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NEIL1: Events & Regions

Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.

Language: English [EN]
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NEIL1 topic overview

The analysis highlights Events and Regions as prominent areas in the source structure around NEIL1.

Related topics
29
Source areas
5
Connected nodes
34
Extracted relationships
108
Concept neighborhoods
17
Bridge connections
34

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Deficiency in cancer · 14 topics
Targets · 8 topics
Overview · 5 topics
Memory retention · 1 topics
Stroke prevention · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

4.2.99.18
Aliases
NEIL1, FPG1, NEI1, hFPG1, nei like DNA glycosylase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1TDH, 4NRV, 5ITY, 5ITQ, 5ITU, 5ITX, 5ITR, 5ITT
Band
15q24.2 · 9|9 B
Bgee
right uterine tube · right hemisphere of cerebellum · right adrenal cortex · right frontal lobe · minor salivary glands
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Targets

Deficiency in cancer

Memory retention

Stroke prevention

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NEIL1 connects Entity context

The extracted context around NEIL1 shows recurring relationship patterns in the source. For example, NEIL1 → base-excision repair, catalytic activity, cellular response to DNA damage stimulus, chromosome, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, cytoplasm, cytoskeleton, damaged DNA binding, depyrimidination, DNA binding, DNA N-glycosylase activity, DNA repair, DNA-(apurinic or apyrimidinic site) endonuclease activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing N-glycosyl compounds, lyase activity, metabolism, microtubule organizing center, negative regulation of nuclease activity Another extracted example is NEIL1 → anterior pituitary, brown adipose tissue, canal of the cervix, hand, left adrenal cortex, mesenteric lymph nodes, minor salivary glands, muscle of thigh, otolith organ, proximal tubule, right adrenal cortex, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of liver, right lobe of thyroid gland, right uterine tube, submandibular gland, thymus, utricle. Use these groups to spot repeated connection types before inspecting the individual relationships.

NEIL1

Top relations

Gene ontology · 27
NEIL1 → base-excision repair, catalytic activity, cellular response to DNA damage stimulus, chromosome, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, cytoplasm, cytoskeleton, damaged DNA binding, depyrimidination, DNA binding, DNA N-glycosylase activity, DNA repair, DNA-(apurinic or apyrimidinic site) endonuclease activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing N-glycosyl compounds, lyase activity, metabolism, microtubule organizing center, negative regulation of nuclease activity
Bgee · 20
NEIL1 → anterior pituitary, brown adipose tissue, canal of the cervix, hand, left adrenal cortex, mesenteric lymph nodes, minor salivary glands, muscle of thigh, otolith organ, proximal tubule, right adrenal cortex, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of liver, right lobe of thyroid gland, right uterine tube, submandibular gland, thymus, utricle
RNA expression pattern · 20
NEIL1 → anterior pituitary, brown adipose tissue, canal of the cervix, hand, left adrenal cortex, mesenteric lymph nodes, minor salivary glands, muscle of thigh, otolith organ, proximal tubule, right adrenal cortex, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of liver, right lobe of thyroid gland, right uterine tube, submandibular gland, thymus, utricle
related to Deficiency in cancer · 9
NEIL1 → DNA, HNSCC, MGMT, MLH1, NSCLC, RNA, This, When, While
related to Targets · 6
NEIL1 → Because, DNA, FEN-1, PCNA, ROS-damaged, The
Band · 2
NEIL1 → 15q24.2, 9|9 B
Chr. · 2
NEIL1 → Chromosome 15 (human), Chromosome 9 (mouse)
End · 2
NEIL1 → 57,055,589 bp, 75,357,115 bp
4.2.99.18 · 1
NEIL1 → ↗
Aliases · 1
NEIL1 → NEIL1, FPG1, NEI1, hFPG1, nei like DNA glycosylase 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna repair cancer human bp genes damage chr chromosome band gene 15 also hypermethylated citation needed may deficiency mouse location

