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Thioredoxin: Interactions, Effect on cardiac hypertrophy & Function

Thioredoxin (TRX or TXN) is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN and TXN2 genes. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at the four-cell stage of the…

Language: English [EN]
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Thioredoxin topic overview

The analysis highlights Interactions, Effect on cardiac hypertrophy and Function as prominent areas in the source structure around Thioredoxin.

Related topics
49
Source areas
6
Connected nodes
55
Extracted relationships
146
Concept neighborhoods
18
Bridge connections
55

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 13 topics
Effect on cardiac hypertrophy · 11 topics
Overview · 11 topics
Function · 7 topics
Structure and mechanism · 6 topics
Occurrence · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TXN, TRDX, TRX, TRX1, thioredoxin, Trx80
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TRX, 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK,…
Band
9q31.3 · 4 B3|4 31.87 cM
Bgee
gingival epithelium · mucosa of pharynx · oral cavity · epithelium of nasopharynx · mucosa of sigmoid colon
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 4 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Occurrence

Function

Structure and mechanism

Interactions

Effect on cardiac hypertrophy

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Thioredoxin connects Entity context

The extracted context around Thioredoxin shows recurring relationship patterns in the source. For example, Thioredoxin → activation of protein kinase B activity, cell population proliferation, cell redox homeostasis, cell-cell signaling, cellular oxidant detoxification, cellular response to oxidative stress, cytoplasm, cytosol, extracellular exosome, extracellular region, glycerol ether metabolic process, mitochondrion, negative regulation of hydrogen peroxide-induced cell death, negative regulation of protein export from nucleus, negative regulation of transcription by RNA polymerase II, nucleobase-containing small molecule interconversion, nucleoplasm, nucleus, oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor, positive regulation of DNA binding Another extracted example is Thioredoxin → body of tongue, colon, duodenum, epithelium of nasopharynx, esophagus, gingival epithelium, granulocyte, human penis, ileum, jejunum, mucosa of esophagus, mucosa of pharynx, mucosa of sigmoid colon, mucosa of transverse colon, nasal epithelium, oral cavity, proximal tubule, right kidney, synovial joint, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Thioredoxin

Top relations

Gene ontology · 32
Thioredoxin → activation of protein kinase B activity, cell population proliferation, cell redox homeostasis, cell-cell signaling, cellular oxidant detoxification, cellular response to oxidative stress, cytoplasm, cytosol, extracellular exosome, extracellular region, glycerol ether metabolic process, mitochondrion, negative regulation of hydrogen peroxide-induced cell death, negative regulation of protein export from nucleus, negative regulation of transcription by RNA polymerase II, nucleobase-containing small molecule interconversion, nucleoplasm, nucleus, oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor, positive regulation of DNA binding
Bgee · 20
Thioredoxin → body of tongue, colon, duodenum, epithelium of nasopharynx, esophagus, gingival epithelium, granulocyte, human penis, ileum, jejunum, mucosa of esophagus, mucosa of pharynx, mucosa of sigmoid colon, mucosa of transverse colon, nasal epithelium, oral cavity, proximal tubule, right kidney, synovial joint, thymus
RNA expression pattern · 20
Thioredoxin → body of tongue, colon, duodenum, epithelium of nasopharynx, esophagus, gingival epithelium, granulocyte, human penis, ileum, jejunum, mucosa of esophagus, mucosa of pharynx, mucosa of sigmoid colon, mucosa of transverse colon, nasal epithelium, oral cavity, proximal tubule, right kidney, synovial joint, thymus
related to Interactions · 14
Thioredoxin → AMPK, AP1, ASK1, By, Collagen, DNA, DNA-binding, Glucocorticoid, NF-κB, Ref-1, Ref1, SENP1, Trx1, TXNIP
related to Structure and mechanism · 11
Thioredoxin → Almost, CXXC, Cys, Cys32, Cys35, For Trx1, NADPH, Oxidized Trx1, The, These, Trx1
related to Thioredoxin-like proteins · 10
Thioredoxin → CVQC, DNA, Mycobacterium, NrdH, NrdH's, Structural, This, TrxR, Unlike, WSGFRP
related to External links · 8
Thioredoxin → Medicine Medical Subject Headings, MeSH, National Library, Overview, P10599, PDB, PDBe-KB, UniProt
related to Function · 6
Thioredoxin → Multiple, NADPH-dependent, Reduction, The, Thioredoxins, Trx
Band · 2
Thioredoxin → 4 B3|4 31.87 cM, 9q31.3
Chr. · 2
Thioredoxin → Chromosome 4 (mouse), Chromosome 9 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

trx1 thioredoxins human redox bp activity protein proteins txn reductase chr band function cardiac role chromosome also disulfide trx oxidized

