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ACSF3: Reaction, Function & Clinical significance

Acyl-CoA synthetase family member 3 (ACSF3) is a mitochondrial enzyme encoded by the ACSF3 gene. It is required for the degradation of malonic acid and methylmalonic acid and provides the precursor for mitochondrial fatty acid synthesis (mtFAS) and mitochondrial lysine malonylation. The enzyme belongs to the acyl-CoA synthetase family.

Language: English [EN]
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ACSF3 topic overview

The analysis highlights Reaction, Function and Clinical significance as prominent areas in the source structure around ACSF3.

Related topics
145
Source areas
6
Connected nodes
151
Extracted relationships
158
Concept neighborhoods
50
Bridge connections
151

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 48 topics
Function · 29 topics
Clinical significance · 28 topics
Reaction · 22 topics
Structure · 15 topics
Evolutionary role · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

6.2.1.76
Aliases
ACSF3, acyl-CoA synthetase family member 3
Band
16q24.3 · 8|8 E1
Bgee
mucosa of transverse colon · granulocyte · right adrenal gland · sural nerve · bone marrow cell
BioGPS
n/a
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Reaction

Function

Clinical significance

Evolutionary role

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ACSF3 connects Entity context

The extracted context around ACSF3 shows recurring relationship patterns in the source. For example, ACSF3 → appendix, bone marrow cell, brown adipose tissue, cardiac muscle tissue of left ventricle, corneal stroma, granulocyte, Ileal epithelium, interventricular septum, lactiferous gland, left adrenal cortex, left adrenal gland, left lobe of liver, mucosa of transverse colon, otic vesicle, proximal tubule, right adrenal cortex, right adrenal gland, right kidney, right lobe of liver, sural nerve Another extracted example is ACSF3 → acid-thiol ligase activity, ATP binding, catalytic activity, fatty acid biosynthetic process, fatty acid metabolic process, ligase activity, lipid metabolism, long-chain fatty-acyl-CoA biosynthetic process, malonate catabolic process, malonyl-CoA synthetase activity, metabolism, methylmalonyl-CoA synthetase activity, mitochondrial matrix, mitochondrion, nucleotide binding, protein malonylation, very long-chain fatty acid-CoA ligase activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

ACSF3

Top relations

Bgee · 20
ACSF3 → appendix, bone marrow cell, brown adipose tissue, cardiac muscle tissue of left ventricle, corneal stroma, granulocyte, Ileal epithelium, interventricular septum, lactiferous gland, left adrenal cortex, left adrenal gland, left lobe of liver, mucosa of transverse colon, otic vesicle, proximal tubule, right adrenal cortex, right adrenal gland, right kidney, right lobe of liver, sural nerve
RNA expression pattern · 20
ACSF3 → appendix, bone marrow cell, brown adipose tissue, cardiac muscle tissue of left ventricle, corneal stroma, granulocyte, Ileal epithelium, interventricular septum, lactiferous gland, left adrenal cortex, left adrenal gland, left lobe of liver, mucosa of transverse colon, otic vesicle, proximal tubule, right adrenal cortex, right adrenal gland, right kidney, right lobe of liver, sural nerve
Gene ontology · 17
ACSF3 → acid-thiol ligase activity, ATP binding, catalytic activity, fatty acid biosynthetic process, fatty acid metabolic process, ligase activity, lipid metabolism, long-chain fatty-acyl-CoA biosynthetic process, malonate catabolic process, malonyl-CoA synthetase activity, metabolism, methylmalonyl-CoA synthetase activity, mitochondrial matrix, mitochondrion, nucleotide binding, protein malonylation, very long-chain fatty acid-CoA ligase activity
related to Reaction · 15
ACSF3 → Adenylation, AMP, ATP, ATP-dependent, C24, CoA, CoA-SH, Despite, During, Lignoceric, Mg-ATP, Mg2, PPi, The, Thioesterification
related to Degradation of malonic acid · 11
ACSF3 → Additional, By, CoA, Complex II, Exogenous, Malonate, SDH, SLC25A10, TCA, The, Through
related to Degradation of methylmalonic acid · 8
ACSF3 → According, ACSF3-mediated, CoA, Efficient, In, Methylmalonic, SDH, Specifically
related to Combined malonic and methylmalonic aciduria (CMAMMA) · 7
ACSF3 → By, CMAMMA, Other, Pathogenic, Some, The, These
related to Metabolic dysfunction-associated steatotic liver disease (MASLD) · 7
ACSF3 → Deacetylation, Its, MASLD, NAFLD, PCA, SIRT3, The
related to External links · 5
ACSF3 → Human ACSF3, Medicine, This, UCSC Genome Browser, United States National Library
related to Chronic obstructive pulmonary disease (COPD) · 4
ACSF3 → An, COPD, DNA, Furthermore

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

acid mitochondrial malonyl-coa methylmalonic methylmalonyl-coa malonic lysine gene acyl-coa fatty synthesis malonate human malonylation activity bp metabolism mouse metabolic synthetase

