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Micronization

Micronization is the process of reducing the average diameter of the particles of a solid material, typically into the micrometre range and in some cases the nanometre range. It is a form of comminution and is a critical unit operation in the manufacture of active pharmaceutical ingredients, food ingredients, pigments, agrochemicals and other fine…

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Overview

Mechanical comminution

Supercritical fluid methods

Limitations of mechanical micronization

Particle size characterization

Applications

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Micronization

Nodes89
Edges88
Triples80
Avg. degree1.98
Density0.022472
Components1

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Micronization

Top relations

related to Dry co-micronization · 14
Micronization → Drug Administration, Dry, Each, February, Food, GRAS, Iroko Pharmaceuticals, NSAID, October, SoluMatrix Fine Particle Technology, The, Tivorbex, Vivlodex, Zorvolex
related to Particle size characterization · 12
Micronization → Because, Different, European Pharmacopoeia, Fraunhofer, ISO, Japanese Pharmacopoeia, Laser, Light Diffraction Measurement, Mie, Particle Size, The, United States Pharmacopeia
related to Mechanical comminution · 8
Micronization → CFR Part, Conventional, ICH Q7, Industrial, Mechanical, The, These, True
related to Inhalation drug products · 7
Micronization → API, DPIs, Drug, Emerging, In, MDIs, The
related to Limitations of mechanical micronization · 6
Micronization → Although, Because, Mechanical, Raman, The, X-ray
related to Other · 6
Micronization → Because, Drug Administration, Food, Micronized, Progesterone, Prometrium
is a · 3
Micronization → most widely used industrial technique, nanomilling approach in which the drug substance is milled in a dry state together with GRAS excipients in a single unit operation, process of reducing the average diameter of the particles of a solid material
related to Mechanics of Micronization · 1
Micronization → The

Important terminology Word statistics

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Important terminology

particle size milling particles dry mechanical dissolution jet pharmaceutical drug diameter supercritical fluid solid typically range surface energy used material

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Micronizationis aprocess of reducing the average diameter of the particles of a solid material0.90text
Micronizationis ananomilling approach in which the drug substance is milled in a dry state together with GRAS excipients in a single unit operation0.90text
Micronizationis amost widely used industrial technique0.90text
ICH Q7instance ofdominate commercial pharmaceutical production and operate under current good manufacturing practice regulations0.80text
21 CFR Part 211instance ofregulations0.80text
ICH Q7.The choice of micronization technology depends on the active pharmaceutical ingredient's physical propertiesinstance ofregulations0.80text
nozzle geometryinstance ofand can be used to obtain either crystalline or amorphous micronized forms.Particle size and morphology are controlled both by macroscopic parameters0.80text
flow rateinstance ofand can be used to obtain either crystalline or amorphous micronized forms.Particle size and morphology are controlled both by macroscopic parameters0.80text
and by molecular-level effects of pressureinstance ofand can be used to obtain either crystalline or amorphous micronized forms.Particle size and morphology are controlled both by macroscopic parameters0.80text
temperatureinstance ofand can be used to obtain either crystalline or amorphous micronized forms.Particle size and morphology are controlled both by macroscopic parameters0.80text
solute concentrationinstance ofand can be used to obtain either crystalline or amorphous micronized forms.Particle size and morphology are controlled both by macroscopic parameters0.80text
antisolvent-to-solvent ratioinstance ofand can be used to obtain either crystalline or amorphous micronized forms.Particle size and morphology are controlled both by macroscopic parameters0.80text

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