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Caretaker gene

Caretaker genes encode products that stabilize the genome. Fundamentally, mutations in caretaker genes lead to genomic instability. Tumor cells arise from two distinct classes of genomic instability: mutational instability arising from changes in the nucleotide sequence of DNA and chromosomal instability arising from improper rearrangement of chromosomes.

Products, Genes in context & Gatekeepers, caretakers, and cellular aging

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Genes in context

29 related topics

Gatekeepers, caretakers, and cellular aging

6 related topics

Mutations in context

2 related topics

Overview

9 related topics

Topics to explore

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Overview

Genes in context

Gatekeepers, caretakers, and cellular aging

Mutations in context

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Map overview Semantic statistics

Caretaker gene

Nodes51
Edges50
Triples20
Avg. degree1.96
Density0.039216
Components1

How this topic connects Entity context

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Caretaker gene

Top relations

related to Pathways to cancer via the caretakers · 7
Caretaker gene → Caretaker, DNA, Factors, Rounds, Specific DNA, The, Thus
related to Gatekeepers, caretakers, and cellular aging · 6
Caretaker gene → Because, Caretakers, Increased, It, The, This
related to Mutations in context · 5
Caretaker gene → Although, Caretaker, However, It, This

Important terminology Word statistics

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Important terminology

genes mutations caretaker cell cancer gatekeeper cells growth cellular gene lead dna products aging genome tumor proliferation encode repair example

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Xeroderma pigmentosuminstance ofdefects in nucleotide excision repair pathways are associated with premature aging phenotypes in diseases0.80text
Trichothiodystrophyinstance ofdefects in nucleotide excision repair pathways are associated with premature aging phenotypes in diseases0.80text
Caretaker generelated to Gatekeepers, caretakers, and cellular agingBecause0.60section
Caretaker generelated to Gatekeepers, caretakers, and cellular agingIncreased0.60section
Caretaker generelated to Gatekeepers, caretakers, and cellular agingThis0.60section
Caretaker generelated to Gatekeepers, caretakers, and cellular agingThe0.60section
Caretaker generelated to Gatekeepers, caretakers, and cellular agingCaretakers0.60section
Caretaker generelated to Gatekeepers, caretakers, and cellular agingIt0.60section
Caretaker generelated to Mutations in contextIt0.60section
Caretaker generelated to Mutations in contextThis0.60section
Caretaker generelated to Mutations in contextCaretaker0.60section
Caretaker generelated to Mutations in contextHowever0.60section

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