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TINF2: Interactions & Overview

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene. TINF2 is a component of the shelterin protein complex found at the end of telomeres.

Language: English [EN]
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TINF2 topic overview

The analysis highlights Interactions and Overview as prominent areas in the source structure around TINF2.

Related topics
8
Source areas
2
Connected nodes
10
Extracted relationships
88
Concept neighborhoods
8
Bridge connections
10

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 4 topics
Overview · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TINF2, DKCA3, TIN2, TERF1 interacting nuclear factor 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3BQO, 3BU8
Band
14q12 · 14 C3|14 28.19 cM
Bgee
granulocyte · right adrenal gland · right adrenal cortex · left adrenal gland · monocyte
BioGPS
n/a
Chr.
Chromosome 14 (human) · Chromosome 14 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TINF2 connects Entity context

The extracted context around TINF2 shows recurring relationship patterns in the source. For example, TINF2 → blood, bone marrow cell, epiblast, granulocyte, left adrenal cortex, left adrenal gland, monocyte, primary oocyte, primitive streak, right adrenal cortex, right adrenal gland, secondary oocyte, seminiferous tubule, somite, spermatocyte, spleen, tail of embryo, tonsil, zygote Another extracted example is TINF2 → chromosome, DNA binding, negative regulation of epithelial cell proliferation, negative regulation of protein ADP-ribosylation, negative regulation of telomere maintenance via telomerase, nuclear body, nuclear matrix, nuclear telomere cap complex, nucleoplasm, nucleus, perinucleolar chromocenter, protein binding, protein localization to chromosome, telomeric region, regulation of telomere maintenance via telomere lengthening, shelterin complex, telomere, telomere assembly, telomere capping, telomeric DNA binding. Use these groups to spot repeated connection types before inspecting the individual relationships.

TINF2

Top relations

Bgee · 19
TINF2 → blood, bone marrow cell, epiblast, granulocyte, left adrenal cortex, left adrenal gland, monocyte, primary oocyte, primitive streak, right adrenal cortex, right adrenal gland, secondary oocyte, seminiferous tubule, somite, spermatocyte, spleen, tail of embryo, tonsil, zygote
Gene ontology · 19
TINF2 → chromosome, DNA binding, negative regulation of epithelial cell proliferation, negative regulation of protein ADP-ribosylation, negative regulation of telomere maintenance via telomerase, nuclear body, nuclear matrix, nuclear telomere cap complex, nucleoplasm, nucleus, perinucleolar chromocenter, protein binding, protein localization to chromosome, telomeric region, regulation of telomere maintenance via telomere lengthening, shelterin complex, telomere, telomere assembly, telomere capping, telomeric DNA binding
RNA expression pattern · 19
TINF2 → blood, bone marrow cell, epiblast, granulocyte, left adrenal cortex, left adrenal gland, monocyte, primary oocyte, primitive streak, right adrenal cortex, right adrenal gland, secondary oocyte, seminiferous tubule, somite, spermatocyte, spleen, tail of embryo, tonsil, zygote
related to External links · 4
TINF2 → Dyskeratosis CongenitaPDBe-KB, GeneReviews/NCBI/NIH/UW, Human TERF1-interacting, PDB
related to Interactions · 3
TINF2 → ACD, POT1, TERF1
Band · 2
TINF2 → 14 C3|14 28.19 cM, 14q12
Chr. · 2
TINF2 → Chromosome 14 (human), Chromosome 14 (mouse)
End · 2
TINF2 → 24,242,674 bp, 55,919,277 bp
Aliases · 1
TINF2 → TINF2, DKCA3, TIN2, TERF1 interacting nuclear factor 2
Available structures · 1
TINF2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3BQO, 3BU8

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp human chr chromosome band gene protein nuclear 14 end factor location shelterin mouse component complex external terf1-interacting search 242

