The analysis highlights Biological functions, Clinical significance and Immune function as prominent areas in the source structure around Integrin alpha 2. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
103
Source areas
7
Connected nodes
111
Extracted relationships
162
Concept neighborhoods
35
Bridge connections
111

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 29 topics
Biological functions · 21 topics
Immune function · 16 topics
Overview · 13 topics
Structure · 13 topics
Ligands · 10 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AOX, 1DZI, 1V7P, 4BJ3
Band
5q11.2 · 13 D2.2|13 64.61 cM
Bgee
ventricular zone · epithelium of nasopharynx · bronchial epithelial cell · islet of Langerhans · visceral pleura
BioGPS
n/a
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Structure

Ligands

Biological functions

Immune function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Integrin alpha 2 connects Entity context

The extracted context around Integrin alpha 2 shows recurring relationship patterns in the source. For example, Integrin alpha 2 → amyloid-beta binding, animal organ morphogenesis, axon, axon terminus, basal part of cell, blood coagulation, cell adhesion, cell adhesion mediated by integrin, cell population proliferation, cell projection, cell surface, cell-matrix adhesion, cell-substrate adhesion, cellular response to estradiol stimulus, cellular response to mechanical stimulus, cellular response to organic cyclic compound, collagen binding, collagen binding involved in cell-matrix adhesion, collagen receptor activity, collagen-activated signaling pathway Another extracted example is Integrin alpha 2 → blood, bronchial epithelial cell, cumulus cell, decidua, epithelium of nasopharynx, gastrula, gingival epithelium, islet of Langerhans, left lung lobe, lumbar spinal ganglion, molar, Paneth cell, seminal vesicula, skin of hip, skin of thigh, stellate reticulum, trigeminal ganglion, ventricular zone, visceral pleura, vulva. Use these groups to spot repeated connection types before inspecting the individual relationships.

Integrin alpha 2

Top relations

Gene ontology · 74
Integrin alpha 2 → amyloid-beta binding, animal organ morphogenesis, axon, axon terminus, basal part of cell, blood coagulation, cell adhesion, cell adhesion mediated by integrin, cell population proliferation, cell projection, cell surface, cell-matrix adhesion, cell-substrate adhesion, cellular response to estradiol stimulus, cellular response to mechanical stimulus, cellular response to organic cyclic compound, collagen binding, collagen binding involved in cell-matrix adhesion, collagen receptor activity, collagen-activated signaling pathway
Bgee · 20
Integrin alpha 2 → blood, bronchial epithelial cell, cumulus cell, decidua, epithelium of nasopharynx, gastrula, gingival epithelium, islet of Langerhans, left lung lobe, lumbar spinal ganglion, molar, Paneth cell, seminal vesicula, skin of hip, skin of thigh, stellate reticulum, trigeminal ganglion, ventricular zone, visceral pleura, vulva
RNA expression pattern · 20
Integrin alpha 2 → blood, bronchial epithelial cell, cumulus cell, decidua, epithelium of nasopharynx, gastrula, gingival epithelium, islet of Langerhans, left lung lobe, lumbar spinal ganglion, molar, Paneth cell, seminal vesicula, skin of hip, skin of thigh, stellate reticulum, trigeminal ganglion, ventricular zone, visceral pleura, vulva
related to External links · 12
Integrin alpha 2 → CD49b, Cell Migration Gateway, CS1, Human Integrin, Human ITGA2, ITGA2, Medicine Medical Subject Headings, MeSH, National Library, PDB, PDBe-KB, UCSC Genome Browser
Band · 2
Integrin alpha 2 → 13 D2.2|13 64.61 cM, 5q11.2
Chr. · 2
Integrin alpha 2 → Chromosome 13 (mouse), Chromosome 5 (human)
End · 2
Integrin alpha 2 → 115,068,636 bp, 53,094,779 bp
Aliases · 1
Integrin alpha 2 → ITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2
Available structures · 1
Integrin alpha 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AOX, 1DZI, 1V7P, 4BJ3
BioGPS · 1
Integrin alpha 2 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

integrin α2β1 collagen extracellular receptor itga2 platelets cells gene adhesion cd49b cell matrix expression protein platelet blood binding signaling human

