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Nonsteroidal antiandrogen

A nonsteroidal antiandrogen (NSAA) is an antiandrogen with a nonsteroidal chemical structure. They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT). NSAAs are used in the treatment of androgen-dependent conditions in…

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ATC code
L02BB
Biological target
Androgen receptor
Chemical class
Nonsteroidal
Synonyms
Nonsteroidal androgen receptor antagonists
Use
Prostate cancer; Acne; Hirsutism; Seborrhea; Pattern hair loss; Hyperandrogenism; Transgender hormone therapy; Male precocious puberty; Priapism

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Nonsteroidal antiandrogen

Nodes89
Edges88
Triples89
Avg. degree1.98
Density0.022472
Components1

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Nonsteroidal antiandrogen

Top relations

related to Further reading · 72
Nonsteroidal antiandrogen → Advancements, Androgen, Antes, Barrington, Battmann, Biol, BJU Int, Bonfils, Bouchoux, Breast, Cerede, Chem, ChemMedChem, Clin Prostate Cancer, Cochrane, Combined, Craig Jordan, Curr, Dahm, Dalton JT
related to External links · 4
Nonsteroidal antiandrogen → Media, Nonsteroidal, Wikimedia Commons, Wiktionary-logo-en-v2
ATC code · 1
Nonsteroidal antiandrogen → L02BB
Biological target · 1
Nonsteroidal antiandrogen → Androgen receptor
Chemical class · 1
Nonsteroidal antiandrogen → Nonsteroidal
Synonyms · 1
Nonsteroidal antiandrogen → Nonsteroidal androgen receptor antagonists
Use · 1
Nonsteroidal antiandrogen → Prostate cancer; Acne; Hirsutism; Seborrhea; Pattern hair loss; Hyperandrogenism; Transgender hormone therapy; Male precocious puberty; Priapism

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Important terminology

treatment prostate cancer nonsteroidal androgen doi antiandrogens receptor pmid 10 also due marketed nsaas acne ar development used nsaa hirsutism

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Nonsteroidal antiandrogenATC codeL02BB1.00infobox
Nonsteroidal antiandrogenBiological targetAndrogen receptor1.00infobox
Nonsteroidal antiandrogenChemical classNonsteroidal1.00infobox
Nonsteroidal antiandrogenSynonymsNonsteroidal androgen receptor antagonists1.00infobox
Nonsteroidal antiandrogenUseProstate cancer; Acne; Hirsutism; Seborrhea; Pattern hair loss; Hyperandrogenism; Transgender hormone therapy; Male precocious puberty; Priapism1.00infobox
progestogenicinstance ofshow no off-target hormonal activity0.80text
glucocorticoidinstance ofshow no off-target hormonal activity0.80text
or antimineralocorticoid activityinstance ofshow no off-target hormonal activity0.80text
and lack antigonadotropic effectsinstance ofshow no off-target hormonal activity0.80text
nauseainstance ofVery little-used due to a high incidence of interstitial pneumonitis and high rates of several unique and unfavorable side effects0.80text
vomitinginstance ofVery little-used due to a high incidence of interstitial pneumonitis and high rates of several unique and unfavorable side effects0.80text
visual disturbancesinstance ofVery little-used due to a high incidence of interstitial pneumonitis and high rates of several unique and unfavorable side effects0.80text

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