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Melanocortin 1 receptor

The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms of…

Functions, Pigmentation genetics & Evolution

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Aliases
MC1R, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor
Band
16q24.3 · 8 E1|8 72.1 cM
Bgee
granulocyte · right uterine tube · left testis · right hemisphere of cerebellum · anterior pituitary
BioGPS
n/a
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Functions

Ligands

Pigmentation genetics

Evolution

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Melanocortin 1 receptor

Nodes134
Edges133
Triples92
Avg. degree1.99
Density0.014925
Components1

How this topic connects Entity context

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Melanocortin 1 receptor

Top relations

Gene ontology · 28
Melanocortin 1 receptor → adenylate cyclase-activating G protein-coupled receptor signaling pathway, G protein-coupled peptide receptor activity, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, intracellular signal transduction, melanin biosynthetic process, melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, membrane, multicellular organism development, negative regulation of tumor necrosis factor production, pigmentation, plasma membrane, positive regulation of protein kinase A signaling, positive regulation of protein kinase B signaling, positive regulation of protein kinase C signaling
Bgee · 19
Melanocortin 1 receptor → anterior pituitary, cornea, embryo, epithelium of lens, gastric mucosa, granulocyte, hair follicle, Ileal epithelium, iris, left lobe of thyroid gland, left ovary, left testis, neural layer of retina, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, skin of abdomen, yolk sac
RNA expression pattern · 19
Melanocortin 1 receptor → anterior pituitary, cornea, embryo, epithelium of lens, gastric mucosa, granulocyte, hair follicle, Ileal epithelium, iris, left lobe of thyroid gland, left ovary, left testis, neural layer of retina, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, skin of abdomen, yolk sac
Band · 2
Melanocortin 1 receptor → 16q24.3, 8 E1|8 72.1 cM
Chr. · 2
Melanocortin 1 receptor → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
Melanocortin 1 receptor → 124,137,483 bp, 89,920,973 bp
Aliases · 1
Melanocortin 1 receptor → MC1R, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor
BioGPS · 1
Melanocortin 1 receptor → n/a
Databases · 1
Melanocortin 1 receptor → NCBI: entry; OMA: entry
Ensembl · 1
Melanocortin 1 receptor → ENSG00000258839

Important terminology Word statistics

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Important terminology

mc1r skin receptor hair gene human red humans bp pigment also pain one reported melanocortin known chr melanin band cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Melanocortin 1 receptorAliasesMC1R, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor1.00infobox
Melanocortin 1 receptorBand16q24.31.00infobox
Melanocortin 1 receptorBand8 E1|8 72.1 cM1.00infobox
Melanocortin 1 receptorBgeegranulocyte1.00infobox
Melanocortin 1 receptorBgeeright uterine tube1.00infobox
Melanocortin 1 receptorBgeeleft testis1.00infobox
Melanocortin 1 receptorBgeeright hemisphere of cerebellum1.00infobox
Melanocortin 1 receptorBgeeanterior pituitary1.00infobox
Melanocortin 1 receptorBgeeright testis1.00infobox
Melanocortin 1 receptorBgeegastric mucosa1.00infobox
Melanocortin 1 receptorBgeeleft lobe of thyroid gland1.00infobox
Melanocortin 1 receptorBgeeright lobe of thyroid gland1.00infobox
Melanocortin 1 receptorBgeeleft ovary1.00infobox
Melanocortin 1 receptorBgeehair follicle1.00infobox
Melanocortin 1 receptorBgeeIleal epithelium1.00infobox
Melanocortin 1 receptorBgeeiris1.00infobox
Melanocortin 1 receptorBgeeembryo1.00infobox
Melanocortin 1 receptorBgeeneural layer of retina1.00infobox
Melanocortin 1 receptorBgeeepithelium of lens1.00infobox
Melanocortin 1 receptorBgeeskin of abdomen1.00infobox
Melanocortin 1 receptorBgeeyolk sac1.00infobox
Melanocortin 1 receptorBgeecornea1.00infobox
Melanocortin 1 receptorBioGPSn/a1.00infobox
Melanocortin 1 receptorChr.Chromosome 16 (human)1.00infobox
Melanocortin 1 receptorChr.Chromosome 8 (mouse)1.00infobox
Melanocortin 1 receptorDatabasesNCBI: entry; OMA: entry1.00infobox
Melanocortin 1 receptorEnd89,920,973 bp1.00infobox
Melanocortin 1 receptorEnd124,137,483 bp1.00infobox
Melanocortin 1 receptorEnsemblENSG000002588391.00infobox
Melanocortin 1 receptorEntrez41571.00infobox

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