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Genotoxicity

Genotoxicity is the property of chemical agents that damage the genetic information within a cell causing mutations, which may lead to cancer. While genotoxicity is often confused with mutagenicity, all mutagens are genotoxic, but some genotoxic substances are not mutagenic. The alteration can have direct or indirect effects on the DNA: the induction of…

Cancer, In vitro toxicology testing & Mechanism

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Overview

Mechanism

Test techniques

In vitro toxicology testing

Cancer

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Map overview Semantic statistics

Genotoxicity

Nodes85
Edges84
Triples33
Avg. degree1.98
Density0.023529
Components1

How this topic connects Entity context

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Genotoxicity

Top relations

related to Cancer · 11
Genotoxicity → Differences, DNA, Genotoxic, In, Individuals, Regions, ROS, Similarly, Some, The, This
related to Comet assay · 7
Genotoxicity → Cells, Comet, DNA, However, The, The DNA, This
related to in vivo testing · 6
Genotoxicity → ADME, Causes, DNA, It, PCEs, The
related to Test techniques · 3
Genotoxicity → The, They, With
is a · 1
Genotoxicity → property of chemical agents that damage the genetic information within a cell causing mutations

Important terminology Word statistics

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Important terminology

dna cancer damage genotoxic cells genetic cause may mutations assay aberrations mutation chromosomal many vitro vivo base effects breaks repair

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Genotoxicityis aproperty of chemical agents that damage the genetic information within a cell causing mutations0.90text
deletionsinstance ofCancerGenotoxic effects0.80text
breaks and/or rearrangements can lead to cancer if the damage does not immediately lead to cell deathinstance ofCancerGenotoxic effects0.80text
DNA crosslinksinstance ofStudies of humans with genetic deficiencies in DNA repair pathways have revealed that their kidneys are particularly vulnerable to DNA damages0.80text
DNA breaksinstance ofStudies of humans with genetic deficiencies in DNA repair pathways have revealed that their kidneys are particularly vulnerable to DNA damages0.80text
transcription-blocking damageinstance ofStudies of humans with genetic deficiencies in DNA repair pathways have revealed that their kidneys are particularly vulnerable to DNA damages0.80text
Genotoxicityrelated to CancerGenotoxic0.60section
Genotoxicityrelated to CancerRegions0.60section
Genotoxicityrelated to CancerSome0.60section
Genotoxicityrelated to CancerIn0.60section
Genotoxicityrelated to CancerDNA0.60section
Genotoxicityrelated to CancerIndividuals0.60section

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    Min side: 3
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