Peroxisome proliferator-activated receptor gamma

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Explore the main themes, entities and connections around Peroxisome proliferator-activated receptor gamma. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Adipogenesis Knockout mice Lipotoxicity Adiponectin FGF21

22 related topics

Interactions

Interact Tetrahydrocannabivarin Cannabidiol Anandamide CD36

13 related topics

Gene expression

Peroxisome proliferator-activated receptor Retinoid X receptors PPAR-alpha PPAR-delta Adipocyte

7 related topics

Research

Agonists Hyperlipidaemia Hyperglycemia Insulin sensitizing drugs Thiazolidinediones

7 related topics

Key facts & relationships

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Aliases: PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP,…
Band: 3p25.2 · 6 E3|6 53.41 cM
Bgee: mucosa of transverse colon · subcutaneous adipose tissue · rectum · epithelium of colon · mucosa of sigmoid colon
BioGPS: More reference expression data
Chr.: Chromosome 3 (human) · Chromosome 6 (mouse)

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Overview

Tissue distribution

Adipose tissue

Gene expression

Peroxisome proliferator-activated receptor
Retinoid X receptors Retinoid X receptor
PPAR-alpha Peroxisome proliferator-activated receptor alpha
PPAR-delta Peroxisome proliferator-activated receptor delta
Adipocyte
Alternatively spliced Alternative splicing
Isoforms Protein isoform

Function

Adipogenesis
Knockout mice Knockout mouse
Lipotoxicity
Adiponectin
FGF21
Nicotinic acid adenine dinucleotide phosphate
Upregulation Downregulation and upregulation
CD38
M2 macrophage Macrophage polarization
ABCA1
Reverse cholesterol transport
LXRα/β Liver X receptor
Polyunsaturated fatty acids
Arachidonic acid
5-hydroxyicosatetraenoic acid
5-oxo-eicosatetraenoic acid
15-hydroxyicosatetraenoic acid
Phytocannabinoid Cannabinoid
Tetrahydrocannabinol
THC-COOH 11-Nor-9-carboxy-THC
Synthetic Synthetic cannabinoids
Ajulemic acid

Interactions

Interact Protein-protein interaction
Tetrahydrocannabivarin
Cannabidiol
Anandamide
CD36
EDF1
EP300
HDAC3
NCOA4
NR0B2 Small heterodimer partner
PPARGC1A
RB1 Retinoblastoma protein
MiR3666 MiR3666?action=edit&redlink=1

Research

Agonists Agonist
Hyperlipidaemia
Hyperglycemia
Insulin sensitizing drugs Anti-diabetic drug
Thiazolidinediones
Diabetes
Insulin resistance

Advanced semantic analysis

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Map overview Semantic statistics

Peroxisome proliferator-activated receptor gamma

Nodes60

Edges59

Triples195

Avg. degree1.97

Density0.033333

Components1

How this topic connects Entity context

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Peroxisome proliferator-activated receptor gamma

Top relations

Gene ontology · 128

Peroxisome proliferator-activated receptor gamma → activation of cysteine-type endopeptidase activity involved in apoptotic process, alpha-actinin binding, animal organ regeneration, arachidonic acid binding, cell differentiation, cell fate commitment, cell maturation, cellular response to hyperoxia, cellular response to insulin stimulus, cellular response to low-density lipoprotein particle stimulus, cellular response to prostaglandin E stimulus, cellular response to prostaglandin stimulus, cellular response to retinoic acid, cellular response to vitamin E, chromatin binding, core promoter sequence-specific DNA binding, cytoplasm, cytosol, development of the heart, DNA binding

Bgee · 19

Peroxisome proliferator-activated receptor gamma → Achilles tendon, brown adipose tissue, epithelium of colon, epithelium of stomach, gonad, mammary gland, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, pyloric antrum, rectum, right lung, secondary oocyte, subcutaneous adipose tissue, testicle, transitional epithelium of urinary bladder, tunica adventitia of aorta, urinary bladder, white adipose tissue

RNA expression pattern · 19

Band · 2

Peroxisome proliferator-activated receptor gamma → 3p25.2, 6 E3|6 53.41 cM

Chr. · 2

Peroxisome proliferator-activated receptor gamma → Chromosome 3 (human), Chromosome 6 (mouse)

End · 2

Peroxisome proliferator-activated receptor gamma → 115,467,360 bp, 12,434,356 bp

related to Interactions · 2

Peroxisome proliferator-activated receptor gamma → Peroxisome, TetrahydrocannabivarinCannabidiolAnandamideCD36EDF1EP300HDAC3NCOA4NR0B2PPARGC1ARB1

Aliases · 1

Peroxisome proliferator-activated receptor gamma → PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5

Available structures · 1

Peroxisome proliferator-activated receptor gamma → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP,…

BioGPS · 1

Peroxisome proliferator-activated receptor gamma → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pparg gene human bp insulin chr band tissue mice peroxisome receptor gamma chromosome mouse activation placenta also adipose acid fatty

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Peroxisome proliferator-activated receptor gamma	Aliases	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP,…	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Band	3p25.2	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Band	6 E3\|6 53.41 cM	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	mucosa of transverse colon	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	subcutaneous adipose tissue	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	rectum	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	epithelium of colon	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	mucosa of sigmoid colon	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	right lung	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	testicle	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	urinary bladder	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	gonad	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	Achilles tendon	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	brown adipose tissue	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	transitional epithelium of urinary bladder	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	white adipose tissue	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	mucous cell of stomach	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	tunica adventitia of aorta	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	epithelium of stomach	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	pyloric antrum	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	secondary oocyte	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	mammary gland	1.00	infobox
Peroxisome proliferator-activated receptor gamma	BioGPS	More reference expression data	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Chr.	Chromosome 3 (human)	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Chr.	Chromosome 6 (mouse)	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Databases	NCBI: entry; OMA: entry	1.00	infobox
Peroxisome proliferator-activated receptor gamma	End	12,434,356 bp	1.00	infobox
Peroxisome proliferator-activated receptor gamma	End	115,467,360 bp	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Ensembl	ENSG00000132170	1.00	infobox

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