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Progesterone (medication): History, Community, Culture & Applications

Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms, and low sex hormone levels in women, as well as gender affirming therapy in transgender women. It is also used in…

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Progesterone (medication) topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Progesterone (medication).

Related topics
377
Source areas
11
Connected nodes
388
Extracted relationships
55
Concept neighborhoods
53
Bridge connections
388

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Medical uses · 70 topics
Overview · 55 topics
Side effects · 55 topics
History · 46 topics
Pharmacology · 46 topics
Chemistry · 35 topics
Contraindications · 27 topics
Interactions · 15 topics
Research · 12 topics
Society and culture · 12 topics
Overdose · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
G03DA04 (WHO)
Bioavailability
Oral: <2.4% Vaginal (micronized insert): 4–8%
CAS Number
57-83-0 Y
ChEBI
CHEBI:17026 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Progesterone (medication) connects Entity context

The extracted context around Progesterone (medication) shows recurring relationship patterns in the source. For example, Progesterone (medication) → AU: S4 (Prescription only), CA: ℞-only, In general: ℞ (Prescription only) Another extracted example is Progesterone (medication) → Interactive image. Use these groups to spot repeated connection types before inspecting the individual relationships.

Progesterone (medication)

Top relations

Legal status · 3
Progesterone (medication) → AU: S4 (Prescription only), CA: ℞-only, In general: ℞ (Prescription only)
3D model (JSmol) · 1
Progesterone (medication) → Interactive image
AHFS/Drugs.com · 1
Progesterone (medication) → Monograph
ATC code · 1
Progesterone (medication) → G03DA04 (WHO)
Bioavailability · 1
Progesterone (medication) → Oral: 2.4% Vaginal (micronized insert): 4–8%
CAS Number · 1
Progesterone (medication) → 57-83-0 Y
ChEBI · 1
Progesterone (medication) → CHEBI:17026 Y
ChEMBL · 1
Progesterone (medication) → ChEMBL103 Y
ChemSpider · 1
Progesterone (medication) → 5773 Y
Drug class · 1
Progesterone (medication) → Progestogen; Antimineralocorticoid; Neurosteroid

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

progesterone oral vaginal brand women effects breast also marketed name use intramuscular estrogen injection available used may estradiol found first

