SCN5A

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

SCN5A topic overview

The analysis highlights Measurement, Genetics and Gene structure as prominent areas in the source structure around SCN5A.

Related topics: 57
Source areas: 5
Connected nodes: 62
Extracted relationships: 182
Concept neighborhoods: 25
Bridge connections: 62

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Genetics · 18 topics

Gene structure · 16 topics

Overview · 10 topics

Protein structure and function · 10 topics

NaV1.5 as a pharmacological target · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1, sodium voltage-gated channel alpha subunit 5
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KBI, 2L53, 4DCK, 4DJC, 4JQ0, 4OVN
Band: 3p22.2 · 9 F3|9 71.33 cM
Bgee: apex of heart · left ventricle · right auricle of heart · myocardium of left ventricle · right ventricle
BioGPS: n/a
Chr.: Chromosome 3 (human) · Chromosome 9 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Integral membrane protein
Tetrodotoxin
Sodium channel
Cardiac muscle
Cell membrane
Depolarization
Cardiac action potential
Impulse propagation through the heart Electrical conduction system of the heart
Genetics SCN5A
Gene

Gene structure

Protein structure and function

Genetics

Brugada syndrome
Lev-Lenègre disease Lev's disease
DCM Dilated cardiomyopathy
Sick sinus syndrome
Long QT syndrome type 3 Long QT syndrome
AF Atrial fibrillation
Irritable Bowel Syndrome
Smooth muscle Smooth muscle tissue
Colon Large intestine
Mexiletine
Abdominal pain
Single nucleotide polymorphisms Single-nucleotide polymorphism
GWAS Genome-wide association study
Loci Locus (genetics)
Electrocardiographic parameters Electrocardiography
PR- PR interval
QRS- QRS complex
QTc-interval duration QT interval

NaV1.5 as a pharmacological target

Pharmacologic treatment Pharmacology
Sodium channel blockers Sodium channel blocker
Ventricular reentrant tachyarrhythmia Ventricular tachycardia

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SCN5A connects Entity context

The extracted context around SCN5A shows recurring relationship patterns in the source. For example, SCN5A → ankyrin binding, atrial cardiac muscle cell action potential, AV node cell action potential, AV node cell to bundle of His cell communication, axon, brainstem development, bundle of His cell action potential, calmodulin binding, cardiac conduction, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, cardiac ventricle development, caveola, cell surface, cellular response to calcium ion, cerebellum development, cytoplasm, endoplasmic reticulum, enzyme binding, fibroblast growth factor binding Another extracted example is SCN5A → apex of heart, atrioventricular valve, atrium, cardiac muscle tissue of right atrium, cardiac muscles, endothelial cell of lymphatic vessel, gonad, left ventricle, Meckel's cartilage, myocardium of left ventricle, myocardium of ventricle, olfactory epithelium, rib, right auricle of heart, right ventricle, scapula, secondary oocyte, sural nerve, testicle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 77

SCN5A → ankyrin binding, atrial cardiac muscle cell action potential, AV node cell action potential, AV node cell to bundle of His cell communication, axon, brainstem development, bundle of His cell action potential, calmodulin binding, cardiac conduction, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, cardiac ventricle development, caveola, cell surface, cellular response to calcium ion, cerebellum development, cytoplasm, endoplasmic reticulum, enzyme binding, fibroblast growth factor binding

Bgee · 19

SCN5A → apex of heart, atrioventricular valve, atrium, cardiac muscle tissue of right atrium, cardiac muscles, endothelial cell of lymphatic vessel, gonad, left ventricle, Meckel's cartilage, myocardium of left ventricle, myocardium of ventricle, olfactory epithelium, rib, right auricle of heart, right ventricle, scapula, secondary oocyte, sural nerve, testicle

RNA expression pattern · 19

related to External links · 13

SCN5A → Brugada, GeneReviews/NIH/NCBI/UW, Medicine Medical Subject Headings, MeSH, National Library, NIH/NCBI/UW, Overview, PDB, PDBe-KB, Q14524, Romano-Ward SyndromeSCN5A, Sodium, UniProt

related to SCN5A variations in the general population · 12

SCN5A → Genetic, Genome Wide Association Studies, GWAS, In, PR, PR-interval, QRS, QTc-interval, SCN5A-SCN10A, SNPs, The, These

related to Genetics · 8

SCN5A → Also, BrS, Brugada, DCM, Lev-Lenègre, Mutations, Pathogenic, To

related to Gene structure · 4

SCN5A → NaV1, RNA, The, UTR

related to Splice variants · 3

SCN5A → In, More, Moreover

Band · 2

SCN5A → 3p22.2, 9 F3|9 71.33 cM

Chr. · 2

SCN5A → Chromosome 3 (human), Chromosome 9 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nav1 cardiac sodium channel gene also channels mutations potential heart human protein bp membrane action function chromosome general chr band

