Glyceraldehyde 3-phosphate dehydrogenase

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Glyceraldehyde 3-phosphate dehydrogenase topic overview

The analysis highlights Applications, Function and Interactions as prominent areas in the source structure around Glyceraldehyde 3-phosphate dehydrogenase.

Related topics: 138
Source areas: 8
Connected nodes: 146
Extracted relationships: 89
Concept neighborhoods: 33
Bridge connections: 146

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 37 topics

Function · 36 topics

Overview · 21 topics

Clinical significance · 18 topics

Reaction · 10 topics

Structure · 9 topics

Use as loading control · 5 topics

Cellular distribution · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.2.1.12: ↗
Aliases: GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI
Band: 12p13.31
Bgee: frontal pole · pons · paraflocculus of cerebellum · Brodmann area 10 · triceps brachii muscle
BioGPS: n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Cytoplasmic Cytoplasm
Tetramer
KDa
Isoelectric point
Residue Amino acid
Active site
Oxidative stress
Post-translational modifications Post-translational modification
Spermatozoa

Reaction

Function

Glycerate 1,3-bisphosphate
Cytosol
Moonlighting functions Protein moonlighting
Mycoplasma
Streptococcus
Paracoccidioides brasiliensis
Candida albicans
Fibronectin
Laminin
Probiotics Probiotic
Mucin
Lactobacillus acidophilus
Lactate dehydrogenase
Metabolism
Nucleus Cell nucleus
DNA
S-nitrosylated Nitric oxide
SIAH1
Ubiquitin ligase
Degradation Protein degradation
Deprenyl
Parkinson's disease
Oxidants Oxidant
NADPH
Pentose phosphate pathway
Glutaredoxin
Thioredoxin
Gluthathione
Vesicle transport Vesicle (biology)
Endoplasmic reticulum
Golgi apparatus
Rab2 Rab (G-protein)
Vesicular-tubular clusters
Tyrosine
Src Src (gene)
Chaperone protein Chaperone (protein)

Use as loading control

Housekeeping gene
Loading control Western blot normalization
Western blot
QPCR
MZF-1 MZF1

Cellular distribution

Clinical significance

Interactions

Protein–protein interactions
Tubulin
Actin
VDAC1
Mitochondrial Mitochondria
Membrane permeabilization Membrane permeability
Ca2+
Signaling Signal transduction
Oct-1
Coactivator
Complex Protein complex
Histone H2B
S phase
Cell cycle
P22 P22 (protein)?action=edit&redlink=1
Microtubule
Transferrin
APE1 APEX1
Endonuclease
Promyelocytic leukaemia protein Promyelocytic leukemia protein
RNA
Rheb
GTPase
Ubiquitinates Ubiquitin
CREB binding protein CREB-binding protein
Acetylates Acetylate
Akt
GAPDH
Hepatitis A
Hepatitis B
Hepatitis C
Lymphokine
IFN-γ
JEV
Desmethylselegiline
Koningic acid
Selegiline

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Glyceraldehyde 3-phosphate dehydrogenase connects Entity context

The extracted context around Glyceraldehyde 3-phosphate dehydrogenase shows recurring relationship patterns in the source. For example, Glyceraldehyde 3-phosphate dehydrogenase → antimicrobial humoral immune response mediated by antimicrobial peptide, apoptotic process, aspartic-type endopeptidase inhibitor activity, canonical glycolysis, cellular response to interferon-gamma, cytoplasm, cytoskeleton, cytosol, disordered domain specific binding, extracellular exosome, extracellular matrix, GAIT complex, gluconeogenesis, glucose metabolic process, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, glycolytic process, identical protein binding, intracellular membrane-bounded organelle, lipid droplet, membrane Another extracted example is Glyceraldehyde 3-phosphate dehydrogenase → body of tongue, Brodmann area 10, Brodmann area 46, deltoid muscle, frontal pole, lateral nuclear group of thalamus, paraflocculus of cerebellum, pons, Skeletal muscle tissue of biceps brachii, triceps brachii muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 43

Glyceraldehyde 3-phosphate dehydrogenase → antimicrobial humoral immune response mediated by antimicrobial peptide, apoptotic process, aspartic-type endopeptidase inhibitor activity, canonical glycolysis, cellular response to interferon-gamma, cytoplasm, cytoskeleton, cytosol, disordered domain specific binding, extracellular exosome, extracellular matrix, GAIT complex, gluconeogenesis, glucose metabolic process, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, glycolytic process, identical protein binding, intracellular membrane-bounded organelle, lipid droplet, membrane

Bgee · 10

Glyceraldehyde 3-phosphate dehydrogenase → body of tongue, Brodmann area 10, Brodmann area 46, deltoid muscle, frontal pole, lateral nuclear group of thalamus, paraflocculus of cerebellum, pons, Skeletal muscle tissue of biceps brachii, triceps brachii muscle

RNA expression pattern · 10

related to Metabolic · 5

Glyceraldehyde 3-phosphate dehydrogenase → As, D-glycerate, GAPDH, The, This

1.2.1.12 · 1

Glyceraldehyde 3-phosphate dehydrogenase → ↗

Aliases · 1

Glyceraldehyde 3-phosphate dehydrogenase → GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase

Available structures · 1

Glyceraldehyde 3-phosphate dehydrogenase → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI

