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Double minute: Overview, Formation & Role in cancer

Double minutes (DMs) are small fragments of extrachromosomal DNA, which have been observed in a large number of human tumors including breast, lung, ovary, colon, and most notably, neuroblastoma. They are a manifestation of gene amplification as a result of chromothripsis, during the development of tumors, which give the cells selective advantages for…

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Double minute topic overview

The analysis highlights Overview, Formation and Role in cancer as prominent areas in the source structure around Double minute.

Related topics
33
Source areas
4
Connected nodes
37
Extracted relationships
59
Concept neighborhoods
20
Bridge connections
37

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 20 topics
Formation · 7 topics
Role in cancer · 4 topics
Role in gene amplification · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Formation

Role in gene amplification

Role in cancer

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Double minute connects Entity context

The extracted context around Double minute shows recurring relationship patterns in the source. For example, Double minute → Ambros, Attardi, Barker PE, Baskin, Bibcode, BMC Molecular, Cancer Genetics, Carella, Cell Biology, Correlation, CT, Cytogenetics, D'Addabbo, Daniele, Dev, Double, February, Free, Gay, Gene. Use these groups to spot repeated connection types before inspecting the individual relationships.

Double minute

Top relations

related to References · 58
Double minute → Ambros, Attardi, Barker PE, Baskin, Bibcode, BMC Molecular, Cancer Genetics, Carella, Cell Biology, Correlation, CT, Cytogenetics, D'Addabbo, Daniele, Dev, Double, February, Free, Gay, Gene

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dms amplification gene genes cell double cells dna chromosomes tumor minutes formation also doi pmid amplified cancer tumors oncogenes pmc

Double minute relationships Subject–Predicate–Object triples

TTTA extracted 59 structured relationships around Double minute. Examples in this analysis include through the breakdown of a homogeneously staining region → instance of → several studies suggest other processes for DM formation and Double minute → related to References → Baskin. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
through the breakdown of a homogeneously staining regioninstance ofseveral studies suggest other processes for DM formation0.80text
Double minuterelated to ReferencesBaskin0.60section
Double minuterelated to ReferencesRosenberg0.60section
Double minuterelated to ReferencesRN0.60section
Double minuterelated to ReferencesDev0.60section
Double minuterelated to ReferencesJune0.60section
Double minuterelated to ReferencesCorrelation0.60section
Double minuterelated to ReferencesProc Natl Acad Sci0.60section
Double minuterelated to ReferencesUSA0.60section
Double minuterelated to ReferencesBibcode0.60section
Double minuterelated to ReferencesPMC0.60section
Double minuterelated to ReferencesPMID0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Double minute bring nearby vocabulary together. In this analysis, examples include Minutes, Human and Tumors. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene amplification
    • Gene
    • Role
    • Dm
    • Formation
    • Growth
    • Event
    • Chromothripsis
    • Dms
    • Tumor
    • Tumors
    • Genes
    • Cancer
  • role in gene amplification
    • Gene
    • Role
    • Dm
    • Formation
    • Growth
    • Event
    • Tumor
    • Chromothripsis
    • Dms
    • Tumors
    • Genes
    • Cancer
  • Double minute
    • Minutes
    • Human
    • Tumors
    • Cells
    • Result
    • Extrachromosomal
    • Found
    • Fragments
    • Neuroblastoma
    • Resistance
    • Selective
    • Oncogenes
  • double minute
    • Minutes
    • Human
    • Tumors
    • Cells
    • Result
    • Extrachromosomal
    • Found
    • Fragments
    • Neuroblastoma
    • Resistance
    • Selective
    • Oncogenes
  • extrachromosomal dna
    • Extrachromosomal
    • Neuroblastoma
    • Circular
    • Fragments
    • Chromosomes
    • Ecdna
    • Resistance
    • Tumors
    • Human
    • Oncogenes
    • Minutes
    • Suggested
  • dna
    • Extrachromosomal
    • Circular
    • Fragments
    • Neuroblastoma
    • Chromosomes
    • Ecdna
    • Resistance
    • Tumors
    • Human
    • Oncogenes
    • Amplified
    • Chromosome
  • dna methylation
    • Extrachromosomal
    • Circular
    • Fragments
    • Neuroblastoma
    • Chromosomes
    • Ecdna
    • Resistance
    • Tumors
    • Human
    • Oncogenes
    • Amplified
    • Chromosome
  • role in cancer
    • Role
    • Tumor
    • Dms
    • Gene
    • Chromothripsis
    • Ecdna
    • Found
    • Fragments
    • Neuroblastoma
    • Resistance
    • Event
    • Human

Connections between topic areas Semantic bridges

For Double minute, one of the stronger structural bridges in this analysis connects Double minute with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Double minute — Overview · splits 17 ⟂ 21
Double minute — Formation · splits 30 ⟂ 8
Double minute — Role in cancer · splits 33 ⟂ 5
Double minute — Role in gene amplification · splits 35 ⟂ 3

Map overview Semantic statistics

Double minute

Nodes38
Edges37
Triples59
Avg. degree1.95
Density0.052632
Components1

Source & methodology

TTTA analyzes the structure around Double minute to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Formation & Role in cancer, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Double minute · EN edition · Analysis: TopicsToTalkAbout

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