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Thioredoxin

Thioredoxin (TRX or TXN) is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN and TXN2 genes. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at the four-cell stage of the…

Interactions, Effect on cardiac hypertrophy & Function

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Aliases
TXN, TRDX, TRX, TRX1, thioredoxin, Trx80
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TRX, 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK,…
Band
9q31.3 · 4 B3|4 31.87 cM
Bgee
gingival epithelium · mucosa of pharynx · oral cavity · epithelium of nasopharynx · mucosa of sigmoid colon
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 4 (mouse)

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Overview

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Function

Structure and mechanism

Interactions

Effect on cardiac hypertrophy

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Map overview Semantic statistics

Thioredoxin

Nodes56
Edges55
Triples146
Avg. degree1.96
Density0.035714
Components1

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Thioredoxin

Top relations

Gene ontology · 32
Thioredoxin → activation of protein kinase B activity, cell population proliferation, cell redox homeostasis, cell-cell signaling, cellular oxidant detoxification, cellular response to oxidative stress, cytoplasm, cytosol, extracellular exosome, extracellular region, glycerol ether metabolic process, mitochondrion, negative regulation of hydrogen peroxide-induced cell death, negative regulation of protein export from nucleus, negative regulation of transcription by RNA polymerase II, nucleobase-containing small molecule interconversion, nucleoplasm, nucleus, oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor, positive regulation of DNA binding
Bgee · 20
Thioredoxin → body of tongue, colon, duodenum, epithelium of nasopharynx, esophagus, gingival epithelium, granulocyte, human penis, ileum, jejunum, mucosa of esophagus, mucosa of pharynx, mucosa of sigmoid colon, mucosa of transverse colon, nasal epithelium, oral cavity, proximal tubule, right kidney, synovial joint, thymus
RNA expression pattern · 20
Thioredoxin → body of tongue, colon, duodenum, epithelium of nasopharynx, esophagus, gingival epithelium, granulocyte, human penis, ileum, jejunum, mucosa of esophagus, mucosa of pharynx, mucosa of sigmoid colon, mucosa of transverse colon, nasal epithelium, oral cavity, proximal tubule, right kidney, synovial joint, thymus
related to Interactions · 14
Thioredoxin → AMPK, AP1, ASK1, By, Collagen, DNA, DNA-binding, Glucocorticoid, NF-κB, Ref-1, Ref1, SENP1, Trx1, TXNIP
related to Structure and mechanism · 11
Thioredoxin → Almost, CXXC, Cys, Cys32, Cys35, For Trx1, NADPH, Oxidized Trx1, The, These, Trx1
related to Thioredoxin-like proteins · 10
Thioredoxin → CVQC, DNA, Mycobacterium, NrdH, NrdH's, Structural, This, TrxR, Unlike, WSGFRP
related to External links · 8
Thioredoxin → Medicine Medical Subject Headings, MeSH, National Library, Overview, P10599, PDB, PDBe-KB, UniProt
related to Function · 6
Thioredoxin → Multiple, NADPH-dependent, Reduction, The, Thioredoxins, Trx
Band · 2
Thioredoxin → 4 B3|4 31.87 cM, 9q31.3
Chr. · 2
Thioredoxin → Chromosome 4 (mouse), Chromosome 9 (human)

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Important terminology

trx1 thioredoxins human redox bp activity protein proteins txn reductase chr band function cardiac role chromosome also disulfide trx oxidized

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ThioredoxinAliasesTXN, TRDX, TRX, TRX1, thioredoxin, Trx801.00infobox
ThioredoxinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4TRX, 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK,…1.00infobox
ThioredoxinBand9q31.31.00infobox
ThioredoxinBand4 B3|4 31.87 cM1.00infobox
ThioredoxinBgeegingival epithelium1.00infobox
ThioredoxinBgeemucosa of pharynx1.00infobox
ThioredoxinBgeeoral cavity1.00infobox
ThioredoxinBgeeepithelium of nasopharynx1.00infobox
ThioredoxinBgeemucosa of sigmoid colon1.00infobox
ThioredoxinBgeemucosa of esophagus1.00infobox
ThioredoxinBgeemucosa of transverse colon1.00infobox
ThioredoxinBgeehuman penis1.00infobox
ThioredoxinBgeebody of tongue1.00infobox
ThioredoxinBgeenasal epithelium1.00infobox
ThioredoxinBgeejejunum1.00infobox
ThioredoxinBgeeileum1.00infobox
ThioredoxinBgeecolon1.00infobox
ThioredoxinBgeegranulocyte1.00infobox
ThioredoxinBgeeduodenum1.00infobox
ThioredoxinBgeeproximal tubule1.00infobox
ThioredoxinBgeesynovial joint1.00infobox
ThioredoxinBgeethymus1.00infobox
ThioredoxinBgeeesophagus1.00infobox
ThioredoxinBgeeright kidney1.00infobox
ThioredoxinBioGPSMore reference expression data1.00infobox
ThioredoxinChr.Chromosome 9 (human)1.00infobox
ThioredoxinChr.Chromosome 4 (mouse)1.00infobox
ThioredoxinDatabasesNCBI: entry; OMA: entry1.00infobox
ThioredoxinEnd110,256,507 bp1.00infobox
ThioredoxinEnd57,956,411 bp1.00infobox

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