SCN5A relationships Subject–Predicate–Object triples

TTTA extracted 182 structured relationships around SCN5A. Examples in this analysis include SCN5A → Aliases → SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1, sodium voltage-gated channel alpha subunit 5 and SCN5A → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KBI, 2L53, 4DCK, 4DJC, 4JQ0, 4OVN. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
SCN5A	Aliases	SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1, sodium voltage-gated channel alpha subunit 5	1.00	infobox
SCN5A	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KBI, 2L53, 4DCK, 4DJC, 4JQ0, 4OVN	1.00	infobox
SCN5A	Band	3p22.2	1.00	infobox
SCN5A	Band	9 F3\|9 71.33 cM	1.00	infobox
SCN5A	Bgee	apex of heart	1.00	infobox
SCN5A	Bgee	left ventricle	1.00	infobox
SCN5A	Bgee	right auricle of heart	1.00	infobox
SCN5A	Bgee	myocardium of left ventricle	1.00	infobox
SCN5A	Bgee	right ventricle	1.00	infobox
SCN5A	Bgee	cardiac muscle tissue of right atrium	1.00	infobox
SCN5A	Bgee	testicle	1.00	infobox
SCN5A	Bgee	gonad	1.00	infobox
SCN5A	Bgee	secondary oocyte	1.00	infobox
SCN5A	Bgee	sural nerve	1.00	infobox
SCN5A	Bgee	myocardium of ventricle	1.00	infobox
SCN5A	Bgee	atrium	1.00	infobox
SCN5A	Bgee	Meckel's cartilage	1.00	infobox
SCN5A	Bgee	rib	1.00	infobox
SCN5A	Bgee	olfactory epithelium	1.00	infobox
SCN5A	Bgee	scapula	1.00	infobox
SCN5A	Bgee	cardiac muscles	1.00	infobox
SCN5A	Bgee	atrioventricular valve	1.00	infobox
SCN5A	Bgee	endothelial cell of lymphatic vessel	1.00	infobox
SCN5A	BioGPS	n/a	1.00	infobox
SCN5A	Chr.	Chromosome 3 (human)	1.00	infobox
SCN5A	Chr.	Chromosome 9 (mouse)	1.00	infobox
SCN5A	Databases	NCBI: entry; OMA: entry	1.00	infobox
SCN5A	End	38,649,687 bp	1.00	infobox
SCN5A	End	119,408,082 bp	1.00	infobox
SCN5A	Ensembl	ENSG00000183873	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SCN5A bring nearby vocabulary together. In this analysis, examples include Expression, Sodium and Expressed. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

integral membrane protein
- Cell
- Voltage-gated
- Potential
- Human
- Sodium
- Action
- Function
- Channels
- Muscle
- See
- Type
- Nav1
sodium channel
- Sodium
- Cardiac
- Protein
- Scn5a
- Nav1
- Voltage-gated
- Current
- Human
- Muscle
- Action
- Gene
- Function
cardiac muscle
- Sodium
- Channel
- Resulting
- Cell
- Associated
- Nav1
- Action
- Function
- Scn5a
- Diseases
- Muscle
- Potential
cell membrane
- Cell
- Membrane
- Potential
- Action
- Muscle
- Voltage-gated
- Channels
- Conduction
- Nav1
- Function
- Protein
- Band
cardiac action potential
- Potential
- Sodium
- Cell
- Channel
- Current
- Membrane
- Associated
- Nav1
- Ina
- Muscle
- Scn5a
- Channels
gene
- Bp
- Chr
- Chromosome
- Human
- Voltage-gated
- Scn5a
- Band
- Expression
- Population
- Sodium
- Function
- General
nav1.1
- Function
- Sodium
- Cardiac
- Channels
- Membrane
- Protein
- See
- Ina
- Muscle
- Resulting
- Cell
- Scn5a
nav1.2
- Function
- Sodium
- Cardiac
- Channels
- Membrane
- Protein
- See
- Ina
- Muscle
- Resulting
- Cell
- Scn5a

Connections between topic areas Semantic bridges

For SCN5A, one of the stronger structural bridges in this analysis connects SCN5A with Genetics. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

SCN5A — Genetics · splits 44 ⟂ 19

SCN5A — Gene structure · splits 46 ⟂ 17

SCN5A — Overview · splits 52 ⟂ 11

SCN5A — Protein structure and function · splits 52 ⟂ 11

SCN5A — NaV1.5 as a pharmacological target · splits 59 ⟂ 4

Map overview Semantic statistics

SCN5A

Nodes63

Edges62

Triples182

Avg. degree1.97

Density0.031746

Components1

Source & methodology

TTTA analyzes the structure around SCN5A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Genetics & Gene structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SCN5A · EN edition · Analysis: TopicsToTalkAbout