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VAMP2: Function, Clinical significance & Interactions

Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene.

Language: English [EN]
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VAMP2 topic overview

The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around VAMP2.

Related topics
23
Source areas
4
Connected nodes
27
Extracted relationships
139
Concept neighborhoods
11
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 9 topics
Clinical significance · 6 topics
Interactions · 6 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
VAMP2, SYB2, VAMP-2, vesicle associated membrane protein 2, NEDHAHM
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3FIE, 3FII, 3RK2, 3RK3, 3RL0
Band
17p13.1 · 11|11 B3
Bgee
Brodmann area 10 · frontal pole · paraflocculus of cerebellum · right frontal lobe · right hemisphere of cerebellum
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How VAMP2 connects Entity context

The extracted context around VAMP2 shows recurring relationship patterns in the source. For example, VAMP2 → calcium-dependent protein binding, calcium-ion regulated exocytosis, calmodulin binding, cell junction, cellular response to insulin stimulus, clathrin-coated vesicle, clathrin-coated vesicle membrane, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane, clathrin-sculpted glutamate transport vesicle membrane, clathrin-sculpted monoamine transport vesicle membrane, cytoplasmic vesicle, cytosol, eosinophil degranulation, exocytosis, glutamate secretion, Golgi to plasma membrane protein transport, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, long-term potentiation Another extracted example is VAMP2 → amygdala, anterior cingulate cortex, anterior pituitary, Brodmann area 10, CA3 field, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, frontal pole, neural layer of retina, nucleus accumbens, paraflocculus of cerebellum, perirhinal cortex, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, subiculum, superior frontal gyrus. Use these groups to spot repeated connection types before inspecting the individual relationships.

VAMP2

Top relations

Gene ontology · 63
VAMP2 → calcium-dependent protein binding, calcium-ion regulated exocytosis, calmodulin binding, cell junction, cellular response to insulin stimulus, clathrin-coated vesicle, clathrin-coated vesicle membrane, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane, clathrin-sculpted glutamate transport vesicle membrane, clathrin-sculpted monoamine transport vesicle membrane, cytoplasmic vesicle, cytosol, eosinophil degranulation, exocytosis, glutamate secretion, Golgi to plasma membrane protein transport, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, long-term potentiation
Bgee · 20
VAMP2 → amygdala, anterior cingulate cortex, anterior pituitary, Brodmann area 10, CA3 field, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, frontal pole, neural layer of retina, nucleus accumbens, paraflocculus of cerebellum, perirhinal cortex, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, subiculum, superior frontal gyrus
RNA expression pattern · 20
VAMP2 → amygdala, anterior cingulate cortex, anterior pituitary, Brodmann area 10, CA3 field, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, frontal pole, neural layer of retina, nucleus accumbens, paraflocculus of cerebellum, perirhinal cortex, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, subiculum, superior frontal gyrus
related to Function · 6
VAMP2 → It, Mice, SNAP25, Synaptobrevins/VAMPs, The, VAMP
related to Interactions · 4
VAMP2 → RABAC1, SNAP-25, SNAP23, STX1A
Band · 2
VAMP2 → 11|11 B3, 17p13.1
Chr. · 2
VAMP2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
VAMP2 → 68,983,210 bp, 8,163,546 bp
Aliases · 1
VAMP2 → VAMP2, SYB2, VAMP-2, vesicle associated membrane protein 2, NEDHAHM
Available structures · 1
VAMP2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3FIE, 3FII, 3RK2, 3RK3, 3RL0

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp protein gene membrane chr human band chromosome 17 complex location fusion vesicle mouse synaptic function vesicle-associated search 163 546

