Glyceraldehyde 3-phosphate dehydrogenase

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Explore the main themes, entities and connections around Glyceraldehyde 3-phosphate dehydrogenase. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Glycerate 1,3-bisphosphate Cytosol Moonlighting functions Mycoplasma Streptococcus

36 related topics

Interactions

Protein–protein interactions Tubulin Actin VDAC1 Mitochondrial

37 related topics

Clinical significance

Melanoma Tumorigenesis Telomere Chemotherapeutic Sphingolipid

18 related topics

Overview

EC Enzyme KDa Glycolysis Glucose

21 related topics

Key facts & relationships

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1.2.1.12: ↗
Aliases: GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI
Band: 12p13.31
Bgee: frontal pole · pons · paraflocculus of cerebellum · Brodmann area 10 · triceps brachii muscle
BioGPS: n/a

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Overview

Structure

Cytoplasmic Cytoplasm
Tetramer
KDa
Isoelectric point
Residue Amino acid
Active site
Oxidative stress
Post-translational modifications Post-translational modification
Spermatozoa

Reaction

Function

Glycerate 1,3-bisphosphate
Cytosol
Moonlighting functions Protein moonlighting
Mycoplasma
Streptococcus
Paracoccidioides brasiliensis
Candida albicans
Fibronectin
Laminin
Probiotics Probiotic
Mucin
Lactobacillus acidophilus
Lactate dehydrogenase
Metabolism
Nucleus Cell nucleus
DNA
S-nitrosylated Nitric oxide
SIAH1
Ubiquitin ligase
Degradation Protein degradation
Deprenyl
Parkinson's disease
Oxidants Oxidant
NADPH
Pentose phosphate pathway
Glutaredoxin
Thioredoxin
Gluthathione
Vesicle transport Vesicle (biology)
Endoplasmic reticulum

Use as loading control

Housekeeping gene
Loading control Western blot normalization
Western blot
QPCR
MZF-1 MZF1

Cellular distribution

Clinical significance

Interactions

Protein–protein interactions
Tubulin
Actin
VDAC1
Mitochondrial Mitochondria
Membrane permeabilization Membrane permeability
Ca2+
Signaling Signal transduction
Oct-1
Coactivator
Complex Protein complex
Histone H2B
S phase
Cell cycle
P22 P22 (protein)?action=edit&redlink=1
Microtubule
Transferrin
APE1 APEX1
Endonuclease
Promyelocytic leukaemia protein Promyelocytic leukemia protein
RNA
Rheb
GTPase
Ubiquitinates Ubiquitin
CREB binding protein CREB-binding protein
Acetylates Acetylate
Akt
GAPDH
Hepatitis A
Hepatitis B

Advanced semantic analysis

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Map overview Semantic statistics

Nodes147

Edges146

Triples89

Avg. degree1.99

Density0.013605

Components1

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Glyceraldehyde 3-phosphate dehydrogenase

Top relations

Gene ontology · 43

Glyceraldehyde 3-phosphate dehydrogenase → antimicrobial humoral immune response mediated by antimicrobial peptide, apoptotic process, aspartic-type endopeptidase inhibitor activity, canonical glycolysis, cellular response to interferon-gamma, cytoplasm, cytoskeleton, cytosol, disordered domain specific binding, extracellular exosome, extracellular matrix, GAIT complex, gluconeogenesis, glucose metabolic process, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, glycolytic process, identical protein binding, intracellular membrane-bounded organelle, lipid droplet, membrane

Bgee · 10

Glyceraldehyde 3-phosphate dehydrogenase → body of tongue, Brodmann area 10, Brodmann area 46, deltoid muscle, frontal pole, lateral nuclear group of thalamus, paraflocculus of cerebellum, pons, Skeletal muscle tissue of biceps brachii, triceps brachii muscle

RNA expression pattern · 10

related to Metabolic · 5

Glyceraldehyde 3-phosphate dehydrogenase → As, D-glycerate, GAPDH, The, This

1.2.1.12 · 1

Glyceraldehyde 3-phosphate dehydrogenase → ↗

Aliases · 1

Glyceraldehyde 3-phosphate dehydrogenase → GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase

Available structures · 1

Glyceraldehyde 3-phosphate dehydrogenase → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI

Band · 1

Glyceraldehyde 3-phosphate dehydrogenase → 12p13.31

BioGPS · 1

Glyceraldehyde 3-phosphate dehydrogenase → n/a

Chr. · 1

Glyceraldehyde 3-phosphate dehydrogenase → Chromosome 12 (human)

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gapdh glycolysis function human protein transcription apoptosis dehydrogenase reaction pathway cellular metabolic phosphorylation cells step energy gene functions 12 binding

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Glyceraldehyde 3-phosphate dehydrogenase	1.2.1.12	↗	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Aliases	GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Band	12p13.31	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	frontal pole	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	pons	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	paraflocculus of cerebellum	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	Brodmann area 10	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	triceps brachii muscle	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	deltoid muscle	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	Skeletal muscle tissue of biceps brachii	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	Brodmann area 46	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	lateral nuclear group of thalamus	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Bgee	body of tongue	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	BioGPS	n/a	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Chr.	Chromosome 12 (human)	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Databases	NCBI: entry; OMA: entry	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	End	6,538,374 bp	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Ensembl	ENSG00000111640	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Entrez	2597	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Enzyme activity	Enzyme activityEC #BRENDAExPASyKEGGMetaCyc1.2.1.12↗↗↗↗	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	External IDs	OMIM: 138400; MGI: 5434255; GeneCards: GAPDH	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene location (Human)	Gene location (Human)Chr.Chromosome 12 (human)Band12p13.31Start6,534,512 bpEnd6,538,374 bp	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	transferase activity	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	microtubule binding	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	NAD binding	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	protein binding	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	peptidyl-cysteine S-nitrosylase activity	1.00	infobox
Glyceraldehyde 3-phosphate dehydrogenase	Gene ontology	NADP binding	1.00	infobox

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