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Caretaker genes encode products that stabilize the genome. Fundamentally, mutations in caretaker genes lead to genomic instability. Tumor cells arise from two distinct classes of genomic instability: mutational instability arising from changes in the nucleotide sequence of DNA and chromosomal instability arising from improper rearrangement of chromosomes.
Products, Genes in context & Gatekeepers, caretakers, and cellular aging
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genes mutations caretaker cell cancer gatekeeper cells growth cellular gene lead dna products aging genome tumor proliferation encode repair example
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Xeroderma pigmentosum | instance of | defects in nucleotide excision repair pathways are associated with premature aging phenotypes in diseases | 0.80 | text |
| Trichothiodystrophy | instance of | defects in nucleotide excision repair pathways are associated with premature aging phenotypes in diseases | 0.80 | text |
| Caretaker gene | related to Gatekeepers, caretakers, and cellular aging | Because | 0.60 | section |
| Caretaker gene | related to Gatekeepers, caretakers, and cellular aging | Increased | 0.60 | section |
| Caretaker gene | related to Gatekeepers, caretakers, and cellular aging | This | 0.60 | section |
| Caretaker gene | related to Gatekeepers, caretakers, and cellular aging | The | 0.60 | section |
| Caretaker gene | related to Gatekeepers, caretakers, and cellular aging | Caretakers | 0.60 | section |
| Caretaker gene | related to Gatekeepers, caretakers, and cellular aging | It | 0.60 | section |
| Caretaker gene | related to Mutations in context | It | 0.60 | section |
| Caretaker gene | related to Mutations in context | This | 0.60 | section |
| Caretaker gene | related to Mutations in context | Caretaker | 0.60 | section |
| Caretaker gene | related to Mutations in context | However | 0.60 | section |
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