Thioredoxin relationships Subject–Predicate–Object triples

TTTA extracted 146 structured relationships around Thioredoxin. Examples in this analysis include Thioredoxin → Aliases → TXN, TRDX, TRX, TRX1, thioredoxin, Trx80 and Thioredoxin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TRX, 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ThioredoxinAliasesTXN, TRDX, TRX, TRX1, thioredoxin, Trx801.00infobox
ThioredoxinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TRX, 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK,…1.00infobox
ThioredoxinBand9q31.31.00infobox
ThioredoxinBand4 B3|4 31.87 cM1.00infobox
ThioredoxinBgeegingival epithelium1.00infobox
ThioredoxinBgeemucosa of pharynx1.00infobox
ThioredoxinBgeeoral cavity1.00infobox
ThioredoxinBgeeepithelium of nasopharynx1.00infobox
ThioredoxinBgeemucosa of sigmoid colon1.00infobox
ThioredoxinBgeemucosa of esophagus1.00infobox
ThioredoxinBgeemucosa of transverse colon1.00infobox
ThioredoxinBgeehuman penis1.00infobox
ThioredoxinBgeebody of tongue1.00infobox
ThioredoxinBgeenasal epithelium1.00infobox
ThioredoxinBgeejejunum1.00infobox
ThioredoxinBgeeileum1.00infobox
ThioredoxinBgeecolon1.00infobox
ThioredoxinBgeegranulocyte1.00infobox
ThioredoxinBgeeduodenum1.00infobox
ThioredoxinBgeeproximal tubule1.00infobox
ThioredoxinBgeesynovial joint1.00infobox
ThioredoxinBgeethymus1.00infobox
ThioredoxinBgeeesophagus1.00infobox
ThioredoxinBgeeright kidney1.00infobox
ThioredoxinBioGPSMore reference expression data1.00infobox
ThioredoxinChr.Chromosome 9 (human)1.00infobox
ThioredoxinChr.Chromosome 4 (mouse)1.00infobox
ThioredoxinDatabasesNCBI: entry; OMA: entry1.00infobox
ThioredoxinEnd110,256,507 bp1.00infobox
ThioredoxinEnd57,956,411 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Thioredoxin bring nearby vocabulary together. In this analysis, examples include Proteins, Reductase and Structure. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Thioredoxin
    • Proteins
    • Reductase
    • Structure
    • Residues
    • Trx
    • Oxidized
    • Redox
    • Protein
    • Glutaredoxins
    • Trx1
    • Form
    • Two
  • thioredoxin
    • Proteins
    • Reductase
    • Structure
    • Residues
    • Trx
    • Oxidized
    • Redox
    • Protein
    • Glutaredoxins
    • Trx1
    • Form
    • Two
  • redox
    • Binding
    • Signaling
    • Activity
    • Dna
    • Role
    • Txn
    • Protein
    • Mouse
    • Gene
    • Location
    • Nucleus
    • Oxidoreductase
  • thioredoxin reductase
    • Reduced
    • Thioredoxins
    • Glutaredoxins
    • Proteins
    • Reductase
    • Thioredoxin
    • Structure
    • Residues
    • Trx
    • Oxidized
    • Redox
    • Protein
  • thioredoxin fold
    • Proteins
    • Reductase
    • Structure
    • Residues
    • Trx
    • Oxidized
    • Redox
    • Protein
    • Glutaredoxins
    • Trx1
    • Form
    • Two
  • function
    • Disulfide
    • Gene
    • Location
    • Signaling
    • Chromosome
    • Trx
    • Txn
    • Bp
    • Chr
    • Human
    • Oxidized
    • Proteins
  • proteins
    • Structure
    • Trx
    • Two
    • Txn
    • Thioredoxin
    • Also
    • Function
    • Gene
    • Location
    • Plants
    • Signaling
    • Chromosome
  • cardiac hypertrophy
    • Hypertrophy
    • Also
    • Trx
    • Trx1
    • Gene
    • Location
    • Nucleus
    • Protein
    • Structure
    • Txn
    • Reduced
    • Regulate

Connections between topic areas Semantic bridges

For Thioredoxin, one of the stronger structural bridges in this analysis connects Thioredoxin with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ThioredoxinInteractions · splits 42 ⟂ 14
ThioredoxinOverview · splits 44 ⟂ 12
ThioredoxinEffect on cardiac hypertrophy · splits 44 ⟂ 12
ThioredoxinFunction · splits 48 ⟂ 8
ThioredoxinStructure and mechanism · splits 49 ⟂ 7

Map overview Semantic statistics

Thioredoxin

Nodes56
Edges55
Triples146
Avg. degree1.96
Density0.035714
Components1

Source & methodology

TTTA analyzes the structure around Thioredoxin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Effect on cardiac hypertrophy & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Thioredoxin · EN edition · Analysis: TopicsToTalkAbout

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