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ACSF3

Acyl-CoA synthetase family member 3 (ACSF3) is a mitochondrial enzyme encoded by the ACSF3 gene. It is required for the degradation of malonic acid and methylmalonic acid and provides the precursor for mitochondrial fatty acid synthesis (mtFAS) and mitochondrial lysine malonylation. The enzyme belongs to the acyl-CoA synthetase family.

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6.2.1.76
↗
Aliases
ACSF3, acyl-CoA synthetase family member 3
Band
16q24.3 · 8|8 E1
Bgee
mucosa of transverse colon · granulocyte · right adrenal gland · sural nerve · bone marrow cell
BioGPS
n/a
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)

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ACSF3

Nodes152
Edges151
Triples158
Avg. degree1.99
Density0.013158
Components1

How this topic connects Entity context

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ACSF3

Top relations

Bgee · 20
ACSF3 → appendix, bone marrow cell, brown adipose tissue, cardiac muscle tissue of left ventricle, corneal stroma, granulocyte, Ileal epithelium, interventricular septum, lactiferous gland, left adrenal cortex, left adrenal gland, left lobe of liver, mucosa of transverse colon, otic vesicle, proximal tubule, right adrenal cortex, right adrenal gland, right kidney, right lobe of liver, sural nerve
RNA expression pattern · 20
ACSF3 → appendix, bone marrow cell, brown adipose tissue, cardiac muscle tissue of left ventricle, corneal stroma, granulocyte, Ileal epithelium, interventricular septum, lactiferous gland, left adrenal cortex, left adrenal gland, left lobe of liver, mucosa of transverse colon, otic vesicle, proximal tubule, right adrenal cortex, right adrenal gland, right kidney, right lobe of liver, sural nerve
Gene ontology · 17
ACSF3 → acid-thiol ligase activity, ATP binding, catalytic activity, fatty acid biosynthetic process, fatty acid metabolic process, ligase activity, lipid metabolism, long-chain fatty-acyl-CoA biosynthetic process, malonate catabolic process, malonyl-CoA synthetase activity, metabolism, methylmalonyl-CoA synthetase activity, mitochondrial matrix, mitochondrion, nucleotide binding, protein malonylation, very long-chain fatty acid-CoA ligase activity
related to Reaction · 15
ACSF3 → Adenylation, AMP, ATP, ATP-dependent, C24, CoA, CoA-SH, Despite, During, Lignoceric, Mg-ATP, Mg2, PPi, The, Thioesterification
related to Degradation of malonic acid · 11
ACSF3 → Additional, By, CoA, Complex II, Exogenous, Malonate, SDH, SLC25A10, TCA, The, Through
related to Degradation of methylmalonic acid · 8
ACSF3 → According, ACSF3-mediated, CoA, Efficient, In, Methylmalonic, SDH, Specifically
related to Combined malonic and methylmalonic aciduria (CMAMMA) · 7
ACSF3 → By, CMAMMA, Other, Pathogenic, Some, The, These
related to Metabolic dysfunction-associated steatotic liver disease (MASLD) · 7
ACSF3 → Deacetylation, Its, MASLD, NAFLD, PCA, SIRT3, The
related to External links · 5
ACSF3 → Human ACSF3, Medicine, This, UCSC Genome Browser, United States National Library
related to Chronic obstructive pulmonary disease (COPD) · 4
ACSF3 → An, COPD, DNA, Furthermore

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Important terminology

acid mitochondrial malonyl-coa methylmalonic methylmalonyl-coa malonic lysine gene acyl-coa fatty synthesis malonate human malonylation activity bp metabolism mouse metabolic synthetase

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ACSF36.2.1.76↗1.00infobox
ACSF3AliasesACSF3, acyl-CoA synthetase family member 31.00infobox
ACSF3Band16q24.31.00infobox
ACSF3Band8|8 E11.00infobox
ACSF3Bgeemucosa of transverse colon1.00infobox
ACSF3Bgeegranulocyte1.00infobox
ACSF3Bgeeright adrenal gland1.00infobox
ACSF3Bgeesural nerve1.00infobox
ACSF3Bgeebone marrow cell1.00infobox
ACSF3Bgeeright adrenal cortex1.00infobox
ACSF3Bgeeleft adrenal gland1.00infobox
ACSF3Bgeeleft adrenal cortex1.00infobox
ACSF3Bgeeright lobe of liver1.00infobox
ACSF3Bgeeappendix1.00infobox
ACSF3BgeeIleal epithelium1.00infobox
ACSF3Bgeeinterventricular septum1.00infobox
ACSF3Bgeecardiac muscle tissue of left ventricle1.00infobox
ACSF3Bgeeright kidney1.00infobox
ACSF3Bgeelactiferous gland1.00infobox
ACSF3Bgeecorneal stroma1.00infobox
ACSF3Bgeebrown adipose tissue1.00infobox
ACSF3Bgeeotic vesicle1.00infobox
ACSF3Bgeeproximal tubule1.00infobox
ACSF3Bgeeleft lobe of liver1.00infobox
ACSF3BioGPSn/a1.00infobox
ACSF3Chr.Chromosome 16 (human)1.00infobox
ACSF3Chr.Chromosome 8 (mouse)1.00infobox
ACSF3DatabasesNCBI: entry; OMA: entry1.00infobox
ACSF3End89,164,121 bp1.00infobox
ACSF3End122,817,880 bp1.00infobox

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