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NRF1: Function, Interactions & Overview

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The…

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NRF1 topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around NRF1.

Related topics
25
Source areas
3
Connected nodes
28
Extracted relationships
88
Concept neighborhoods
13
Bridge connections
28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 12 topics
Overview · 9 topics
Interactions · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NRF1, ALPHA-PAL, nuclear respiratory factor 1
Band
7q32.2 · 6 A3.3|6 12.47 cM
Bgee
cerebellar hemisphere · right hemisphere of cerebellum · right uterine tube · ventricular zone · apex of heart
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 6 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NRF1 connects Entity context

The extracted context around NRF1 shows recurring relationship patterns in the source. For example, NRF1 → core promoter sequence-specific DNA binding, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, extracellular exosome, generation of precursor metabolites and energy, mitochondrion organization, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, protein homodimerization activity, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, transcription by RNA polymerase II, transcription, DNA-templated Another extracted example is NRF1 → anterior pituitary, apex of heart, cerebellar hemisphere, embryo, epiblast, ganglionic eminence, gastrocnemius muscle, granulocyte, Paneth cell, primary oocyte, right hemisphere of cerebellum, right uterine tube, Rostral migratory stream, secondary oocyte, sural nerve, thymus, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

NRF1

Top relations

Gene ontology · 19
NRF1 → core promoter sequence-specific DNA binding, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, extracellular exosome, generation of precursor metabolites and energy, mitochondrion organization, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, protein homodimerization activity, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, transcription by RNA polymerase II, transcription, DNA-templated
Bgee · 18
NRF1 → anterior pituitary, apex of heart, cerebellar hemisphere, embryo, epiblast, ganglionic eminence, gastrocnemius muscle, granulocyte, Paneth cell, primary oocyte, right hemisphere of cerebellum, right uterine tube, Rostral migratory stream, secondary oocyte, sural nerve, thymus, ventricular zone, zygote
RNA expression pattern · 18
NRF1 → anterior pituitary, apex of heart, cerebellar hemisphere, embryo, epiblast, ganglionic eminence, gastrocnemius muscle, granulocyte, Paneth cell, primary oocyte, right hemisphere of cerebellum, right uterine tube, Rostral migratory stream, secondary oocyte, sural nerve, thymus, ventricular zone, zygote
related to External links · 6
NRF1 → FactorBookNrf1 This, Medicine, Medicine Medical Subject Headings, MeSH, National Library, United States National Library
related to Function · 4
NRF1 → COX, DNA, ETC, Nrf2
related to Interactions · 3
NRF1 → DYNLL1, PPARGC1A, PPRC1
Band · 2
NRF1 → 6 A3.3|6 12.47 cM, 7q32.2
Chr. · 2
NRF1 → Chromosome 6 (mouse), Chromosome 7 (human)
End · 2
NRF1 → 129,757,082 bp, 30,153,457 bp
Aliases · 1
NRF1 → NRF1, ALPHA-PAL, nuclear respiratory factor 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein bp nuclear human factor chr band gene mitochondrial variants characterized chromosome expression dna transcription cellular regulation location function genes

NRF1 relationships Subject–Predicate–Object triples

TTTA extracted 88 structured relationships around NRF1. Examples in this analysis include NRF1 → Aliases → NRF1, ALPHA-PAL, nuclear respiratory factor 1 and NRF1 → Band → 7q32.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NRF1AliasesNRF1, ALPHA-PAL, nuclear respiratory factor 11.00infobox
NRF1Band7q32.21.00infobox
NRF1Band6 A3.3|6 12.47 cM1.00infobox
NRF1Bgeecerebellar hemisphere1.00infobox
NRF1Bgeeright hemisphere of cerebellum1.00infobox
NRF1Bgeeright uterine tube1.00infobox
NRF1Bgeeventricular zone1.00infobox
NRF1Bgeeapex of heart1.00infobox
NRF1Bgeeanterior pituitary1.00infobox
NRF1Bgeegranulocyte1.00infobox
NRF1Bgeeganglionic eminence1.00infobox
NRF1Bgeesural nerve1.00infobox
NRF1Bgeegastrocnemius muscle1.00infobox
NRF1Bgeezygote1.00infobox
NRF1Bgeeprimary oocyte1.00infobox
NRF1Bgeesecondary oocyte1.00infobox
NRF1Bgeeepiblast1.00infobox
NRF1BgeeRostral migratory stream1.00infobox
NRF1BgeePaneth cell1.00infobox
NRF1Bgeethymus1.00infobox
NRF1Bgeeembryo1.00infobox
NRF1BioGPSMore reference expression data1.00infobox
NRF1Chr.Chromosome 7 (human)1.00infobox
NRF1Chr.Chromosome 6 (mouse)1.00infobox
NRF1DatabasesNCBI: entry; OMA: entry1.00infobox
NRF1End129,757,082 bp1.00infobox
NRF1End30,153,457 bp1.00infobox
NRF1EnsemblENSG000001064591.00infobox
NRF1Entrez48991.00infobox
NRF1External IDsOMIM: 600879; MGI: 1332235; GeneCards: NRF11.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NRF1 bring nearby vocabulary together. In this analysis, examples include Nuclear, Expression and Genes. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NRF1
    • Nuclear
    • Expression
    • Genes
    • Regulating
    • Mitochondrial
    • Human
    • Activates
    • Cellular
    • Databases
    • Functions
    • Growth
    • Key
  • nrf1
    • Nuclear
    • Expression
    • Genes
    • Regulating
    • Mitochondrial
    • Human
    • Activates
    • Cellular
    • Databases
    • Functions
    • Growth
    • Key
  • transcription factor
    • Activates
    • Cellular
    • Functions
    • Growth
    • Key
    • Metabolic
    • Replication
    • Required
    • Respiration
    • Databases
    • Dna
    • Expression
  • metabolic genes
    • Cellular
    • Growth
    • Regulating
    • Replication
    • Required
    • Respiration
    • Transcription
    • Mitochondrial
    • Dna
    • Genes
    • Key
    • Metabolic
  • mitochondrial dna
    • Nuclear
    • Dna
    • Mitochondrial
    • Regulating
    • Functions
    • Growth
    • Key
    • Metabolic
    • Nrf-1
    • Replication
    • Required
    • Respiration
  • cellular growth
    • Functions
    • Growth
    • Key
    • Metabolic
    • Replication
    • Required
    • Respiration
    • Transcription
    • Dna
    • Expression
    • Factor
    • Genes
  • transcription
    • Activates
    • Cellular
    • Functions
    • Growth
    • Key
    • Metabolic
    • Replication
    • Required
    • Respiration
    • Dna
    • Expression
    • Factor
  • function
    • Nuclear
    • Gene
    • Location
    • Mitochondrial
    • External
    • Human
    • Functions
    • Growth
    • Key
    • Metabolic
    • Mouse
    • Nrf-1

Connections between topic areas Semantic bridges

For NRF1, one of the stronger structural bridges in this analysis connects NRF1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NRF1Function · splits 16 ⟂ 13
NRF1Overview · splits 19 ⟂ 10
NRF1Interactions · splits 24 ⟂ 5

Map overview Semantic statistics

NRF1

Nodes29
Edges28
Triples88
Avg. degree1.93
Density0.068966
Components1

Source & methodology

TTTA analyzes the structure around NRF1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NRF1 · EN edition · Analysis: TopicsToTalkAbout

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