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Rap1

Rap1 (Ras-proximate-1 or Ras-related protein 1) is a small GTPase, which are small cytosolic proteins that act like cellular switches and are vital for effective signal transduction. There are two isoforms of the Rap1 protein, each encoded by a separate gene, RAP1A and RAP1B. Rap1 belongs to Ras-related protein family.

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Key facts & relationships

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Domains
InterPro
HGNC
9855
Locus
Chr. 1 p13.3
NCBI gene
5906
OMIM
179520
RefSeq
NM_002884

Topics to explore

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Overview

Effectors

Ligands

Advanced semantic analysis

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Map overview Semantic statistics

Rap1

Nodes34
Edges33
Triples74
Avg. degree1.94
Density0.058824
Components1

How this topic connects Entity context

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Rap1

Top relations

related to RAPL · 17
Rap1 → Because RAPL, GFFKR, In T-cells, LFA-1, Mutation, Overexpression, Rap1-binding, Rap1-dependent, Rap1G12V, RAPL, RAPL-deficient, SKAP1, T-cell, TCR, The, This, While
related to Mst1 · 13
Rap1 → Although Rap1, ICAM-1, It, LFA-1, Mst1, Mst1-independent, RAPL, RNAi-mediated, Ste20, TCR, TCR-mediated, The, This
related to PKD · 13
Rap1 → C3G, For, Mst1, PKD, PKD-dependent, Rap1 GEFs, Rap1-associated, Rap1-dependent, RAPL, TCR, The PKD, This, Thus
related to RIAM · 13
Rap1 → An, Ena/VASP, Given, GTP-interacting, In, Like RAPL, Mst1-independent, PH, RA, Rap1-dependent, Ras, RIAM, The
related to Ligands · 3
Rap1 → CalDAG-GEFI, Rap1 Metformin, RASA3
Domains · 1
Rap1 → InterPro
HGNC · 1
Rap1 → 9855
Locus · 1
Rap1 → Chr. 1 p13.3
NCBI gene · 1
Rap1 → 5906
OMIM · 1
Rap1 → 179520

Important terminology Word statistics

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Important terminology

rapl protein proteins lfa-1 mst1 pkd riam active adhesion ras integrins role small gtpases tcr integrin activation may regulate rap1a

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Rap1DomainsInterPro1.00infobox
Rap1HGNC98551.00infobox
Rap1LocusChr. 1 p13.31.00infobox
Rap1NCBI gene59061.00infobox
Rap1OMIM1795201.00infobox
Rap1RefSeqNM_0028841.00infobox
Rap1Search forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
Rap1StructuresSwiss-model1.00infobox
Rap1SymbolRAP1A1.00infobox
Rap1UniProtP628341.00infobox
Rap1is amember0.90text
RAPLinstance ofRap1 interaction may thus be central to the subsequent activation of Rap1 and triggering of downstream effectors0.80text

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