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Integrin alpha-1

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.

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1 related topics

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Aliases
ITGA1, CD49a, VLA1, integrin subunit alpha 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PT6, 1QC5, 1QCY, 2L8S, 4A0Q, 2M32
Band
5q11.2 · 13 D2.2|13 64.61 cM
Bgee
Achilles tendon · gastric mucosa · right coronary artery · stromal cell of endometrium · epithelium of colon
BioGPS
n/a
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)

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Integrin alpha-1

Nodes3
Edges2
Triples161
Avg. degree1.33
Density0.666667
Components1

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Integrin alpha-1

Top relations

Gene ontology · 34
Integrin alpha-1 → acrosomal vesicle, basal part of cell, cell adhesion, cell chemotaxis, cell surface, cell-matrix adhesion, cellular extravasation, collagen binding, collagen binding involved in cell-matrix adhesion, external side of plasma membrane, extracellular exosome, extracellular matrix organization, focal adhesion, integral component of membrane, integrin alpha1-beta1 complex, integrin complex, integrin-mediated signaling pathway, membrane, membrane raft, metal ion binding
Bgee · 19
Integrin alpha-1 → Achilles tendon, aorta, ascending aorta, brown adipose tissue, decidua, epithelium of colon, gastric mucosa, left coronary artery, left lung lobe, popliteal artery, right coronary artery, right lung, right lung lobe, saphenous vein, sciatic nerve, stromal cell of endometrium, tibial arteries, umbilical cord, vas deferens
RNA expression pattern · 19
Integrin alpha-1 → Achilles tendon, aorta, ascending aorta, brown adipose tissue, decidua, epithelium of colon, gastric mucosa, left coronary artery, left lung lobe, popliteal artery, right coronary artery, right lung, right lung lobe, saphenous vein, sciatic nerve, stromal cell of endometrium, tibial arteries, umbilical cord, vas deferens
related to Regulation of cell adhesion, migration, and survival · 16
Integrin alpha-1 → A-Actinin, ALDH1-high, ECM, In Pancreatic Ductal Adenocarcinoma, In PDAC, Integrin, ITGA1, Kindlin, Loss, Paxillin, PDAC, Reduction, Talin, The, This, Vinculin
related to External links · 12
Integrin alpha-1 → CD49a, Cell Migration Gateway Archived, Human Integrin, Human ITGA1, ITGA1, ITGA1 Info, Medicine Medical Subject Headings, MeSH, National Library, PDB, UCSC Genome Browser, Wayback MachinePDBe-KB
related to Structure · 9
Integrin alpha-1 → Beta-1, ECM, Gene Ontology, GRCh38, Integrin, ITGA1, The, The ITGA1, Willebrand
related to Extracellular matrix adhesion and signaling · 8
Integrin alpha-1 → By, ECM, ECM-dependent, Integrin, ITGA1, ITGB1, The, These
Band · 2
Integrin alpha-1 → 13 D2.2|13 64.61 cM, 5q11.2
Chr. · 2
Integrin alpha-1 → Chromosome 13 (mouse), Chromosome 5 (human)
End · 2
Integrin alpha-1 → 115,238,500 bp, 52,959,209 bp

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Important terminology

itga1 cells signaling cell expression tumor integrin adhesion migration resistance ecm progression tissue survival pdac increased pathways cd49a human immune

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Integrin alpha-1AliasesITGA1, CD49a, VLA1, integrin subunit alpha 11.00infobox
Integrin alpha-1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PT6, 1QC5, 1QCY, 2L8S, 4A0Q, 2M321.00infobox
Integrin alpha-1Band5q11.21.00infobox
Integrin alpha-1Band13 D2.2|13 64.61 cM1.00infobox
Integrin alpha-1BgeeAchilles tendon1.00infobox
Integrin alpha-1Bgeegastric mucosa1.00infobox
Integrin alpha-1Bgeeright coronary artery1.00infobox
Integrin alpha-1Bgeestromal cell of endometrium1.00infobox
Integrin alpha-1Bgeeepithelium of colon1.00infobox
Integrin alpha-1Bgeesaphenous vein1.00infobox
Integrin alpha-1Bgeeright lung1.00infobox
Integrin alpha-1Bgeepopliteal artery1.00infobox
Integrin alpha-1Bgeetibial arteries1.00infobox
Integrin alpha-1Bgeeleft coronary artery1.00infobox
Integrin alpha-1Bgeeright lung lobe1.00infobox
Integrin alpha-1Bgeeumbilical cord1.00infobox
Integrin alpha-1Bgeeaorta1.00infobox
Integrin alpha-1Bgeeleft lung lobe1.00infobox
Integrin alpha-1Bgeeascending aorta1.00infobox
Integrin alpha-1Bgeesciatic nerve1.00infobox
Integrin alpha-1Bgeebrown adipose tissue1.00infobox
Integrin alpha-1Bgeevas deferens1.00infobox
Integrin alpha-1Bgeedecidua1.00infobox
Integrin alpha-1BioGPSn/a1.00infobox
Integrin alpha-1Chr.Chromosome 5 (human)1.00infobox
Integrin alpha-1Chr.Chromosome 13 (mouse)1.00infobox
Integrin alpha-1DatabasesNCBI: entry; OMA: entry1.00infobox
Integrin alpha-1End52,959,209 bp1.00infobox
Integrin alpha-1End115,238,500 bp1.00infobox
Integrin alpha-1EnsemblENSG000002139491.00infobox

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