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Double minute

Double minutes (DMs) are small fragments of extrachromosomal DNA, which have been observed in a large number of human tumors including breast, lung, ovary, colon, and most notably, neuroblastoma. They are a manifestation of gene amplification as a result of chromothripsis, during the development of tumors, which give the cells selective advantages for…

Overview, Formation & Role in cancer

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Formation

Role in gene amplification

Role in cancer

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Double minute

Nodes38
Edges37
Triples59
Avg. degree1.95
Density0.052632
Components1

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Double minute

Top relations

related to References · 58
Double minute → Ambros, Attardi, Barker PE, Baskin, Bibcode, BMC Molecular, Cancer Genetics, Carella, Cell Biology, Correlation, CT, Cytogenetics, D'Addabbo, Daniele, Dev, Double, February, Free, Gay, Gene

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Important terminology

dms amplification gene genes cell double cells dna chromosomes tumor minutes formation also doi pmid amplified cancer tumors oncogenes pmc

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
through the breakdown of a homogeneously staining regioninstance ofseveral studies suggest other processes for DM formation0.80text
Double minuterelated to ReferencesBaskin0.60section
Double minuterelated to ReferencesRosenberg0.60section
Double minuterelated to ReferencesRN0.60section
Double minuterelated to ReferencesDev0.60section
Double minuterelated to ReferencesJune0.60section
Double minuterelated to ReferencesCorrelation0.60section
Double minuterelated to ReferencesProc Natl Acad Sci0.60section
Double minuterelated to ReferencesUSA0.60section
Double minuterelated to ReferencesBibcode0.60section
Double minuterelated to ReferencesPMC0.60section
Double minuterelated to ReferencesPMID0.60section

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