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5-HT2A receptor

The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and functions as a G protein-coupled receptor (GPCR). It is a cell surface receptor that activates multiple intracellular signalling cascades. Like all 5-HT2 receptors, the 5-HT2A receptor is coupled to the Gq/G11 signaling pathway. It is the primary…

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Aliases
HTR2A, 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A
Band
13q14.2
Bgee
buccal mucosa cell · middle temporal gyrus · frontal pole · Brodmann area 23 · Brodmann area 10
BioGPS
More reference expression data
Chr.
Chromosome 13 (human)
Databases
NCBI: entry; OMA: entry

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Overview

History

Gene

Tissue distribution

Structure

Function

Ligands

Methods to analyse the receptor

Clinical significance

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Map overview Semantic statistics

5-HT2A receptor

Nodes368
Edges367
Triples301
Avg. degree1.99
Density0.005435
Components1

How this topic connects Entity context

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5-HT2A receptor

Top relations

Gene ontology · 67
5-HT2A receptor → 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, activation of phospholipase C activity, ageing, animal behavior, artery smooth muscle contraction, axon, behavioral response to cocaine, caveola, cell body fiber, cell death, cell projection, cellular calcium ion homeostasis, chemical synaptic transmission, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, dendritic shaft, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain
related to history · 17
5-HT2A receptor → Gaddum, HT, HT1, HT1C, HT2, HT2A, HT2B, HT2C, HT2F, HT3, In, John Gaddum, Later, LSD, Picarelli, The, Thus
related to Structure · 17
5-HT2A receptor → BOL-148, Bryan Roth, D155, DMT, EBP, EM, GPCR, H8, HT2A, Its, Ligands, LSD, OBP, RS130-180, Structural, The, These
related to Tissue distribution · 17
5-HT2A receptor → A1, Additionally, AMPA, BAT, Cimbi-36, CNS, Especially, GABAA, Golgi, HT1A, HT2A, HT2A/2C, In, It, OX2, Purkinje, Whole-body
related to Positive allosteric modulators · 16
5-HT2A receptor → AB0124, Another, CTW0404, CTW0419, DOI, DOI-induced, HT2A, HT2B, HT2C, Instead, JPC0323, Positive, The, These, They, Unlike
has effect · 15
5-HT2A receptor → ACTH, Activation, Alzheimer's, CNS, DMT, DOI, HT2A, LSD, Other, Physiological, Primarily, Probable, Role, Smooth, TNF-alpha-induced
related to Gene · 14
5-HT2A receptor → A-1438G, C102T, His452Tyr, HT2A, HTR2, HTR2A, HTR2B, HTR2C, In, Many, Probable, Several, T102C, The
related to Agonists · 12
5-HT2A receptor → Activation, Agonists, Both, However, HPPD, HT2A, LSD, On, PFC, Psychedelics, Serotonin, Some
related to Function · 12
5-HT2A receptor → Activation, Additionally, Dysregulation, Functionally, GPCR, GPCRs, HT2A, IP3, It, Notably, PLC, The
related to Serotonin-elevating drugs · 12
5-HT2A receptor → Besides, Examples, HT2A, HTP, In, MAOIs, MDMA, Serotonin, Serotonin-elevating, SNRIs, SRAs, SSRIs

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Important terminology

receptor 5-ht2a serotonin receptors effects agonists htr2a gene agonist anti-inflammatory selective also 5-ht2c potent psychedelics 5-ht2 psychedelic studies lsd human

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
5-HT2A receptorAliasesHTR2A, 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A1.00infobox
5-HT2A receptorBand13q14.21.00infobox
5-HT2A receptorBgeebuccal mucosa cell1.00infobox
5-HT2A receptorBgeemiddle temporal gyrus1.00infobox
5-HT2A receptorBgeefrontal pole1.00infobox
5-HT2A receptorBgeeBrodmann area 231.00infobox
5-HT2A receptorBgeeBrodmann area 101.00infobox
5-HT2A receptorBgeeBrodmann area 461.00infobox
5-HT2A receptorBgeeendothelial cell1.00infobox
5-HT2A receptorBgeeorbitofrontal cortex1.00infobox
5-HT2A receptorBgeesuperior frontal gyrus1.00infobox
5-HT2A receptorBgeeprimary visual cortex1.00infobox
5-HT2A receptorBioGPSMore reference expression data1.00infobox
5-HT2A receptorChr.Chromosome 13 (human)1.00infobox
5-HT2A receptorDatabasesNCBI: entry; OMA: entry1.00infobox
5-HT2A receptorEnd46,897,076 bp1.00infobox
5-HT2A receptorEnsemblENSG000001024681.00infobox
5-HT2A receptorEntrez33561.00infobox
5-HT2A receptorExternal IDsOMIM: 182135; MGI: 109521; GeneCards: HTR2A1.00infobox
5-HT2A receptorGene location (Human)Gene location (Human)Chr.Chromosome 13 (human)Band13q14.2Start46,831,546 bpEnd46,897,076 bp1.00infobox
5-HT2A receptorGene ontology1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding1.00infobox
5-HT2A receptorGene ontologyG protein-coupled receptor activity1.00infobox
5-HT2A receptorGene ontologyvirus receptor activity1.00infobox
5-HT2A receptorGene ontologysignal transducer activity1.00infobox
5-HT2A receptorGene ontologyG-protein alpha-subunit binding1.00infobox
5-HT2A receptorGene ontologyG protein-coupled serotonin receptor activity1.00infobox
5-HT2A receptorGene ontologyserotonin binding1.00infobox
5-HT2A receptorGene ontologyneurotransmitter receptor activity1.00infobox
5-HT2A receptorGene ontologyprotein binding1.00infobox
5-HT2A receptorGene ontologyprotein-containing complex binding1.00infobox

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