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Afamelanotide: History, Adverse effects & Pharmacology

Afamelanotide, sold under the brand name Scenesse, is a medication used to prevent phototoxicity and to reduce pain from light exposure for people with erythropoietic protoporphyria, a rare form of genetic sun sensitivity. Afamelanotide is a melanocortin 1 receptor (MC1 receptor) agonist and a synthetic peptide and analogue of α-melanocyte stimulating…

Language: English [EN]
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Afamelanotide topic overview

The analysis highlights History, Adverse effects and Pharmacology as prominent areas in the source structure around Afamelanotide.

Related topics
71
Source areas
5
Connected nodes
76
Extracted relationships
57
Concept neighborhoods
21
Bridge connections
76

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 37 topics
History · 19 topics
Overview · 10 topics
Pharmacology · 3 topics
Chemistry · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D02BB02 (WHO)
CAS Number
75921-69-6 N
ChEBI
CHEBI:136034
ChEMBL
ChEMBL441738 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Adverse effects

Pharmacology

Chemistry

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Afamelanotide connects Entity context

The extracted context around Afamelanotide shows recurring relationship patterns in the source. For example, Afamelanotide → Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, D-Phe7, It, MSH, NDP-MSH, NDP-α-MSH, Nle4 Another extracted example is Afamelanotide → Arizona, By, II, In, Later, MSH, University. Use these groups to spot repeated connection types before inspecting the individual relationships.

Afamelanotide

Top relations

related to Chemistry · 7
Afamelanotide → Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, D-Phe7, It, MSH, NDP-MSH, NDP-α-MSH, Nle4
related to history · 7
Afamelanotide → Arizona, By, II, In, Later, MSH, University
related to Pharmacology · 7
Afamelanotide → After, By, It, Its, MC1, MSH, This
Legal status · 4
Afamelanotide → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
has effect · 3
Afamelanotide → Other, The, Uncommon
related to Medical uses · 3
Afamelanotide → European Union, In, United States
KEGG · 2
Afamelanotide → as salt: D11334 N, D10511 N
is a · 2
Afamelanotide → international nonproprietary name, melanocortin 1 receptor
3D model (JSmol) · 1
Afamelanotide → Interactive image
AHFS/Drugs.com · 1
Afamelanotide → Monograph

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

trials effects erythropoietic protoporphyria skin drug us name light exposure phototoxicity adverse α-msh half-life peptide reactions clinical clinuvel sold medication

Afamelanotide relationships Subject–Predicate–Object triples

TTTA extracted 57 structured relationships around Afamelanotide. Examples in this analysis include Afamelanotide → 3D model (JSmol) → Interactive image and Afamelanotide → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Afamelanotide3D model (JSmol)Interactive image1.00infobox
AfamelanotideAHFS/Drugs.comMonograph1.00infobox
AfamelanotideATC codeD02BB02 (WHO)1.00infobox
AfamelanotideCAS Number75921-69-6 N1.00infobox
AfamelanotideChEBICHEBI:1360341.00infobox
AfamelanotideChEMBLChEMBL441738 Y1.00infobox
AfamelanotideChemSpider17310725 Y1.00infobox
AfamelanotideCompTox Dashboard (EPA)DTXSID402268431.00infobox
AfamelanotideDrugBankDB049311.00infobox
AfamelanotideElimination half-life30 minutes1.00infobox
AfamelanotideFormulaC78H111N21O191.00infobox
AfamelanotideIUPHAR/BPS13241.00infobox
AfamelanotideKEGGD10511 N1.00infobox
AfamelanotideKEGGas salt: D11334 N1.00infobox
AfamelanotideLegal statusAU: S4 (Prescription only)1.00infobox
AfamelanotideLegal statusUK: POM (Prescription only)1.00infobox
AfamelanotideLegal statusUS: ℞-only1.00infobox
AfamelanotideLegal statusEU: Rx-only1.00infobox
AfamelanotideLicense dataUS DailyMed: Afamelanotide1.00infobox
AfamelanotideMolar mass1646.874 g·mol−11.00infobox
AfamelanotideOther names[Nle4,D-Phe7]α-MSH; NDP-α-MSH; NDP-MSH; Melanotan; Melanotan-1; Melanotan I; EPT1647; CUV1647;1.00infobox
AfamelanotidePregnancy categoryAU: B11.00infobox
AfamelanotidePronunciation/ˌæfəmɛˈlænoʊtaɪd/ ⓘ1.00infobox
AfamelanotidePubChem CID161543961.00infobox
AfamelanotideRoutes of administrationSubcutaneous1.00infobox
AfamelanotideTrade namesScenesse1.00infobox
AfamelanotideUNIIQW68W3J66U1.00infobox
Afamelanotideis amelanocortin 1 receptor0.90text
Afamelanotideis ainternational nonproprietary name0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Afamelanotide bring nearby vocabulary together. In this analysis, examples include Exposure, Erythropoietic and Protoporphyria. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Afamelanotide
    • Exposure
    • Erythropoietic
    • Protoporphyria
    • Phototoxicity
    • Sun
    • Name
    • Α-msh
    • Us
    • Effects
    • Analogue
    • Scenesse
    • Synthetic
  • afamelanotide
    • Exposure
    • Erythropoietic
    • Protoporphyria
    • Phototoxicity
    • Sun
    • Name
    • Α-msh
    • Us
    • Effects
    • Analogue
    • Scenesse
    • Synthetic
  • food and drug administration
    • Us
    • Day
    • Drug
    • Clinuvel
    • Erythropoietic
    • Protoporphyria
    • Scenesse
    • Subcutaneous
    • Adults
    • European
    • Medication
    • Pain
  • adverse effects
    • Effects
    • Reported
    • Reactions
    • Trials
    • Clinical
    • Light
    • Scenesse
    • Subcutaneous
    • Us
    • Administration
    • Adults
    • European
  • erythropoietic protoporphyria
    • Protoporphyria
    • Phototoxicity
    • Exposure
    • Light
    • Scenesse
    • Administration
    • Adults
    • Medication
    • Pain
    • Sun
    • Name
    • Us
  • international nonproprietary name
    • Scenesse
    • Phototoxicity
    • Α-msh
    • Erythropoietic
    • Protoporphyria
    • Subcutaneous
    • Administration
    • Adults
    • European
    • First
    • Medication
    • Pain
  • phototoxicity
    • Scenesse
    • Adults
    • Erythropoietic
    • Protoporphyria
    • Exposure
    • Light
    • Subcutaneous
    • Administration
    • European
    • Pain
    • Sold
    • Sun
  • back pain
    • Sun
    • Exposure
    • Erythropoietic
    • Protoporphyria
    • Scenesse
    • Administration
    • Phototoxicity
    • Reported
    • Sold
    • Adverse
    • Clinical
    • Light

Connections between topic areas Semantic bridges

For Afamelanotide, one of the stronger structural bridges in this analysis connects Afamelanotide with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
AfamelanotideAdverse effects · splits 39 ⟂ 38
AfamelanotideHistory · splits 57 ⟂ 20
AfamelanotideOverview · splits 66 ⟂ 11
AfamelanotidePharmacology · splits 73 ⟂ 4
AfamelanotideChemistry · splits 74 ⟂ 3

Map overview Semantic statistics

Afamelanotide

Nodes77
Edges76
Triples57
Avg. degree1.97
Density0.025974
Components1

Source & methodology

TTTA analyzes the structure around Afamelanotide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Adverse effects & Pharmacology, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Afamelanotide · EN edition · Analysis: TopicsToTalkAbout

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