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Membrane cofactor protein

Membrane cofactor protein (MCP), CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) is a protein which in humans is encoded by the CD46 gene. CD46 is an inhibitory complement receptor.

Clinical significance, Function & Interactions

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Clinical significance

7 related topics

Function

5 related topics

Interactions

4 related topics

Gene

1 related topics

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Aliases
CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8
Band
1q32.2 · 1 H6|1 98.41 cM
Bgee
palpebral conjunctiva · seminal vesicula · bronchial epithelial cell · jejunal mucosa · germinal epithelium
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Gene

Function

Clinical significance

Interactions

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Membrane cofactor protein

Nodes27
Edges26
Triples120
Avg. degree1.93
Density0.074074
Components1

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Membrane cofactor protein

Top relations

Gene ontology · 42
Membrane cofactor protein → acrosomal vesicle, adaptive immune response, basolateral plasma membrane, cadherin binding, cell surface, complement activation, classical pathway, complement binding, cytoplasm, cytoplasmic vesicle, endopeptidase activity, enzyme inhibitor activity, extracellular exosome, focal adhesion, Golgi apparatus, immune system process, innate immune response, inner acrosomal membrane, integral component of membrane, integral component of plasma membrane, interleukin-10 production
Bgee · 20
Membrane cofactor protein → body of pancreas, bronchial epithelial cell, embryo, germinal epithelium, granulocyte, intestinal villus, jejunal mucosa, lumbar subsegment of spinal cord, muscle of thigh, palpebral conjunctiva, parotid gland, placenta, primary visual cortex, right lung, right uterine tube, seminal vesicula, seminiferous tubule, spermatid, vastus lateralis muscle, ventricular zone
RNA expression pattern · 20
Membrane cofactor protein → body of pancreas, bronchial epithelial cell, embryo, germinal epithelium, granulocyte, intestinal villus, jejunal mucosa, lumbar subsegment of spinal cord, muscle of thigh, palpebral conjunctiva, parotid gland, placenta, primary visual cortex, right lung, right uterine tube, seminal vesicula, seminiferous tubule, spermatid, vastus lateralis muscle, ventricular zone
related to External links · 15
Membrane cofactor protein → Atypical Hemolytic-Uremic SyndromeCD46, Atypical Hemolytic-Uremic SyndromeOMIM, CD46, GeneReviews/NCBI/NIH/UW, Human CD46, Human Membrane, Medicine Medical Subject Headings, MeSH, National Library, Overview, P15529, PDB, PDBe-KB, UCSC Genome Browser, UniProt
Band · 2
Membrane cofactor protein → 1 H6|1 98.41 cM, 1q32.2
Chr. · 2
Membrane cofactor protein → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
Membrane cofactor protein → 194,774,557 bp, 207,795,513 bp
Aliases · 1
Membrane cofactor protein → CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule
Available structures · 1
Membrane cofactor protein → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8
BioGPS · 1
Membrane cofactor protein → More reference expression data

Important terminology Word statistics

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Important terminology

cd46 gene human protein bp complement chr band chromosome encoded membrane receptor location binding regulatory medulloblastoma hhv-6 cofactor entry measles

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Membrane cofactor proteinAliasesCD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule1.00infobox
Membrane cofactor proteinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO81.00infobox
Membrane cofactor proteinBand1q32.21.00infobox
Membrane cofactor proteinBand1 H6|1 98.41 cM1.00infobox
Membrane cofactor proteinBgeepalpebral conjunctiva1.00infobox
Membrane cofactor proteinBgeeseminal vesicula1.00infobox
Membrane cofactor proteinBgeebronchial epithelial cell1.00infobox
Membrane cofactor proteinBgeejejunal mucosa1.00infobox
Membrane cofactor proteinBgeegerminal epithelium1.00infobox
Membrane cofactor proteinBgeeparotid gland1.00infobox
Membrane cofactor proteinBgeeplacenta1.00infobox
Membrane cofactor proteinBgeeright uterine tube1.00infobox
Membrane cofactor proteinBgeeright lung1.00infobox
Membrane cofactor proteinBgeebody of pancreas1.00infobox
Membrane cofactor proteinBgeeseminiferous tubule1.00infobox
Membrane cofactor proteinBgeespermatid1.00infobox
Membrane cofactor proteinBgeegranulocyte1.00infobox
Membrane cofactor proteinBgeevastus lateralis muscle1.00infobox
Membrane cofactor proteinBgeeintestinal villus1.00infobox
Membrane cofactor proteinBgeeprimary visual cortex1.00infobox
Membrane cofactor proteinBgeelumbar subsegment of spinal cord1.00infobox
Membrane cofactor proteinBgeemuscle of thigh1.00infobox
Membrane cofactor proteinBgeeventricular zone1.00infobox
Membrane cofactor proteinBgeeembryo1.00infobox
Membrane cofactor proteinBioGPSMore reference expression data1.00infobox
Membrane cofactor proteinChr.Chromosome 1 (human)1.00infobox
Membrane cofactor proteinChr.Chromosome 1 (mouse)1.00infobox
Membrane cofactor proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Membrane cofactor proteinEnd207,795,513 bp1.00infobox
Membrane cofactor proteinEnd194,774,557 bp1.00infobox

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