TINF2 relationships Subject–Predicate–Object triples

TTTA extracted 88 structured relationships around TINF2. Examples in this analysis include TINF2 → Aliases → TINF2, DKCA3, TIN2, TERF1 interacting nuclear factor 2 and TINF2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3BQO, 3BU8. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TINF2AliasesTINF2, DKCA3, TIN2, TERF1 interacting nuclear factor 21.00infobox
TINF2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3BQO, 3BU81.00infobox
TINF2Band14q121.00infobox
TINF2Band14 C3|14 28.19 cM1.00infobox
TINF2Bgeegranulocyte1.00infobox
TINF2Bgeeright adrenal gland1.00infobox
TINF2Bgeeright adrenal cortex1.00infobox
TINF2Bgeeleft adrenal gland1.00infobox
TINF2Bgeemonocyte1.00infobox
TINF2Bgeeleft adrenal cortex1.00infobox
TINF2Bgeebone marrow cell1.00infobox
TINF2Bgeeblood1.00infobox
TINF2Bgeetonsil1.00infobox
TINF2Bgeespleen1.00infobox
TINF2Bgeeprimary oocyte1.00infobox
TINF2Bgeesecondary oocyte1.00infobox
TINF2Bgeeprimitive streak1.00infobox
TINF2Bgeezygote1.00infobox
TINF2Bgeeepiblast1.00infobox
TINF2Bgeeseminiferous tubule1.00infobox
TINF2Bgeespermatocyte1.00infobox
TINF2Bgeetail of embryo1.00infobox
TINF2Bgeesomite1.00infobox
TINF2BioGPSn/a1.00infobox
TINF2Chr.Chromosome 14 (human)1.00infobox
TINF2Chr.Chromosome 14 (mouse)1.00infobox
TINF2DatabasesNCBI: entry; OMA: entry1.00infobox
TINF2End24,242,674 bp1.00infobox
TINF2End55,919,277 bp1.00infobox
TINF2EnsemblENSG00000092330 ENSG000002849151.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TINF2 bring nearby vocabulary together. In this analysis, examples include Nuclear, Factor and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TINF2
    • Nuclear
    • Factor
    • Protein
    • Gene
    • Human
    • Available
    • Complex
    • Component
    • Entry
    • Ncbi
    • Pdb
    • Search
  • tinf2
    • Nuclear
    • Factor
    • Protein
    • Gene
    • Human
    • Available
    • Complex
    • Component
    • Entry
    • Ncbi
    • Pdb
    • Search
  • gene
    • Location
    • Chromosome
    • Nuclear
    • Bp
    • C3
    • Chr
    • Human
    • Mouse
    • Search
    • Terf1
    • Tinf2
    • End
  • protein
    • Complex
    • Component
    • Shelterin
    • Tinf2
    • End
    • Gene
    • Encoded
    • Found
    • Humans
    • Telomeres
    • C3
    • Entry
  • shelterin
    • Complex
    • End
    • Found
    • Telomeres
    • Tinf2
    • C3
    • Entry
    • Mouse
    • Ncbi
    • Search
    • Terf1
    • Location
  • interactions
    • External
    • Reading
    • References
    • Available
    • Pdb
    • Search
    • Terf1
    • Location
    • Chromosome
    • Nuclear
    • Bp
    • Chr
  • terf1
    • Search
    • Tinf2
    • C3
    • Entry
    • Mouse
    • Ncbi
    • Band
  • telomeres
    • Tinf2

Connections between topic areas Semantic bridges

For TINF2, one of the stronger structural bridges in this analysis connects TINF2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TINF2Overview · splits 6 ⟂ 5
TINF2Interactions · splits 6 ⟂ 5

Map overview Semantic statistics

TINF2

Nodes11
Edges10
Triples88
Avg. degree1.82
Density0.181818
Components1

Source & methodology

TTTA analyzes the structure around TINF2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TINF2 · EN edition · Analysis: TopicsToTalkAbout

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