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Down syndrome

Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with developmental delays, mild to moderate intellectual disability, and characteristic physical features.

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Causes
Third copy of chromosome 21
Diagnostic method
Prenatal screening, genetic testing
Duration
Lifelong
Frequency
5.4 million (0.1%)
Named after
John Langdon Down
Other names
Down's syndrome, Down's, trisomy 21

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Overview

Signs and symptoms

Cause

Mechanism

Diagnosis

Management

Prognosis

Epidemiology

History

Society and culture

Research

Other hominids

In popular culture

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Map overview Semantic statistics

Down syndrome

Nodes370
Edges369
Triples440
Avg. degree1.99
Density0.005405
Components1

How this topic connects Entity context

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Down syndrome

Top relations

related to Individuals · 95
Down syndrome → Acting, Activism, Addie, Adelaide, American, American Horror Story, Apocalypse, Atlantic City Fashion Week, Australian, Award, Bachiller, BAFTA-nominated Coming Down, Becky Jackson, Better, Blue Apple Theatre, Brewer, British, British Vogue, Canadian, Canadian Screen Award
related to Television and film · 40
Down syndrome → ABC, American, As, Bobby Farrelly, Born This Way, Bunim/Murray Productions, Burke's, Champions, Charles, Cheech Marin, Chicago, Chris Burke, Corky, Dakota Johnson, Down, Drew, Ernie Hudson, It, James Day Keith, John Hawkes
related to Advocacy groups · 25
Down syndrome → Adults, Advocacy, Before, Down, Down Syndrome International, Down Syndrome International Network, France, Handicapped Children, In, Japan, Judy Fryd, Kathryn McGee, Kobato Kai, Lamb, Little Sisters Disciples, National Down Syndrome Congress, National Down Syndrome Society, Organizations, Roman Catholic, Royal Society
related to Prognosis · 20
Down syndrome → Between, Data, Down, Following, From, In, In Sweden, Individuals, It, Many, Much, Of, Society, Some, Sweden, The, The National Down Syndrome, This, Those, United States
related to Name · 15
Down syndrome → Down, Down's, Father, He, Health, His, However, In, John Langdon Down, NHS, NIH, The, United Kingdom, United States National Institutes, While
related to Other hominids · 13
Down syndrome → Bornean, Down, Fossilized, In, It, Japan, Kanako, Kumamoto Sanctuary, Kyoto University, Neanderthal, Neanderthals, The, Tina
related to Cognitive development · 12
Down syndrome → As, Augmentative, Behavioral, Disabilities Education Act, Down, Education, In, Individuals, School-age, Some, Speech, United States
related to Epidemiology · 12
Down syndrome → About, Although, At, Down, Globally, In, It, Maternal, More, Norway, The, United States
related to Mechanism · 11
Down syndrome → Alzheimer's, Amyloid, Down, ETS2, It, MicroRNAs, Other, Senile, Some, The, This
related to Abortion rates · 10
Down syndrome → About, As, Denmark, Down, Europe, Iceland, In, Rates, United States, When

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Important terminology

syndrome age may people 21 chromosome screening children common often trisomy risk first also 50 individuals problems cases years life

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Down syndromeCausesThird copy of chromosome 211.00infobox
Down syndromeDiagnostic methodPrenatal screening, genetic testing1.00infobox
Down syndromeDurationLifelong1.00infobox
Down syndromeFrequency5.4 million (0.1%)1.00infobox
Down syndromeNamed afterJohn Langdon Down1.00infobox
Down syndromeOther namesDown's syndrome, Down's, trisomy 211.00infobox
Down syndromePrognosisLife expectancy 50 to 60 years (developed world)1.00infobox
Down syndromeRisk factorsOlder age of mother, prior affected child1.00infobox
Down syndromeSpecialtyMedical genetics, pediatrics1.00infobox
Down syndromeSymptomsDelayed development, characteristic physical features, mild to moderate intellectual disability1.00infobox
Down syndromeTreatmentPhysical therapy, occupational therapy, speech therapy, educational support, supported work environment1.00infobox
Down syndromeUsual onsetMostly at conception, rarely after fertilization1.00infobox
Down syndromeis amost common chromosomal abnormality0.90text
Down syndromeis astrong risk factor for developing keratoconus0.90text

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