Telomeric repeat-binding factor 2

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Structure and domains

C-terminus Motif Dimerization N-terminus Homodimers

25 related topics

Disease relevance of TERF2

Telomerase Cancer Extracellular signal-regulated kinase ERK1 RAS/RAF/MEK/ERK

20 related topics

Function

Metaphase Chromosome Upstream Cell death DNA damage response

19 related topics

Interactions

Amino acid Tyrosine Phenylalanine Interact Ku70

11 related topics

Key facts & relationships

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Aliases: TERF2, TRBF2, TRF2, telomeric repeat binding factor 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H6P, 1VF9, 1VFC, 1W0U, 1XG1, 3BU8, 3BUA, 3K6G, 3SJM, 4M7C, 4RQI
Band: 16q22.1 · 8 D3|8 53.59 cM
Bgee: Brodmann area 46 · sural nerve · ventricular zone · ganglionic eminence · postcentral gyrus
BioGPS: More reference expression data
Chr.: Chromosome 16 (human) · Chromosome 8 (mouse)

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Overview

Structure and domains

C-terminus
Motif Sequence motif
Dimerization Dimerization (chemistry)
N-terminus
Homodimers
Co-immunoprecipitation assay analysis Co-immunoprecipitation
Basic Base (chemistry)
Acidic Acid
Conserved Conserved sequence
Domain Domain (protein)
InterPro
Quaternary structure Protein quaternary structure
Nuclease
DNA synthesis
ATM kinase activation ATM kinase
SLX4
DNA repair
Scaffold Scaffold protein
Myb domain MYB (gene)
Double-stranded
Viral protein
Avian myeloblastosis virus Avian myeloblastosis
XRCC3
TIN2 TINF2
RAP1

Function

Metaphase
Chromosome
Upstream Upstream and downstream (DNA)
Cell death
DNA damage response DNA damage
Oligomeric Oligomeric protein
Cross-link
Amplification Signal transduction pathway
Mutations Mutation
Apoptosis
Phosphorylated Phosphorylation
Conditional deletion Gene knockout
Non-homologous end-joining Non-homologous end joining
Homology directed repair
P53
Cre Cre recombinase
Phenotype
DAPI stain DAPI
Fluorescence in situ hybridization

Interactions

Disease relevance of TERF2

Telomerase
Cancer
Extracellular signal-regulated kinase
ERK1
RAS/RAF/MEK/ERK MAPK/ERK pathway
Melanoma cells Melanoma
Tumor reversion
Tumor cells
Oncogenesis
Natural killer cells Natural killer cell
Dominant negative form Dominant negative mutation
Over-expression
Tumourigenicity Tumorigenicity
Upregulation
Chromosomal instability Chromosome instability
Leukemia
Gastric mucosa tissues Gastric mucosa
TERT
BRCA1
Gastric cancer

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes90

Edges89

Triples116

Avg. degree1.98

Density0.022222

Components1

How this topic connects Entity context

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Telomeric repeat-binding factor 2

Top relations

Gene ontology · 48

Telomeric repeat-binding factor 2 → anterograde axonal transport of messenger ribonucleoprotein complex, axon cytoplasm, cell cycle, cellular senescence, chromosome, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded telomeric DNA binding, enzyme binding, G-rich strand telomeric DNA binding, Mre11 complex, negative regulation of beta-galactosidase activity, negative regulation of cellular senescence, negative regulation of exonuclease activity, negative regulation of gene expression, negative regulation of t-circle formation, negative regulation of telomere capping, negative regulation of telomere maintenance, negative regulation of telomere maintenance via recombination, negative regulation of telomere maintenance via semi-conservative replication

Bgee · 20

Telomeric repeat-binding factor 2 → Brodmann area 46, ciliary body, epithelium of colon, external carotid artery, ganglionic eminence, gastrocnemius muscle, genital tubercle, internal carotid artery, orbitofrontal cortex, postcentral gyrus, prefrontal cortex, retinal pigment epithelium, Rostral migratory stream, secondary oocyte, sural nerve, tail of embryo, testicle, thymus, ventricular zone, zygote

RNA expression pattern · 20

related to External links · 4

Telomeric repeat-binding factor 2 → Human Telomeric, PDB, PDBe-KB, TERF2

Band · 2

Telomeric repeat-binding factor 2 → 16q22.1, 8 D3|8 53.59 cM

Chr. · 2

Telomeric repeat-binding factor 2 → Chromosome 16 (human), Chromosome 8 (mouse)

End · 2

Telomeric repeat-binding factor 2 → 107,096,547 bp, 69,408,571 bp

Aliases · 1

Telomeric repeat-binding factor 2 → TERF2, TRBF2, TRF2, telomeric repeat binding factor 2

Available structures · 1

Telomeric repeat-binding factor 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H6P, 1VF9, 1VFC, 1W0U, 1XG1, 3BU8, 3BUA, 3K6G, 3SJM, 4M7C, 4RQI

BioGPS · 1

Telomeric repeat-binding factor 2 → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

terf2 domain dna protein telomeric shelterin proteins chromosome telomeres also atm binding human kinase factor bp telomere terf1 complex trfh

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Telomeric repeat-binding factor 2	Aliases	TERF2, TRBF2, TRF2, telomeric repeat binding factor 2	1.00	infobox
Telomeric repeat-binding factor 2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H6P, 1VF9, 1VFC, 1W0U, 1XG1, 3BU8, 3BUA, 3K6G, 3SJM, 4M7C, 4RQI	1.00	infobox
Telomeric repeat-binding factor 2	Band	16q22.1	1.00	infobox
Telomeric repeat-binding factor 2	Band	8 D3\|8 53.59 cM	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	Brodmann area 46	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	sural nerve	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	ventricular zone	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	ganglionic eminence	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	postcentral gyrus	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	epithelium of colon	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	orbitofrontal cortex	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	testicle	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	prefrontal cortex	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	gastrocnemius muscle	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	tail of embryo	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	genital tubercle	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	internal carotid artery	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	external carotid artery	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	zygote	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	Rostral migratory stream	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	retinal pigment epithelium	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	ciliary body	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	secondary oocyte	1.00	infobox
Telomeric repeat-binding factor 2	Bgee	thymus	1.00	infobox
Telomeric repeat-binding factor 2	BioGPS	More reference expression data	1.00	infobox
Telomeric repeat-binding factor 2	Chr.	Chromosome 16 (human)	1.00	infobox
Telomeric repeat-binding factor 2	Chr.	Chromosome 8 (mouse)	1.00	infobox
Telomeric repeat-binding factor 2	Databases	NCBI: entry; OMA: entry	1.00	infobox
Telomeric repeat-binding factor 2	End	69,408,571 bp	1.00	infobox
Telomeric repeat-binding factor 2	End	107,096,547 bp	1.00	infobox

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