NEIL1 relationships Subject–Predicate–Object triples

TTTA extracted 108 structured relationships around NEIL1. Examples in this analysis include NEIL1 → 4.2.99.18 → ↗ and NEIL1 → Aliases → NEIL1, FPG1, NEI1, hFPG1, nei like DNA glycosylase 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NEIL14.2.99.181.00infobox
NEIL1AliasesNEIL1, FPG1, NEI1, hFPG1, nei like DNA glycosylase 11.00infobox
NEIL1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1TDH, 4NRV, 5ITY, 5ITQ, 5ITU, 5ITX, 5ITR, 5ITT1.00infobox
NEIL1Band15q24.21.00infobox
NEIL1Band9|9 B1.00infobox
NEIL1Bgeeright uterine tube1.00infobox
NEIL1Bgeeright hemisphere of cerebellum1.00infobox
NEIL1Bgeeright adrenal cortex1.00infobox
NEIL1Bgeeright frontal lobe1.00infobox
NEIL1Bgeeminor salivary glands1.00infobox
NEIL1Bgeeleft adrenal cortex1.00infobox
NEIL1Bgeecanal of the cervix1.00infobox
NEIL1Bgeeright lobe of liver1.00infobox
NEIL1Bgeeright lobe of thyroid gland1.00infobox
NEIL1Bgeeanterior pituitary1.00infobox
NEIL1Bgeemesenteric lymph nodes1.00infobox
NEIL1Bgeethymus1.00infobox
NEIL1Bgeesubmandibular gland1.00infobox
NEIL1Bgeeotolith organ1.00infobox
NEIL1Bgeeutricle1.00infobox
NEIL1Bgeebrown adipose tissue1.00infobox
NEIL1Bgeehand1.00infobox
NEIL1Bgeeright kidney1.00infobox
NEIL1Bgeeproximal tubule1.00infobox
NEIL1Bgeemuscle of thigh1.00infobox
NEIL1BioGPSMore reference expression data1.00infobox
NEIL1Chr.Chromosome 15 (human)1.00infobox
NEIL1Chr.Chromosome 9 (mouse)1.00infobox
NEIL1DatabasesNCBI: entry; OMA: entry1.00infobox
NEIL1End75,357,115 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NEIL1 bring nearby vocabulary together. In this analysis, examples include Repair, Genes and Hypermethylated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • Activity
    • Mouse
    • Band
    • Class
    • Damaged
    • Lyase
    • Nei
  • dna glycosylases
    • Repair
    • Genes
    • Neil1
    • Cancer
    • Damaged
    • Lyase
    • Nei
    • Species
    • Damage
    • Associated
    • Hypermethylated
    • Promoter
  • base excision repair
    • Genes
    • Cancer
    • Hypermethylated
    • Promoter
    • Citation
    • Needed
    • Neil1
    • Cell
    • Epigenetic
    • Evaluated
    • Expression
    • Region
  • non-small cell lung cancer
    • Expression
    • Region
    • Genes
    • Hypermethylated
    • Promoter
    • Dna
    • Citation
    • Needed
    • Repair
    • May
    • Neil1
    • Activity
  • colorectal cancer
    • Genes
    • Dna
    • Promoter
    • Repair
    • Citation
    • May
    • Needed
    • Neil1
    • Activity
    • Cell
    • Epigenetic
    • Evaluated
  • dna replication
    • Repair
    • Genes
    • Neil1
    • Cancer
    • Damage
    • Hypermethylated
    • Promoter
    • Also
    • Citation
    • May
    • Needed
    • Associated
  • cancer
    • Genes
    • Dna
    • Promoter
    • Repair
    • Citation
    • May
    • Needed
    • Neil1
    • Activity
    • Cell
    • Epigenetic
    • Evaluated
  • deficiency in cancer
    • Genes
    • Dna
    • Promoter
    • Repair
    • Citation
    • May
    • Needed
    • Neil1
    • Activity
    • Cell
    • Epigenetic
    • Evaluated

Connections between topic areas Semantic bridges

For NEIL1, one of the stronger structural bridges in this analysis connects NEIL1 with Deficiency in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NEIL1Deficiency in cancer · splits 20 ⟂ 15
NEIL1Targets · splits 26 ⟂ 9
NEIL1Overview · splits 29 ⟂ 6

Map overview Semantic statistics

NEIL1

Nodes35
Edges34
Triples108
Avg. degree1.94
Density0.057143
Components1

Source & methodology

TTTA analyzes the structure around NEIL1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Events & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NEIL1 · EN edition · Analysis: TopicsToTalkAbout

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