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Single-strand selective monofunctional uracil DNA glycosylase is an enzyme that in humans is encoded by the SMUG1 gene. SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair.
Function, Interactions & Role in cancer
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dna uracil cancer repair glycosylase ung gene also damage uracil-dna bp function low survival 5-fu thus base chr response shown
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SMUG1 | Aliases | SMUG1, FDG, HMUDG, UNG3, single-strand-selective monofunctional uracil-DNA glycosylase 1 | 1.00 | infobox |
| SMUG1 | Band | 15|15 F3 | 1.00 | infobox |
| SMUG1 | Bgee | secondary oocyte | 1.00 | infobox |
| SMUG1 | Bgee | primary oocyte | 1.00 | infobox |
| SMUG1 | Bgee | neural layer of retina | 1.00 | infobox |
| SMUG1 | Bgee | tail of embryo | 1.00 | infobox |
| SMUG1 | Bgee | zygote | 1.00 | infobox |
| SMUG1 | Bgee | otic vesicle | 1.00 | infobox |
| SMUG1 | Bgee | hair follicle | 1.00 | infobox |
| SMUG1 | Bgee | retinal pigment epithelium | 1.00 | infobox |
| SMUG1 | Bgee | epithelium of urethra | 1.00 | infobox |
| SMUG1 | Bgee | otolith organ | 1.00 | infobox |
| SMUG1 | BioGPS | More reference expression data | 1.00 | infobox |
| SMUG1 | Chr. | Chromosome 15 (mouse) | 1.00 | infobox |
| SMUG1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SMUG1 | End | 103,075,519 bp | 1.00 | infobox |
| SMUG1 | Ensembl | ENSG00000123415 | 1.00 | infobox |
| SMUG1 | Entrez | 23583 | 1.00 | infobox |
| SMUG1 | External IDs | OMIM: 607753; MGI: 1918976; GeneCards: SMUG1 | 1.00 | infobox |
| SMUG1 | Gene location (Mouse) | Gene location (Mouse)Chr.Chromosome 15 (mouse)Band15|15 F3Start103,061,717 bpEnd103,075,519 bp | 1.00 | infobox |
| SMUG1 | Gene ontology | DNA binding | 1.00 | infobox |
| SMUG1 | Gene ontology | uracil DNA N-glycosylase activity | 1.00 | infobox |
| SMUG1 | Gene ontology | DNA N-glycosylase activity | 1.00 | infobox |
| SMUG1 | Gene ontology | protein binding | 1.00 | infobox |
| SMUG1 | Gene ontology | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | 1.00 | infobox |
| SMUG1 | Gene ontology | hydrolase activity | 1.00 | infobox |
| SMUG1 | Gene ontology | single-strand selective uracil DNA N-glycosylase activity | 1.00 | infobox |
| SMUG1 | Gene ontology | nucleolus | 1.00 | infobox |
| SMUG1 | Gene ontology | nucleus | 1.00 | infobox |
| SMUG1 | Gene ontology | nucleoplasm | 1.00 | infobox |
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