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SMUG1: Function, Interactions & Role in cancer

Single-strand selective monofunctional uracil DNA glycosylase is an enzyme that in humans is encoded by the SMUG1 gene. SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair.

Language: English [EN]
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SMUG1 topic overview

The analysis highlights Function, Interactions and Role in cancer as prominent areas in the source structure around SMUG1.

Related topics
12
Source areas
4
Connected nodes
16
Extracted relationships
84
Concept neighborhoods
10
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 4 topics
Overview · 4 topics
Interactions · 3 topics
Role in cancer · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SMUG1, FDG, HMUDG, UNG3, single-strand-selective monofunctional uracil-DNA glycosylase 1
Band
15|15 F3
Bgee
secondary oocyte · primary oocyte · neural layer of retina · tail of embryo · zygote
BioGPS
More reference expression data
Chr.
Chromosome 15 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Role in cancer

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SMUG1 connects Entity context

The extracted context around SMUG1 shows recurring relationship patterns in the source. For example, SMUG1 → base-excision repair, cellular response to DNA damage stimulus, depyrimidination, DNA binding, DNA N-glycosylase activity, DNA repair, hydrolase activity, nucleolus, nucleoplasm, nucleus, oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity, protein binding, single-strand selective uracil DNA N-glycosylase activity, uracil DNA N-glycosylase activity Another extracted example is SMUG1 → ATM, BRCA1, DNA, FU, In, Loss, Low SMUG1, One, Preclinical, Thus SMUG1, XRCC1. Use these groups to spot repeated connection types before inspecting the individual relationships.

SMUG1

Top relations

Gene ontology · 14
SMUG1 → base-excision repair, cellular response to DNA damage stimulus, depyrimidination, DNA binding, DNA N-glycosylase activity, DNA repair, hydrolase activity, nucleolus, nucleoplasm, nucleus, oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity, protein binding, single-strand selective uracil DNA N-glycosylase activity, uracil DNA N-glycosylase activity
related to Role in cancer · 11
SMUG1 → ATM, BRCA1, DNA, FU, In, Loss, Low SMUG1, One, Preclinical, Thus SMUG1, XRCC1
related to Role in drug response · 11
SMUG1 → Also, And, Current, DNA, Fluorouracil, FU, In, Investigation, It, TTP, UNG
Bgee · 10
SMUG1 → epithelium of urethra, hair follicle, neural layer of retina, otic vesicle, otolith organ, primary oocyte, retinal pigment epithelium, secondary oocyte, tail of embryo, zygote
RNA expression pattern · 10
SMUG1 → epithelium of urethra, hair follicle, neural layer of retina, otic vesicle, otolith organ, primary oocyte, retinal pigment epithelium, secondary oocyte, tail of embryo, zygote
related to Function · 9
SMUG1 → Current, DNA, In, MBD4, Other DNA, TDG, UNG, Uracil, Uracil-DNA
related to Interactions · 2
SMUG1 → DKC1, RBPMS
Aliases · 1
SMUG1 → SMUG1, FDG, HMUDG, UNG3, single-strand-selective monofunctional uracil-DNA glycosylase 1
Band · 1
SMUG1 → 15|15 F3
BioGPS · 1
SMUG1 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna uracil cancer repair glycosylase ung gene also damage uracil-dna bp function low survival 5-fu thus base chr response shown