ACSF3 relationships Subject–Predicate–Object triples

TTTA extracted 158 structured relationships around ACSF3. Examples in this analysis include ACSF3 → 6.2.1.76 → ↗ and ACSF3 → Aliases → ACSF3, acyl-CoA synthetase family member 3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ACSF36.2.1.761.00infobox
ACSF3AliasesACSF3, acyl-CoA synthetase family member 31.00infobox
ACSF3Band16q24.31.00infobox
ACSF3Band8|8 E11.00infobox
ACSF3Bgeemucosa of transverse colon1.00infobox
ACSF3Bgeegranulocyte1.00infobox
ACSF3Bgeeright adrenal gland1.00infobox
ACSF3Bgeesural nerve1.00infobox
ACSF3Bgeebone marrow cell1.00infobox
ACSF3Bgeeright adrenal cortex1.00infobox
ACSF3Bgeeleft adrenal gland1.00infobox
ACSF3Bgeeleft adrenal cortex1.00infobox
ACSF3Bgeeright lobe of liver1.00infobox
ACSF3Bgeeappendix1.00infobox
ACSF3BgeeIleal epithelium1.00infobox
ACSF3Bgeeinterventricular septum1.00infobox
ACSF3Bgeecardiac muscle tissue of left ventricle1.00infobox
ACSF3Bgeeright kidney1.00infobox
ACSF3Bgeelactiferous gland1.00infobox
ACSF3Bgeecorneal stroma1.00infobox
ACSF3Bgeebrown adipose tissue1.00infobox
ACSF3Bgeeotic vesicle1.00infobox
ACSF3Bgeeproximal tubule1.00infobox
ACSF3Bgeeleft lobe of liver1.00infobox
ACSF3BioGPSn/a1.00infobox
ACSF3Chr.Chromosome 16 (human)1.00infobox
ACSF3Chr.Chromosome 8 (mouse)1.00infobox
ACSF3DatabasesNCBI: entry; OMA: entry1.00infobox
ACSF3End89,164,121 bp1.00infobox
ACSF3End122,817,880 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ACSF3 bring nearby vocabulary together. In this analysis, examples include Malonyl-coa, Mitochondrial and Acid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ACSF3
    • Malonyl-coa
    • Mitochondrial
    • Acid
    • Methylmalonyl-coa
    • Gene
    • Metabolic
    • Methylmalonic
    • Malonate
    • Malonic
    • Activity
    • Role
    • Accumulation
  • acsf3
    • Malonyl-coa
    • Mitochondrial
    • Acid
    • Methylmalonyl-coa
    • Gene
    • Metabolic
    • Methylmalonic
    • Malonate
    • Malonic
    • Activity
    • Role
    • Accumulation
  • mitochondrial
    • Acid
    • Fatty
    • Malonyl-coa
    • Malonylation
    • Synthesis
    • Malonic
    • Methylmalonic
    • Lysine
    • Required
    • Mouse
    • Activity
    • Metabolism
  • enzyme
    • Family
    • Synthetase
    • Gene
    • Chromosome
    • Degradation
    • Function
    • Liver
    • Location
    • Role
    • Succinyl-coa
    • Acetyl-coa
    • Bp
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • Synthetase
    • Metabolic
    • Band
    • Function
    • Liver
    • Role
    • Cmamma
  • malonic acid
    • Methylmalonic
    • Acid
    • Malonic
    • Mitochondrial
    • Malonyl-coa
    • Acsf3
    • Cmamma
    • Fatty
    • Role
    • Acetyl-coa
    • Metabolism
    • Metabolic
  • methylmalonic acid
    • Methylmalonic
    • Malonic
    • Mitochondrial
    • Malonyl-coa
    • Acsf3
    • Cmamma
    • Fatty
    • Metabolism
    • Accumulation
    • Methylmalonyl-coa
    • Metabolic
    • Mouse
  • mitochondrial fatty acid synthesis
    • Synthesis
    • Methylmalonic
    • Malonic
    • Acid
    • Mitochondrial
    • Malonylation
    • Liver
    • Malonyl-coa
    • Acsf3
    • Fatty
    • Activity
    • Chromosome

Connections between topic areas Semantic bridges

For ACSF3, one of the stronger structural bridges in this analysis connects ACSF3 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ACSF3Overview · splits 103 ⟂ 49
ACSF3Function · splits 122 ⟂ 30
ACSF3Clinical significance · splits 123 ⟂ 29
ACSF3Reaction · splits 129 ⟂ 23
ACSF3Structure · splits 136 ⟂ 16
ACSF3Evolutionary role · splits 148 ⟂ 4

Map overview Semantic statistics

ACSF3

Nodes152
Edges151
Triples158
Avg. degree1.99
Density0.013158
Components1

Source & methodology

TTTA analyzes the structure around ACSF3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Reaction, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ACSF3 · EN edition · Analysis: TopicsToTalkAbout

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