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MED12: Measurement, Interactions & Clinical significance

Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome.

Language: English [EN]
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MED12 topic overview

The analysis highlights Measurement, Interactions and Clinical significance as prominent areas in the source structure around MED12.

Related topics
19
Source areas
3
Connected nodes
22
Extracted relationships
117
Concept neighborhoods
10
Bridge connections
22

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 10 topics
Clinical significance · 7 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MED12, ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230, mediator complex subunit 12, Kto, HDKR
Band
Xq13.1 · X|X D
Bgee
right adrenal cortex · left ovary · right ovary · left adrenal gland · left adrenal cortex
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MED12 connects Entity context

The extracted context around MED12 shows recurring relationship patterns in the source. For example, MED12 → androgen receptor signaling pathway, axis elongation involved in somitogenesis, beta-catenin binding, canonical Wnt signaling pathway, chromatin binding, development of the heart, embryonic brain development, embryonic neurocranium morphogenesis, embryonic organ development, endoderm development, intracellular steroid hormone receptor signaling pathway, mediator complex, membrane, negative regulation of Wnt signaling pathway, neural tube closure, neural tube development, nuclear receptor coactivator activity, nucleoplasm, nucleus, oligodendrocyte development Another extracted example is MED12 → adrenal gland, body of uterus, bone marrow, canal of the cervix, cerebellar cortex, genital tubercle, granulocyte, islet of Langerhans, left adrenal cortex, left adrenal gland, left ovary, neural layer of retina, right adrenal cortex, right lobe of thyroid gland, right ovary, right uterine tube, spleen, tail of embryo, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.

MED12

Top relations

Gene ontology · 45
MED12 → androgen receptor signaling pathway, axis elongation involved in somitogenesis, beta-catenin binding, canonical Wnt signaling pathway, chromatin binding, development of the heart, embryonic brain development, embryonic neurocranium morphogenesis, embryonic organ development, endoderm development, intracellular steroid hormone receptor signaling pathway, mediator complex, membrane, negative regulation of Wnt signaling pathway, neural tube closure, neural tube development, nuclear receptor coactivator activity, nucleoplasm, nucleus, oligodendrocyte development
Bgee · 19
MED12 → adrenal gland, body of uterus, bone marrow, canal of the cervix, cerebellar cortex, genital tubercle, granulocyte, islet of Langerhans, left adrenal cortex, left adrenal gland, left ovary, neural layer of retina, right adrenal cortex, right lobe of thyroid gland, right ovary, right uterine tube, spleen, tail of embryo, thymus
RNA expression pattern · 19
MED12 → adrenal gland, body of uterus, bone marrow, canal of the cervix, cerebellar cortex, genital tubercle, granulocyte, islet of Langerhans, left adrenal cortex, left adrenal gland, left ovary, neural layer of retina, right adrenal cortex, right lobe of thyroid gland, right ovary, right uterine tube, spleen, tail of embryo, thymus
related to Interactions · 7
MED12 → Calcitriol, Cyclin-dependent, G9a, Gli3, MED26, PPARGC1A, SOX9
related to Clinical significance · 5
MED12 → FG, Intellectual, Lujan-Fryns, Mutations, X-linked
Band · 2
MED12 → Xq13.1, X|X D
Chr. · 2
MED12 → X chromosome (human), X chromosome (mouse)
End · 2
MED12 → 100,341,071 bp, 71,144,103 bp
related to External links · 2
MED12 → GeneReviews/NCBI/NIH/UW, MED12-Related Disorders
Aliases · 1
MED12 → MED12, ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230, mediator complex subunit 12, Kto, HDKR

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp chromosome chr band gene mediator 12 location mouse rna polymerase ii transcription subunit external complex 144 103 end

