Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Protein domain

In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and folds independently from the rest. Each domain forms a compact, folded three-dimensional structure. Many proteins consist of several domains, and a domain may appear in a variety of different proteins. Molecular evolution uses domains as…

Regions & Measurement

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Protein domain. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Domain definition from structural co-ordinates

Cα-Cα distance mapHierarchical clusteringCα-Cα distancesDendrogramsWodak
49 related topics

Multidomain proteins

GAR synthetaseAIR synthetaseGAR transformylaseEGFKelch domains
19 related topics

Units of protein structure

Primary structureResiduesSecondary structureΑ-helicesΒ-sheets
14 related topics

Domains as evolutionary modules

ArchaeaBacteriaEukaryaSH2Immunoglobulin
9 related topics

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Background

Units of protein structure

Domains as evolutionary modules

Multidomain proteins

Domains are autonomous folding units

Domains and protein flexibility

Domain definition from structural co-ordinates

Domains of unknown function

Structural domain databases

Sequence domain databases

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Protein domain

Nodes130
Edges129
Triples105
Avg. degree1.98
Density0.015385
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Protein domain

Top relations

related to Example domains · 51
Protein domain → AG, Armadillo, AT, Basic, Ca2, Cadherin, Cadherins, Caspase, Death, DED, DED-DED, DNA, DNA-binding, Drosophila, EF, Examples, Foldon, GATA, Given, IgC1
related to Domains as evolutionary modules · 20
Protein domain → All, Alternatively, Archaea, Bacteria, Domain, Domains, Eukarya, Examples, For, Four, However, Many, Molecular, Nature, Often, Protein, Protein Data Bank, SH2, Structural, There
related to Domains of unknown function · 8
Protein domain → DUF, DUF1220, DUF2992, DUFs, Pfam, Surprisingly, There, These
related to Units of protein structure · 7
Protein domain → Folding, Generally, In, Since, The, There, This
see also · 6
Protein domain → Binding, Biology, CATH Protein Structure Classification, Classification, Proteins, SCOP
related to Domains and protein flexibility · 2
Protein domain → Protein, The
is a · 1
Protein domain → region of a protein's polypeptide chain that is self-stabilizing and folds independently from the rest

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

domains domain protein proteins structure structural structures folding two found residues many polypeptide one evolution used several different sequence units

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Protein domainis aregion of a protein's polypeptide chain that is self-stabilizing and folds independently from the rest0.90text
virus particles or muscle fibresinstance ofDomains can either serve as modules for building up large assemblies0.80text
or can provide specific catalytic or binding sites as found in enzymes or regulatory proteinsinstance ofDomains can either serve as modules for building up large assemblies0.80text
inversionsinstance ofgross rearrangements0.80text
translocationsinstance ofgross rearrangements0.80text
deletionsinstance ofgross rearrangements0.80text
duplicationsinstance ofgross rearrangements0.80text
arginineinstance ofThe DNA-binding region comprises a number of basic aminoacids0.80text
lysine.Cadherin repeatsinstance ofThe DNA-binding region comprises a number of basic aminoacids0.80text
SHCinstance ofPTB-containing proteins0.80text
IRS-1 are important for insulin responses of human cells.Pleckstrin homology domaininstance ofPTB-containing proteins0.80text
Protein domainrelated to Domains and protein flexibilityProtein0.60section

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.