SCN5A

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Explore the main themes, entities and connections around SCN5A. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Genetics

Brugada syndrome Lev-Lenègre disease DCM Sick sinus syndrome Long QT syndrome type 3

18 related topics

Gene structure

Exons 5’UTR 3’UTR NaV1.1 NaV1.2

16 related topics

Protein structure and function

Transmembrane protein Transmembrane domains SCN1B SCN2B SCN3B

10 related topics

NaV1.5 as a pharmacological target

Pharmacologic treatment Sodium channel blockers Ventricular reentrant tachyarrhythmia

3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1, sodium voltage-gated channel alpha subunit 5
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KBI, 2L53, 4DCK, 4DJC, 4JQ0, 4OVN
Band: 3p22.2 · 9 F3|9 71.33 cM
Bgee: apex of heart · left ventricle · right auricle of heart · myocardium of left ventricle · right ventricle
BioGPS: n/a
Chr.: Chromosome 3 (human) · Chromosome 9 (mouse)

Topics to explore

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Overview

Integral membrane protein
Tetrodotoxin
Sodium channel
Cardiac muscle
Cell membrane
Depolarization
Cardiac action potential
Impulse propagation through the heart Electrical conduction system of the heart
Genetics SCN5A
Gene

Gene structure

Protein structure and function

Genetics

Brugada syndrome
Lev-Lenègre disease Lev's disease
DCM Dilated cardiomyopathy
Sick sinus syndrome
Long QT syndrome type 3 Long QT syndrome
AF Atrial fibrillation
Irritable Bowel Syndrome
Smooth muscle Smooth muscle tissue
Colon Large intestine
Mexiletine
Abdominal pain
Single nucleotide polymorphisms Single-nucleotide polymorphism
GWAS Genome-wide association study
Loci Locus (genetics)
Electrocardiographic parameters Electrocardiography
PR- PR interval
QRS- QRS complex
QTc-interval duration QT interval

NaV1.5 as a pharmacological target

Pharmacologic treatment Pharmacology
Sodium channel blockers Sodium channel blocker
Ventricular reentrant tachyarrhythmia Ventricular tachycardia

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes63

Edges62

Triples182

Avg. degree1.97

Density0.031746

Components1

How this topic connects Entity context

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SCN5A

Top relations

Gene ontology · 77

SCN5A → ankyrin binding, atrial cardiac muscle cell action potential, AV node cell action potential, AV node cell to bundle of His cell communication, axon, brainstem development, bundle of His cell action potential, calmodulin binding, cardiac conduction, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, cardiac ventricle development, caveola, cell surface, cellular response to calcium ion, cerebellum development, cytoplasm, endoplasmic reticulum, enzyme binding, fibroblast growth factor binding

Bgee · 19

SCN5A → apex of heart, atrioventricular valve, atrium, cardiac muscle tissue of right atrium, cardiac muscles, endothelial cell of lymphatic vessel, gonad, left ventricle, Meckel's cartilage, myocardium of left ventricle, myocardium of ventricle, olfactory epithelium, rib, right auricle of heart, right ventricle, scapula, secondary oocyte, sural nerve, testicle

RNA expression pattern · 19

related to External links · 13

SCN5A → Brugada, GeneReviews/NIH/NCBI/UW, Medicine Medical Subject Headings, MeSH, National Library, NIH/NCBI/UW, Overview, PDB, PDBe-KB, Q14524, Romano-Ward SyndromeSCN5A, Sodium, UniProt

related to SCN5A variations in the general population · 12

SCN5A → Genetic, Genome Wide Association Studies, GWAS, In, PR, PR-interval, QRS, QTc-interval, SCN5A-SCN10A, SNPs, The, These

related to Genetics · 8

SCN5A → Also, BrS, Brugada, DCM, Lev-Lenègre, Mutations, Pathogenic, To

related to Gene structure · 4

SCN5A → NaV1, RNA, The, UTR

related to Splice variants · 3

SCN5A → In, More, Moreover

Band · 2

SCN5A → 3p22.2, 9 F3|9 71.33 cM

Chr. · 2

SCN5A → Chromosome 3 (human), Chromosome 9 (mouse)

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nav1 cardiac sodium channel gene also channels mutations potential heart human protein bp membrane action function chromosome general chr band

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
SCN5A	Aliases	SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1, sodium voltage-gated channel alpha subunit 5	1.00	infobox
SCN5A	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KBI, 2L53, 4DCK, 4DJC, 4JQ0, 4OVN	1.00	infobox
SCN5A	Band	3p22.2	1.00	infobox
SCN5A	Band	9 F3\|9 71.33 cM	1.00	infobox
SCN5A	Bgee	apex of heart	1.00	infobox
SCN5A	Bgee	left ventricle	1.00	infobox
SCN5A	Bgee	right auricle of heart	1.00	infobox
SCN5A	Bgee	myocardium of left ventricle	1.00	infobox
SCN5A	Bgee	right ventricle	1.00	infobox
SCN5A	Bgee	cardiac muscle tissue of right atrium	1.00	infobox
SCN5A	Bgee	testicle	1.00	infobox
SCN5A	Bgee	gonad	1.00	infobox
SCN5A	Bgee	secondary oocyte	1.00	infobox
SCN5A	Bgee	sural nerve	1.00	infobox
SCN5A	Bgee	myocardium of ventricle	1.00	infobox
SCN5A	Bgee	atrium	1.00	infobox
SCN5A	Bgee	Meckel's cartilage	1.00	infobox
SCN5A	Bgee	rib	1.00	infobox
SCN5A	Bgee	olfactory epithelium	1.00	infobox
SCN5A	Bgee	scapula	1.00	infobox
SCN5A	Bgee	cardiac muscles	1.00	infobox
SCN5A	Bgee	atrioventricular valve	1.00	infobox
SCN5A	Bgee	endothelial cell of lymphatic vessel	1.00	infobox
SCN5A	BioGPS	n/a	1.00	infobox
SCN5A	Chr.	Chromosome 3 (human)	1.00	infobox
SCN5A	Chr.	Chromosome 9 (mouse)	1.00	infobox
SCN5A	Databases	NCBI: entry; OMA: entry	1.00	infobox
SCN5A	End	38,649,687 bp	1.00	infobox
SCN5A	End	119,408,082 bp	1.00	infobox
SCN5A	Ensembl	ENSG00000183873	1.00	infobox

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