MED12 relationships Subject–Predicate–Object triples

TTTA extracted 117 structured relationships around MED12. Examples in this analysis include MED12 → Aliases → MED12, ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230, mediator complex subunit 12, Kto, HDKR and MED12 → Band → Xq13.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MED12AliasesMED12, ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230, mediator complex subunit 12, Kto, HDKR1.00infobox
MED12BandXq13.11.00infobox
MED12BandX|X D1.00infobox
MED12Bgeeright adrenal cortex1.00infobox
MED12Bgeeleft ovary1.00infobox
MED12Bgeeright ovary1.00infobox
MED12Bgeeleft adrenal gland1.00infobox
MED12Bgeeleft adrenal cortex1.00infobox
MED12Bgeebody of uterus1.00infobox
MED12Bgeeright uterine tube1.00infobox
MED12Bgeespleen1.00infobox
MED12Bgeecanal of the cervix1.00infobox
MED12Bgeeright lobe of thyroid gland1.00infobox
MED12Bgeebone marrow1.00infobox
MED12Bgeetail of embryo1.00infobox
MED12Bgeeislet of Langerhans1.00infobox
MED12Bgeegenital tubercle1.00infobox
MED12Bgeeneural layer of retina1.00infobox
MED12Bgeethymus1.00infobox
MED12Bgeeadrenal gland1.00infobox
MED12Bgeecerebellar cortex1.00infobox
MED12Bgeegranulocyte1.00infobox
MED12BioGPSMore reference expression data1.00infobox
MED12Chr.X chromosome (human)1.00infobox
MED12Chr.X chromosome (mouse)1.00infobox
MED12DatabasesNCBI: entry; OMA: entry1.00infobox
MED12End71,144,103 bp1.00infobox
MED12End100,341,071 bp1.00infobox
MED12EnsemblENSG000001846341.00infobox
MED12Entrez99681.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MED12 bring nearby vocabulary together. In this analysis, examples include Mediator, Gene and Chromosome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MED12
    • Mediator
    • Gene
    • Chromosome
    • Human
    • Complex
    • Hormone
    • Mutations
    • Polymerase
    • Receptor
    • Rna
    • Subunit
    • Thyroid
  • med12
    • Mediator
    • Gene
    • Chromosome
    • Human
    • Complex
    • Hormone
    • Mutations
    • Polymerase
    • Receptor
    • Rna
    • Subunit
    • Thyroid
  • gene
    • Chromosome
    • Human
    • Location
    • Mediator
    • Bp
    • Chr
    • Complex
    • End
    • Ii
    • Med12
    • Mouse
    • Polymerase
  • x chromosome
    • Human
    • Gene
    • Bp
    • Chr
    • Location
    • Mediator
    • Band
    • Med12
    • Complex
    • End
    • Ii
    • Mouse
  • thyroid hormone receptor alpha
    • Receptor
    • Thyroid
    • Med12
    • Entry
    • Ii
    • Mouse
    • Mutations
    • Ncbi
    • Polymerase
    • Rna
    • Transcription
    • Uterine
  • clinical significance
    • External
    • Interactions
    • Significance
    • Complex
    • Subunit
    • Location
    • Mediator
    • Gene
    • Bp
    • Chr
    • Human
    • Med12
  • interactions
    • External
    • Significance
    • Complex
    • Subunit
    • Location
    • Mediator
    • Med12
  • calcitriol receptor
    • Thyroid
    • Mutations
    • Ncbi
    • Rna
    • Transcription
    • Uterine

Connections between topic areas Semantic bridges

For MED12, one of the stronger structural bridges in this analysis connects MED12 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MED12Interactions · splits 12 ⟂ 11
MED12Clinical significance · splits 15 ⟂ 8
MED12Overview · splits 20 ⟂ 3

Map overview Semantic statistics

MED12

Nodes23
Edges22
Triples117
Avg. degree1.91
Density0.086957
Components1

Source & methodology

TTTA analyzes the structure around MED12 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MED12 · EN edition · Analysis: TopicsToTalkAbout

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