Progesterone (medication) relationships Subject–Predicate–Object triples

TTTA extracted 55 structured relationships around Progesterone (medication). Examples in this analysis include Progesterone (medication) → 3D model (JSmol) → Interactive image and Progesterone (medication) → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Progesterone (medication)3D model (JSmol)Interactive image1.00infobox
Progesterone (medication)AHFS/Drugs.comMonograph1.00infobox
Progesterone (medication)ATC codeG03DA04 (WHO)1.00infobox
Progesterone (medication)BioavailabilityOral: <2.4% Vaginal (micronized insert): 4–8%1.00infobox
Progesterone (medication)CAS Number57-83-0 Y1.00infobox
Progesterone (medication)ChEBICHEBI:17026 Y1.00infobox
Progesterone (medication)ChEMBLChEMBL103 Y1.00infobox
Progesterone (medication)ChemSpider5773 Y1.00infobox
Progesterone (medication)Drug classProgestogen; Antimineralocorticoid; Neurosteroid1.00infobox
Progesterone (medication)DrugBankDB00396 Y1.00infobox
Progesterone (medication)Elimination half-life• Oral: 5 hours (with food) * Sublingual: 6–7 hours • Vaginal: 14–50 hours • Topical: 30–40 hours • IM: 20–28 hours • SC: 13–18 hours • IVTooltip Intravenous injection: 3–90 min…1.00infobox
Progesterone (medication)ExcretionBile and urine1.00infobox
Progesterone (medication)FormulaC21H30O21.00infobox
Progesterone (medication)IUPHAR/BPS23771.00infobox
Progesterone (medication)KEGGD00066 Y1.00infobox
Progesterone (medication)Legal statusAU: S4 (Prescription only)1.00infobox
Progesterone (medication)Legal statusCA: ℞-only1.00infobox
Progesterone (medication)Legal statusIn general: ℞ (Prescription only)1.00infobox
Progesterone (medication)MedlinePlusa6040171.00infobox
Progesterone (medication)Melting point126 °C (259 °F)1.00infobox
Progesterone (medication)MetabolismMainly liver: • 5α- and 5β-reductase • 3α-Tooltip 3α-Hydroxysteroid dehydrogenase and 3β-HSDTooltip 3β-Hydroxysteroid dehydrogenase • 20α-Tooltip 20α-Hydroxysteroid dehydrogenas…1.00infobox
Progesterone (medication)Metabolites• Dihydroprogesterones • Pregnanolones • Pregnanediols • 20α-Hydroxyprogesterone • 17α-Hydroxyprogesterone • Pregnanetriols • 11-Deoxycorticosterone (and glucuronide/sulfate con…1.00infobox
Progesterone (medication)Molar mass314.469 g·mol−11.00infobox
Progesterone (medication)Other namesP4; Pregnenedione; Pregn-4-ene-3,20-dione1.00infobox
Progesterone (medication)Protein binding98–99%: • Albumin: 80% • CBGTooltip Corticosteroid-binding globulin: 18% • SHBGTooltip Sex hormone-binding globulin: <1% • Free: 1–2%1.00infobox
Progesterone (medication)PubChem CID59941.00infobox
Progesterone (medication)Routes of administrationBy mouth, sublingual, topical, vaginal, rectal, intramuscular, subcutaneous, intrauterine1.00infobox
Progesterone (medication)Specific rotation[α]D25 = +172 to +182° (2% in dioxane, β-form)1.00infobox
Progesterone (medication)Trade namesPrometrium, Utrogestan, Endometrin, others1.00infobox
Progesterone (medication)UNII4G7DS2Q64Y1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Progesterone (medication) bring nearby vocabulary together. In this analysis, examples include Oral, Vaginal and Marketed. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Progesterone (medication)
    • Oral
    • Vaginal
    • Marketed
    • Women
    • Effects
    • Use
    • Breast
    • Found
    • Available
    • Intramuscular
    • May
    • Estradiol
  • progesterone (medication)
    • Oral
    • Vaginal
    • Marketed
    • Women
    • Effects
    • Use
    • Breast
    • Found
    • Available
    • Intramuscular
    • May
    • Estradiol
  • steroid hormone
    • Combination
    • Transdermal
    • Women
    • Used
    • Pregnancy
    • Effects
    • Neurosteroid
    • Addition
    • Estrogen
    • Name
    • Breast
    • Oil
  • hormone therapy
    • Combination
    • Transdermal
    • Women
    • Used
    • Pregnancy
    • Effects
    • Neurosteroid
    • Addition
    • Estrogen
    • Name
    • Breast
    • Oil
  • low sex hormone levels
    • Combination
    • Transdermal
    • Women
    • Used
    • Pregnancy
    • Effects
    • Neurosteroid
    • Addition
    • Estrogen
    • Name
    • Breast
    • Oil
  • injection
    • Intramuscular
    • Oil
    • Use
    • Name
    • Available
    • Estradiol
    • Marketed
    • Introduced
    • Vaginal
    • Progesterone
    • Mg
    • Oral
  • progesterone vaginal ring
    • Oral
    • Vaginal
    • Intramuscular
    • Mg
    • Women
    • Marketed
    • Effects
    • Endometrial
    • Use
    • Found
    • Breast
    • Available
  • birth control
    • Women
    • Vaginal
    • Introduced
    • States
    • United
    • Risk
    • Used
    • Available
    • Name
    • Marketed
    • Progesterone
    • Pregnancy

Connections between topic areas Semantic bridges

For Progesterone (medication), one of the stronger structural bridges in this analysis connects Progesterone (medication) with Medical uses. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Progesterone (medication)Medical uses · splits 318 ⟂ 71
Progesterone (medication)Overview · splits 333 ⟂ 56
Progesterone (medication)Side effects · splits 333 ⟂ 56
Progesterone (medication)Pharmacology · splits 342 ⟂ 47
Progesterone (medication)History · splits 342 ⟂ 47
Progesterone (medication)Chemistry · splits 353 ⟂ 36
Progesterone (medication)Contraindications · splits 361 ⟂ 28
Progesterone (medication)Interactions · splits 373 ⟂ 16
Progesterone (medication)Society and culture · splits 376 ⟂ 13
Progesterone (medication)Research · splits 376 ⟂ 13
Progesterone (medication)Overdose · splits 384 ⟂ 5

Map overview Semantic statistics

Progesterone (medication)

Nodes389
Edges388
Triples55
Avg. degree1.99
Density0.005141
Components1

Source & methodology

TTTA analyzes the structure around Progesterone (medication) to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Progesterone (medication) · EN edition · Analysis: TopicsToTalkAbout

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