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E2F4: Structure, Function & Interactions

Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.

Language: English [EN]
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E2F4 topic overview

The analysis highlights Structure, Function and Interactions as prominent areas in the source structure around E2F4.

Related topics
12
Source areas
4
Connected nodes
16
Extracted relationships
109
Concept neighborhoods
11
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 5 topics
Function · 3 topics
Interactions · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
E2F4, E2F-4, E2F transcription factor 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CF7
Band
16q22.1 · 8|8 D3
Bgee
pancreatic ductal cell · granulocyte · left uterine tube · anterior pituitary · transverse colon
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How E2F4 connects Entity context

The extracted context around E2F4 shows recurring relationship patterns in the source. For example, E2F4 → animal organ morphogenesis, blood circulation, cell cycle, cell projection organization, cell volume homeostasis, centriole assembly, cilium assembly, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, epithelial cell development, mitotic cell cycle, motile cilium assembly, multi-ciliated epithelial cell differentiation, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleus Another extracted example is E2F4 → anterior pituitary, apex of heart, body of stomach, embryo, genital tubercle, granulocyte, left uterine tube, lip, mucosa of transverse colon, muscle of thigh, neural layer of retina, pancreatic ductal cell, right lobe of thyroid gland, tail of embryo, transverse colon, upper lobe of left lung, ventricular zone, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

E2F4

Top relations

Gene ontology · 37
E2F4 → animal organ morphogenesis, blood circulation, cell cycle, cell projection organization, cell volume homeostasis, centriole assembly, cilium assembly, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, epithelial cell development, mitotic cell cycle, motile cilium assembly, multi-ciliated epithelial cell differentiation, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleus
Bgee · 19
E2F4 → anterior pituitary, apex of heart, body of stomach, embryo, genital tubercle, granulocyte, left uterine tube, lip, mucosa of transverse colon, muscle of thigh, neural layer of retina, pancreatic ductal cell, right lobe of thyroid gland, tail of embryo, transverse colon, upper lobe of left lung, ventricular zone, yolk sac, zygote
RNA expression pattern · 19
E2F4 → anterior pituitary, apex of heart, body of stomach, embryo, genital tubercle, granulocyte, left uterine tube, lip, mucosa of transverse colon, muscle of thigh, neural layer of retina, pancreatic ductal cell, right lobe of thyroid gland, tail of embryo, transverse colon, upper lobe of left lung, ventricular zone, yolk sac, zygote
related to External links · 9
E2F4 → E2F4 This, FactorBookE2F4PDBe-KB, Human Transcription, Medicine, Medicine Medical Subject Headings, MeSH, National Library, PDB, United States National Library
Band · 2
E2F4 → 16q22.1, 8|8 D3
Chr. · 2
E2F4 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
E2F4 → 106,032,002 bp, 67,198,918 bp
Aliases · 1
E2F4 → E2F4, E2F-4, E2F transcription factor 4
Available structures · 1
E2F4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CF7
BioGPS · 1
E2F4 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp gene transcription protein chr band factor e2f chromosome 16 location proteins mouse dna domain function external family tumor

E2F4 relationships Subject–Predicate–Object triples

TTTA extracted 109 structured relationships around E2F4. Examples in this analysis include E2F4 → Aliases → E2F4, E2F-4, E2F transcription factor 4 and E2F4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CF7. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
E2F4AliasesE2F4, E2F-4, E2F transcription factor 41.00infobox
E2F4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CF71.00infobox
E2F4Band16q22.11.00infobox
E2F4Band8|8 D31.00infobox
E2F4Bgeepancreatic ductal cell1.00infobox
E2F4Bgeegranulocyte1.00infobox
E2F4Bgeeleft uterine tube1.00infobox
E2F4Bgeeanterior pituitary1.00infobox
E2F4Bgeetransverse colon1.00infobox
E2F4Bgeemucosa of transverse colon1.00infobox
E2F4Bgeeapex of heart1.00infobox
E2F4Bgeebody of stomach1.00infobox
E2F4Bgeeright lobe of thyroid gland1.00infobox
E2F4Bgeeupper lobe of left lung1.00infobox
E2F4Bgeetail of embryo1.00infobox
E2F4Bgeezygote1.00infobox
E2F4Bgeeyolk sac1.00infobox
E2F4Bgeegenital tubercle1.00infobox
E2F4Bgeeventricular zone1.00infobox
E2F4Bgeeembryo1.00infobox
E2F4Bgeeneural layer of retina1.00infobox
E2F4Bgeelip1.00infobox
E2F4Bgeemuscle of thigh1.00infobox
E2F4BioGPSMore reference expression data1.00infobox
E2F4Chr.Chromosome 16 (human)1.00infobox
E2F4Chr.Chromosome 8 (mouse)1.00infobox
E2F4DatabasesNCBI: entry; OMA: entry1.00infobox
E2F4End67,198,918 bp1.00infobox
E2F4End106,032,002 bp1.00infobox
E2F4EnsemblENSG000002052501.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around E2F4 bring nearby vocabulary together. In this analysis, examples include Factor, Transcription and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • E2F4
    • Factor
    • Transcription
    • Human
    • E2f
    • Gene
    • Protein
    • Available
    • Encoded
    • Function
    • Pdb
    • Search
    • Structure
  • e2f4
    • Factor
    • Transcription
    • Human
    • E2f
    • Gene
    • Protein
    • Available
    • Encoded
    • Function
    • Pdb
    • Search
    • Structure
  • protein
    • Transcription
    • Binding
    • Differentiation
    • Dimerization
    • Encoded
    • Dna
    • Domain
    • Suppressor
    • Tumor
    • Proteins
    • E2f
    • Gene
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Transcription
    • End
    • Expression
    • Function
    • Mouse
    • Search
    • Band
  • e2f
    • Family
    • Cell
    • Cycle
    • Function
    • Search
    • E2f4
    • Dna
    • Human
    • Location
    • Chromosome
    • Proteins
    • Bp
  • cell cycle
    • Cycle
    • Dna
    • Family
    • E2f
    • Binding
    • Differentiation
    • Dimerization
    • Encoded
    • End
    • Expression
    • Function
    • Mouse
  • dna binding domain
    • Differentiation
    • Dimerization
    • Cycle
    • Dna
    • Domain
    • Factor
    • Transcription
    • Family
    • Suppressor
    • Tumor
    • Protein
    • Proteins
  • function
    • Search
    • Location
    • Chromosome
    • External
    • Bp
    • Chr
    • E2f
    • Gene
    • Transcription
    • Also
    • Available
    • Binding

Connections between topic areas Semantic bridges

For E2F4, one of the stronger structural bridges in this analysis connects E2F4 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
E2F4Structure · splits 11 ⟂ 6
E2F4Function · splits 13 ⟂ 4
E2F4Overview · splits 14 ⟂ 3
E2F4Interactions · splits 14 ⟂ 3

Map overview Semantic statistics

E2F4

Nodes17
Edges16
Triples109
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around E2F4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — E2F4 · EN edition · Analysis: TopicsToTalkAbout

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