FBXW7

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around FBXW7. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Function

F-box protein Ubiquitin protein ligase complex WD40 domains Leucine-rich repeats Protein-protein interaction modules

7 related topics

Interactions

Interact MYB PPARGC1A Parkin (ligase)SKP1A

5 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: FBXW7, AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4, F-box and WD repeat domain containing 7
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2OVP, 2OVQ, 2OVR, 5IBK
Band: 4q31.3 · 3 F1|3 37.7 cM
Bgee: Brodmann area 23 · Achilles tendon · epithelium of colon · middle temporal gyrus · superior frontal gyrus
BioGPS: More reference expression data
Chr.: Chromosome 4 (human) · Chromosome 3 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Function

F-box protein
Ubiquitin protein ligase complex Ubiquitin ligase
WD40 domains WD40 domain
Leucine-rich repeats Leucine-rich repeat
Protein-protein interaction modules Protein-protein interaction module
Cyclin E
NF-κB

Interactions

Interact Protein-protein interaction
MYB MYB (gene)
PPARGC1A
Parkin (ligase)
SKP1A

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes18

Edges17

Triples148

Avg. degree1.89

Density0.111111

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

FBXW7

Top relations

Gene ontology · 60

FBXW7 → cellular response to DNA damage stimulus, cellular response to UV, cyclin binding, cytoplasm, cytosol, endoplasmic reticulum, Golgi apparatus, identical protein binding, lipid homeostasis, lung development, mitochondrion, negative regulation of DNA endoreduplication, negative regulation of gene expression, negative regulation of hepatocyte proliferation, negative regulation of Notch signaling pathway, negative regulation of osteoclast development, negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding, negative regulation of SREBP signaling pathway, negative regulation of triglyceride biosynthetic process, Notch signaling pathway

related to Function · 26

FBXW7 → AML, C/EBPα, Despite, F-box, Fbls, Fbws, FBX30, Fbxs, FBXW7-mediated, For, IκBd, Mono-allelic, Myc, NF-κB, Notch1, One, Other, SCFs, SKP1-cullin-F-box, T-ALL

Bgee · 18

FBXW7 → Achilles tendon, amygdala, barrel cortex, Brodmann area 23, epithelium of colon, middle temporal gyrus, occipital lobe, parietal lobe, pons, postcentral gyrus, prefrontal cortex, primary motor cortex, primary visual cortex, Region I of hippocampus proper, saccule, superior frontal gyrus, temporal lobe, visual cortex

RNA expression pattern · 18

related to Interactions · 3

FBXW7 → MYB, Parkin, PPARGC1A

Band · 2

FBXW7 → 3 F1|3 37.7 cM, 4q31.3

Chr. · 2

FBXW7 → Chromosome 3 (mouse), Chromosome 4 (human)

End · 2

FBXW7 → 152,536,092 bp, 84,886,505 bp

Aliases · 1

FBXW7 → FBXW7, AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4, F-box and WD repeat domain containing 7

Available structures · 1

FBXW7 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2OVP, 2OVQ, 2OVR, 5IBK

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp human protein f-box chr band chromosome location function mouse ligase cell wd cancers encoded search 536 092 end

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
FBXW7	Aliases	FBXW7, AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4, F-box and WD repeat domain containing 7	1.00	infobox
FBXW7	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2OVP, 2OVQ, 2OVR, 5IBK	1.00	infobox
FBXW7	Band	4q31.3	1.00	infobox
FBXW7	Band	3 F1\|3 37.7 cM	1.00	infobox
FBXW7	Bgee	Brodmann area 23	1.00	infobox
FBXW7	Bgee	Achilles tendon	1.00	infobox
FBXW7	Bgee	epithelium of colon	1.00	infobox
FBXW7	Bgee	middle temporal gyrus	1.00	infobox
FBXW7	Bgee	superior frontal gyrus	1.00	infobox
FBXW7	Bgee	occipital lobe	1.00	infobox
FBXW7	Bgee	pons	1.00	infobox
FBXW7	Bgee	parietal lobe	1.00	infobox
FBXW7	Bgee	primary visual cortex	1.00	infobox
FBXW7	Bgee	postcentral gyrus	1.00	infobox
FBXW7	Bgee	prefrontal cortex	1.00	infobox
FBXW7	Bgee	primary motor cortex	1.00	infobox
FBXW7	Bgee	barrel cortex	1.00	infobox
FBXW7	Bgee	visual cortex	1.00	infobox
FBXW7	Bgee	temporal lobe	1.00	infobox
FBXW7	Bgee	amygdala	1.00	infobox
FBXW7	Bgee	saccule	1.00	infobox
FBXW7	Bgee	Region I of hippocampus proper	1.00	infobox
FBXW7	BioGPS	More reference expression data	1.00	infobox
FBXW7	Chr.	Chromosome 4 (human)	1.00	infobox
FBXW7	Chr.	Chromosome 3 (mouse)	1.00	infobox
FBXW7	Databases	NCBI: entry; OMA: entry	1.00	infobox
FBXW7	End	152,536,092 bp	1.00	infobox
FBXW7	End	84,886,505 bp	1.00	infobox
FBXW7	Ensembl	ENSG00000109670	1.00	infobox
FBXW7	Entrez	55294	1.00	infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3