Band · 1

Glyceraldehyde 3-phosphate dehydrogenase → 12p13.31

BioGPS · 1

Glyceraldehyde 3-phosphate dehydrogenase → n/a

Chr. · 1

Glyceraldehyde 3-phosphate dehydrogenase → Chromosome 12 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gapdh glycolysis function human protein transcription apoptosis dehydrogenase reaction pathway cellular metabolic phosphorylation cells step energy gene functions 12 binding

Glyceraldehyde 3-phosphate dehydrogenase relationships Subject–Predicate–Object triples

TTTA extracted 89 structured relationships around Glyceraldehyde 3-phosphate dehydrogenase. Examples in this analysis include Glyceraldehyde 3-phosphate dehydrogenase → 1.2.1.12 → ↗ and Glyceraldehyde 3-phosphate dehydrogenase → Aliases → GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Glyceraldehyde 3-phosphate dehydrogenase	1.2.1.12	↗	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Aliases	GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Band	12p13.31	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	frontal pole	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	pons	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	paraflocculus of cerebellum	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	Brodmann area 10	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	triceps brachii muscle	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	deltoid muscle	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	Skeletal muscle tissue of biceps brachii	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	Brodmann area 46	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	lateral nuclear group of thalamus	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	body of tongue	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	BioGPS	n/a	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Chr.	Chromosome 12 (human)	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Databases	NCBI: entry; OMA: entry	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	End	6,538,374 bp	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Ensembl	ENSG00000111640	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Entrez	2597	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Enzyme activity	Enzyme activityEC #BRENDAExPASyKEGGMetaCyc1.2.1.12↗↗↗↗	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	External IDs	OMIM: 138400; MGI: 5434255; GeneCards: GAPDH	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene location (Human)	Gene location (Human)Chr.Chromosome 12 (human)Band12p13.31Start6,534,512 bpEnd6,538,374 bp	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	transferase activity	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	microtubule binding	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	NAD binding	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	protein binding	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	peptidyl-cysteine S-nitrosylase activity	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	NADP binding	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Glyceraldehyde 3-phosphate dehydrogenase bring nearby vocabulary together. In this analysis, examples include Complex, Glucose and Binding. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Glyceraldehyde 3-phosphate dehydrogenase
- Complex
- Glucose
- Binding
- Human
- Bp
- Protein
- Nucleus
- Interactions
- Membrane
- Transport
- Apoptosis
- Cellular
glyceraldehyde 3-phosphate dehydrogenase
- Complex
- Glucose
- Binding
- Human
- Bp
- Protein
- Nucleus
- Interactions
- Membrane
- Transport
- Apoptosis
- Cellular
glycolysis
- Cytosol
- Glucose
- Cellular
- Metabolic
- Step
- Reaction
- Bp
- Complex
- Nucleus
- Acid
- Expressed
- Glycolytic
glucose
- Glycolytic
- Complex
- Nucleus
- Cytosol
- Membrane
- Binding
- Nuclear
- Thus
- Glycolysis
- Step
- Cells
- Protein
apoptosis
- Transport
- Interactions
- Function
- Protein
- Membrane
- Binding
- Metabolic
- Nuclear
- Stress
- Transcription
- Dehydrogenase
- Functions
axoplasmic transport
- Apoptosis
- Interactions
- Function
- Protein
- Membrane
- Binding
- Metabolic
- Nuclear
- Transcription
- Dehydrogenase
- Functions
- Proteins
carboxylic acid
- Reaction
- Binding
- Phosphorylation
- Bp
- Adhesion
- Interactions
- Kegg
- Transport
- Apoptosis
- Cellular
- Metabolic
- Transcription
moonlighting functions
- Interactions
- Binding
- Transport
- Cells
- Protein
- Bp
- Gapdh
- Complex
- Nucleus
- Acid
- Glucose
- Glycolytic

Connections between topic areas Semantic bridges

For Glyceraldehyde 3-phosphate dehydrogenase, one of the stronger structural bridges in this analysis connects Glyceraldehyde 3-phosphate dehydrogenase with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Glyceraldehyde 3-phosphate dehydrogenase — Interactions · splits 109 ⟂ 38

Glyceraldehyde 3-phosphate dehydrogenase — Function · splits 110 ⟂ 37

Glyceraldehyde 3-phosphate dehydrogenase — Overview · splits 125 ⟂ 22

Glyceraldehyde 3-phosphate dehydrogenase — Clinical significance · splits 128 ⟂ 19

Glyceraldehyde 3-phosphate dehydrogenase — Reaction · splits 136 ⟂ 11

Glyceraldehyde 3-phosphate dehydrogenase — Structure · splits 137 ⟂ 10

Glyceraldehyde 3-phosphate dehydrogenase — Use as loading control · splits 141 ⟂ 6

Glyceraldehyde 3-phosphate dehydrogenase — Cellular distribution · splits 144 ⟂ 3

Map overview Semantic statistics

Glyceraldehyde 3-phosphate dehydrogenase

Nodes147

Edges146

Triples89

Avg. degree1.99

Density0.013605

Components1

Source & methodology

TTTA analyzes the structure around Glyceraldehyde 3-phosphate dehydrogenase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Glyceraldehyde 3-phosphate dehydrogenase · EN edition · Analysis: TopicsToTalkAbout