SMUG1 relationships Subject–Predicate–Object triples

TTTA extracted 84 structured relationships around SMUG1. Examples in this analysis include SMUG1 → Aliases → SMUG1, FDG, HMUDG, UNG3, single-strand-selective monofunctional uracil-DNA glycosylase 1 and SMUG1 → Band → 15|15 F3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SMUG1AliasesSMUG1, FDG, HMUDG, UNG3, single-strand-selective monofunctional uracil-DNA glycosylase 11.00infobox
SMUG1Band15|15 F31.00infobox
SMUG1Bgeesecondary oocyte1.00infobox
SMUG1Bgeeprimary oocyte1.00infobox
SMUG1Bgeeneural layer of retina1.00infobox
SMUG1Bgeetail of embryo1.00infobox
SMUG1Bgeezygote1.00infobox
SMUG1Bgeeotic vesicle1.00infobox
SMUG1Bgeehair follicle1.00infobox
SMUG1Bgeeretinal pigment epithelium1.00infobox
SMUG1Bgeeepithelium of urethra1.00infobox
SMUG1Bgeeotolith organ1.00infobox
SMUG1BioGPSMore reference expression data1.00infobox
SMUG1Chr.Chromosome 15 (mouse)1.00infobox
SMUG1DatabasesNCBI: entry; OMA: entry1.00infobox
SMUG1End103,075,519 bp1.00infobox
SMUG1EnsemblENSG000001234151.00infobox
SMUG1Entrez235831.00infobox
SMUG1External IDsOMIM: 607753; MGI: 1918976; GeneCards: SMUG11.00infobox
SMUG1Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 15 (mouse)Band15|15 F3Start103,061,717 bpEnd103,075,519 bp1.00infobox
SMUG1Gene ontologyDNA binding1.00infobox
SMUG1Gene ontologyuracil DNA N-glycosylase activity1.00infobox
SMUG1Gene ontologyDNA N-glycosylase activity1.00infobox
SMUG1Gene ontologyprotein binding1.00infobox
SMUG1Gene ontologyoxidized pyrimidine nucleobase lesion DNA N-glycosylase activity1.00infobox
SMUG1Gene ontologyhydrolase activity1.00infobox
SMUG1Gene ontologysingle-strand selective uracil DNA N-glycosylase activity1.00infobox
SMUG1Gene ontologynucleolus1.00infobox
SMUG1Gene ontologynucleus1.00infobox
SMUG1Gene ontologynucleoplasm1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SMUG1 bring nearby vocabulary together. In this analysis, examples include Cancer, Uracil and Low. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SMUG1
    • Cancer
    • Uracil
    • Low
    • Survival
    • Repair
    • Base
    • Function
    • Shown
    • Thus
    • Damage
    • Ung
    • Expression
  • smug1
    • Cancer
    • Uracil
    • Low
    • Survival
    • Repair
    • Base
    • Function
    • Shown
    • Thus
    • Damage
    • Ung
    • Expression
  • base excision repair
    • Oxidative
    • Damage
    • Thus
    • Glycosylase
    • Repair
    • Uracil-dna
    • Cancer
    • Enzyme
    • Removes
    • Single-
    • Smug1
    • Carcinogenesis
  • role in cancer
    • Carcinogenesis
    • Gastric
    • Low
    • Survival
    • Smug1
    • Oxidative
    • Shown
    • Thus
    • Damage
    • Location
    • Monofunctional
    • Mouse
  • gene
    • Location
    • Monofunctional
    • Mouse
    • Selective
    • Single-strand
    • Bp
    • Chr
    • Response
    • Function
    • Uracil-dna
    • Uracil
    • Also
  • function
    • Location
    • Mouse
    • Bp
    • Chr
    • Response
    • Gene
    • Uracil-dna
    • Band
    • Monofunctional
    • Process
    • Removes
    • Selective
  • enzyme
    • Glycosylase
    • Monofunctional
    • Selective
    • Single-strand
    • Oxidative
    • Base
    • Gene
    • Damage
    • Uracil
    • Smug1
  • uracil
    • Removal
    • Ung
    • Uracil-dna
    • 5-fu

Connections between topic areas Semantic bridges

For SMUG1, one of the stronger structural bridges in this analysis connects SMUG1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SMUG1 — Overview · splits 12 ⟂ 5
SMUG1 — Function · splits 12 ⟂ 5
SMUG1 — Interactions · splits 13 ⟂ 4

Map overview Semantic statistics

SMUG1

Nodes17
Edges16
Triples84
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around SMUG1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Role in cancer, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SMUG1 · EN edition · Analysis: TopicsToTalkAbout

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