Integrin alpha 2 relationships Subject–Predicate–Object triples

TTTA extracted 162 structured relationships around Integrin alpha 2. Examples in this analysis include Integrin alpha 2 → Aliases → ITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2 and Integrin alpha 2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AOX, 1DZI, 1V7P, 4BJ3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Integrin alpha 2AliasesITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 21.00infobox
Integrin alpha 2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AOX, 1DZI, 1V7P, 4BJ31.00infobox
Integrin alpha 2Band5q11.21.00infobox
Integrin alpha 2Band13 D2.2|13 64.61 cM1.00infobox
Integrin alpha 2Bgeeventricular zone1.00infobox
Integrin alpha 2Bgeeepithelium of nasopharynx1.00infobox
Integrin alpha 2Bgeebronchial epithelial cell1.00infobox
Integrin alpha 2Bgeeislet of Langerhans1.00infobox
Integrin alpha 2Bgeevisceral pleura1.00infobox
Integrin alpha 2Bgeeskin of thigh1.00infobox
Integrin alpha 2Bgeeskin of hip1.00infobox
Integrin alpha 2Bgeegingival epithelium1.00infobox
Integrin alpha 2Bgeeseminal vesicula1.00infobox
Integrin alpha 2Bgeevulva1.00infobox
Integrin alpha 2Bgeegastrula1.00infobox
Integrin alpha 2Bgeecumulus cell1.00infobox
Integrin alpha 2Bgeelumbar spinal ganglion1.00infobox
Integrin alpha 2Bgeemolar1.00infobox
Integrin alpha 2Bgeeblood1.00infobox
Integrin alpha 2Bgeetrigeminal ganglion1.00infobox
Integrin alpha 2BgeePaneth cell1.00infobox
Integrin alpha 2Bgeedecidua1.00infobox
Integrin alpha 2Bgeeleft lung lobe1.00infobox
Integrin alpha 2Bgeestellate reticulum1.00infobox
Integrin alpha 2BioGPSn/a1.00infobox
Integrin alpha 2Chr.Chromosome 5 (human)1.00infobox
Integrin alpha 2Chr.Chromosome 13 (mouse)1.00infobox
Integrin alpha 2DatabasesNCBI: entry; OMA: entry1.00infobox
Integrin alpha 2End53,094,779 bp1.00infobox
Integrin alpha 2End115,068,636 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Integrin alpha 2 bring nearby vocabulary together. In this analysis, examples include Α2β1, Collagen and Extracellular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Integrin alpha 2
    • Α2β1
    • Collagen
    • Extracellular
    • Adhesion
    • Human
    • Matrix
    • Cd49b
    • Signaling
    • Platelet
    • Alpha
    • Functions
    • Integrin
  • integrin alpha 2
    • Α2β1
    • Subunit
    • Collagen
    • Extracellular
    • Adhesion
    • Human
    • Matrix
    • Cd49b
    • Signaling
    • Platelet
    • Alpha
    • Functions
  • protein
    • Chromosome
    • Itga2
    • Migration
    • Binding
    • Expression
    • Matrix
    • Adhesion
    • Mouse
    • Band
    • Extracellular
    • Bp
    • Chr
  • gene
    • Itga2
    • Chromosome
    • Human
    • Protein
    • Expression
    • Bp
    • Chr
    • Mouse
    • Cell
    • Band
    • Receptor
    • Development
  • integrin
    • Α2β1
    • Collagen
    • Extracellular
    • Adhesion
    • Matrix
    • Signaling
    • Platelet
    • Alpha
    • Functions
    • Protein
    • Cells
    • Intracellular
  • cell adhesion
    • Migration
    • Platelet
    • Hemostasis
    • Collagen
    • Receptor
    • Signaling
    • Intracellular
    • Integrin
    • Involved
    • Process
    • Α2β1
    • Development
  • collagen
    • Α2β1
    • Platelet
    • Integrin
    • Blood
    • Platelets
    • Receptors
    • Signaling
    • Matrix
    • Binding
    • Hemostasis
    • Extracellular
    • Receptor
  • cell migration
    • Migration
    • Process
    • Receptor
    • Signaling
    • Intracellular
    • Protein
    • Gene
    • Adhesion
    • Involved
    • Types
    • Human
    • Matrix

Connections between topic areas Semantic bridges

For Integrin alpha 2, one of the stronger structural bridges in this analysis connects Integrin alpha 2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Integrin alpha 2Clinical significance · splits 82 ⟂ 30
Integrin alpha 2Biological functions · splits 90 ⟂ 22
Integrin alpha 2Immune function · splits 95 ⟂ 17
Integrin alpha 2Overview · splits 98 ⟂ 14
Integrin alpha 2Structure · splits 98 ⟂ 14
Integrin alpha 2Ligands · splits 101 ⟂ 11
Integrin alpha 2Interactions · splits 109 ⟂ 3

Map overview Semantic statistics

Integrin alpha 2

Nodes112
Edges111
Triples162
Avg. degree1.98
Density0.017857
Components1

Source & methodology

TTTA analyzes the structure around Integrin alpha 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Biological functions, Clinical significance & Immune function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Integrin alpha 2 · EN edition · Analysis: TopicsToTalkAbout

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