VAMP2 relationships Subject–Predicate–Object triples

TTTA extracted 139 structured relationships around VAMP2. Examples in this analysis include VAMP2 → Aliases → VAMP2, SYB2, VAMP-2, vesicle associated membrane protein 2, NEDHAHM and VAMP2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3FIE, 3FII, 3RK2, 3RK3, 3RL0. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
VAMP2AliasesVAMP2, SYB2, VAMP-2, vesicle associated membrane protein 2, NEDHAHM1.00infobox
VAMP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3FIE, 3FII, 3RK2, 3RK3, 3RL01.00infobox
VAMP2Band17p13.11.00infobox
VAMP2Band11|11 B31.00infobox
VAMP2BgeeBrodmann area 101.00infobox
VAMP2Bgeefrontal pole1.00infobox
VAMP2Bgeeparaflocculus of cerebellum1.00infobox
VAMP2Bgeeright frontal lobe1.00infobox
VAMP2Bgeeright hemisphere of cerebellum1.00infobox
VAMP2Bgeecingulate gyrus1.00infobox
VAMP2Bgeeanterior cingulate cortex1.00infobox
VAMP2Bgeeamygdala1.00infobox
VAMP2Bgeenucleus accumbens1.00infobox
VAMP2Bgeeanterior pituitary1.00infobox
VAMP2Bgeeperirhinal cortex1.00infobox
VAMP2Bgeeentorhinal cortex1.00infobox
VAMP2Bgeesuperior frontal gyrus1.00infobox
VAMP2Bgeeprimary visual cortex1.00infobox
VAMP2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
VAMP2Bgeeneural layer of retina1.00infobox
VAMP2BgeeCA3 field1.00infobox
VAMP2Bgeecerebellar cortex1.00infobox
VAMP2Bgeeprefrontal cortex1.00infobox
VAMP2Bgeesubiculum1.00infobox
VAMP2BioGPSMore reference expression data1.00infobox
VAMP2Chr.Chromosome 17 (human)1.00infobox
VAMP2Chr.Chromosome 11 (mouse)1.00infobox
VAMP2DatabasesNCBI: entry; OMA: entry1.00infobox
VAMP2End8,163,546 bp1.00infobox
VAMP2End68,983,210 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around VAMP2 bring nearby vocabulary together. In this analysis, examples include Gene, Docking and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • VAMP2
    • Gene
    • Docking
    • Function
    • Fusion
    • Neurotransmitter
    • Search
    • Synaptic
    • Synaptobrevin
    • Vesicle
    • Vesicle-associated
    • Location
    • Chromosome
  • vamp2
    • Gene
    • Docking
    • Function
    • Fusion
    • Neurotransmitter
    • Search
    • Synaptic
    • Synaptobrevin
    • Vesicle
    • Vesicle-associated
    • Location
    • Chromosome
  • protein
    • Vamp2
    • Gene
    • Function
    • Search
    • Synaptobrevin
    • Synaptosomal-associated
    • Syntaxin
    • Vesicle
    • Vesicle-associated
    • Complex
    • Location
    • Chromosome
  • gene
    • Location
    • Chromosome
    • Human
    • Membrane
    • Vamp2
    • Bp
    • Chr
    • Protein
    • End
    • Function
    • Mouse
    • Search
  • vesicle-associated membrane protein
    • Protein
    • Encoded
    • Function
    • Gene
    • Humans
    • Membrane
    • Search
    • Synaptobrevin
    • Vamp2
    • Vesicle
    • Vesicle-associated
    • Location
  • function
    • Search
    • Vesicle
    • Location
    • Chromosome
    • Human
    • Interactions
    • Membrane
    • Reading
    • References
    • Significance
    • Bp
    • Chr
  • clinical significance
    • Interactions
    • Reading
    • References
    • Significance
    • Function
    • Search
    • Vesicle
    • Location
    • Chromosome
    • Human
    • Membrane
    • Bp
  • fusion
    • Docking
    • Neurotransmitter
    • Mouse
    • Search
    • Synaptic
    • Synaptobrevin
    • Synaptosomal-associated
    • Syntaxin
    • Vesicle
    • Location
    • Vamp2
    • Human

Connections between topic areas Semantic bridges

For VAMP2, one of the stronger structural bridges in this analysis connects VAMP2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
VAMP2Function · splits 18 ⟂ 10
VAMP2Clinical significance · splits 21 ⟂ 7
VAMP2Interactions · splits 21 ⟂ 7
VAMP2Overview · splits 25 ⟂ 3

Map overview Semantic statistics

VAMP2

Nodes28
Edges27
Triples139
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around VAMP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — VAMP2 · EN edition · Analysis: TopicsToTalkAbout

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